Effectively Treating Fungal Problems with Terbinafine Hydrochloride

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Terbinafine Hydrochloride: Effectively Treating Fungal Problems

Abstract

Lamisil, which is chemically terbinafine hydrochloride, is the premier antifungal drug on the market. It effectively destroys fungal problems ranging from athlete’s foot to onychomycosis. However, Lamisil has a number of problems associated with it, including cost, side effects, and even effectiveness. Therefore, I created two analogs in an attempt to improve Lamisil, which I will discuss in my paper.

Plenty of fungal problems exist, including athlete’s foot, jock itch, ringworm, and onychomycosis (fungal infection beneath nails). However, many antifungal drugs exist as well, such as Lamisil, which is the most effective. Using the molecule terbinafine hydrochloride, it puts holes in the cell membranes of fungal cells, and can destroy fungi. Despite this, Lamisil has many problems such as harmful side effects, and a high cost, and can therefore be vastly improved. Some of Lamisil’s competitors, such as Tinactin, offer a similar medication for a cheaper price, and other analogs of the drug could prove to be safer and even more effective. For now though, Lamisil, the 87th best selling prescription drug in the world, is the best antifungal medication1.

Dermatophytes are parasitic fungi that infect the skin, causing athlete’s foot, ringworn, jock itch, and onychomycosis among other problems. These can result in dryness, itchiness, peeling skin, extreme discomfort, and discoloration of nails. Lamisil is a cure for all of these problems. Lamisil is made with the active ingredient terbinafine hydrochloride (C21H26ClN) 2:

3

Terbinafine hydrochloride is a white, crystalline powder that is sold as Lamisil in tablet, cream, and powder form. ...

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...rug/d04012a1>.

3"Terbinafine." DrugBank. 1 Feb. 2007. 23 July 2007

0508.txt>.

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5"Terbinafine." 2007. 23 July 2007 .

6"Tolnaftate." DrugBank. 1 Feb. 2007. 25 July 2007

1607.txt>.

7"Tinactin - Tough Relief." 2007. 27 July 2007

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8"Butenafine." DrugBank. 1 Feb. 2007. 25 July 2007

000833.txt.>

9"Lotrimin." 2007. 27 July 2007 .

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