Finding a Vaccine for Dengue Fever

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Introduction
Dengue fever is a tropical disease produced by a virus transmitted by a mosquito Aedes aegipti. This disease affects mainly tropical countries in Latin America, Africa and Asia and According to World Health Organization (WHO), dengue is a fast emerging pandemic-prone viral disease, and is one of four WHO future vaccine priorities. (WHO, 2013) Researchers in the United State, Brazil and Europe has been developing 4 vaccine candidates that are under clinical trials. These evaluations have been done in topical countries as Colombia, Brazil, Thailand and Singapore. Parallel to this race to develop a vaccine, has emerged a Dengue Vaccine Initiative (DVI) to speed the introduction of these vaccine in developing countries using the knowledge and expertise of researchers there. In all this process have been involve researchers, laboratories, Universities, companies and national health institutes, creating an intersection between regional systems of innovation (Medellin Ruta N), health clusters and a the technological systems of innovation for the vaccine technology, crossing geographical boundaries. Also nationals systems of innovation have an effect over the results that we are looking today. In this essay I pretend to describe how has been the intersection of 4 innovation systems; national, regional, sectorial and technological in the clinical evaluation of DENVax, one of the vaccines candidates developed by Invitrogen in the United States and evaluated in Colombia by the research group PECET in Medellin City.

Description of the Ecosystem and National capabilities to develop vaccines candidates.
Due the impact that this disease could have around the wold, it has been efforts to develop a tetravalent vaccine that creates ...

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...ical service.

Conclusions

Related variety uses the idea of cognitive distance to assess the extent to which knowledge can spillover or be transferred across sectors. It is argued that learning and knowledge transfer are facilitated when there is technological relatedness between sectors so cognitive distance is neither too great for learning to occur, or so close that novelty is hampered.(Asheim, Smith, & Oughton, 2011)

Third, there is a need to enhance our understanding of the dynamics of RIS and the emergence and evolution of new knowledge intensive industries, such as nanotechnology. In particular, to consider what factors shape the evolution and performance of knowledge intensive industries within RIS as they go through different phases of development, growth and consolidation (PORTER et al., 2005). Podría ser una de mis preguntas de investigación??????

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