Conclusion Work based on avian models suggested that the endothelium of the coronary artery originates from pro-epicardium (Perez-Pomares et al., 2002; Ishii et al., 2010) and sinus Venosus (Poelmann et al., 2003), and eventually grows into the aorta, thereby forming the coronary arterial orifices (Eralp et al., 2005). However, studies of coronary artery formation in mammals have not lead to similar conclusions. Recent work by Tian et al (2013b) revisited the question in mammals (using murine models) and provides strong evidence that it is more consistent with a coronary ingrowth model.
The Wu et al. (2012) study makes a valuable contribution to the ongoing debate on the origin and development of the coronary vascular bed. Indeed, coronary ECs arise from multiple sources, and the balance between these sources likely differs by anatomic region and species. Advances made in methods and experimental procedures are paving the road to a better interpretation of these embryonic events. High-resolution and real-time imaging to detect sprouting, budding, or EMT of endocardium will surely
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The global picture that emerges is one that illustrates cellular contributions from multiple sources. It may be that endocardial budding generates most intramyocardial coronaries, while angiogenic sprouting from the sinus venosus generates most subepicardial coronaries and a subset of intramyocardial coronaries. PE cells may contribute to a fraction of both EC populations, and give rise to most of the supporting smooth muscle cells, as well as contributions from preotic neural crest cells.. Evaluating and quantifying the contribution of each proposed cell source by anatomical location will be the next important step in furthering our understanding of coronary growth
Myocardial infarctions are caused by vascular endothelial disruption most often associated with plaque build-up or atherosclerosis that develops over several years and causes thrombus formation which in turn
Throughout the heart, Cardiac Muscle cells are connected together to form a large network from one end to the other. These cells form a shape such that each individual cell always remains in-contact with 3 others cells at all times.
Nitric oxide is a gaseous, diatomic molecule that plays an important role as a mediator of cardiac function, working largely as a vasodilator in the cardiovascular system. Nitric oxide is synthesized by a family of enzymes known as nitric oxide synthases (...
O’Rourke [13] describes the pulse wave shape as: “A sharp upstroke, straight rise to the first systolic peak, and near-exponential pressure decay in the late diastole.” Arteries are compliant structures, which buffer the pressure change resulting from the pumping action of the heart. The arteries function by expanding and absorbing energy during systole (contraction of the cardiac muscle) and release this energy by recoiling during diastole (relaxation of the cardiac muscle). This function produces a smooth pulse wave comprising a sharp rise and gradual decay of the wave as seen in Figure 5. As the arteries age, they become less compliant and do not buffer the pressure change to the full extent. This results in an increase in systolic pressure and a decrease in diastolic pressure.
Teupser D, Pavlides S, Tan M, Gutierrez-Ramos JC, Kolbeck R, & Breslow JL. (2004). Major reduction of atherosclerosis in fractalkine (CX3CL1)-deficient mice is at the brachiocephalic artery, not the aortic root. Proceedings of the National Academy of Sciences of the United States of America. 101, 17795-800.
Pulmonary arteries carry blood from the heart to the lungs where the blood picks up oxygen. The oxygen rich blood is then returned to the heart via the pulmonary veins. Systemic arteries deliver blood to the rest of the body. The aorta is the main systemic artery and the largest artery of the body. It originates from the heart and branches out into smaller arteries which supply blood to the head region brachiocephalic artery, the heart itself coronary arteries, and the lower regions of the body.
The walls of arteries are made up of three layers same as veins. Its inner endothelium is composed of epithelial cells which is very smooth. This layer helps minimise the friction. The tunica media provides strength and elasticity. It contains smooth muscles, collagen and large amount of elastic fibres.
...ape formation, movement of cardiac progenitor cells, heart tube, and heart function. A novel development of more specific assays, advance genetic screen efforts will provide new knowledge on cardiac development in the following years. Additionally, because of the zebrafish distinct features and its similarities to vertebrae, the zebrafish might become many researchers preferred model organism to study many mammal organs. Recently, the zebrafish has been used to study mechanisms that cause human cardiac and liver diseases and to model human hereditary and developed cardiac diseases. Due to the increase in sequencing efforts, the developing interest to study human liver and cardiac diseases. Also, the increase of resource and the more availability of the zebrafish model used in clinical and basic researchers involved in studying the liver, as well as cardiac diseases
The cells of a cardiac muscle are shaped and wider and shorted than a skeletal muscle however they are stripped like skeletal
The preliminary step in myocardial infarction is atherosclerosis. Atherosclerosis does not occur abruptly, it is a gradual and dynamic inflammatory disease which causes the narrowing of lumen due to the deposition of lipid and foam cells. The formation of fatty streak; which will eventually become a plaque causes the vessel lumen to diminish. The plaque will become unstable, rupture and eventually lead to the event of plaque disruption.
Coronary heart disease is defined by the hardening of the epicardial coronary arteries. The buildup of plaque in the arteries slowly narrows the coronary artery lumen. In order to better understand the physiology of the disease, it is important to first know the basic anatomy of the human heart. The aorta, located in the superior region of the heart, branches off into two main coronary blood vessels, otherwise known as arteries. The arteries are located on the left and right side of the heart and span its surface. They subsequently branch off into smaller arteries which supply oxygen-rich blood to the entire heart (Texas Heart Institute, 2013). Therefore, the narrowing of these arteries due to plaque buildup significantly impairs blood flow throughout the heart.
Coronary heart disease came in the public eye in the mid-20th century as a disease of pandemic magnitudes and it continues to be a major cause of death in the western world. The fundamental cause of coronary heart disease is Atherosclerosis. The term “atherosclerosis” is the combination of two Greek words which correctly imply the elements of the lesion. The first being “athero” the greek work for gruel which parallels to the necrotic core at the base plaque formation, and “sclerosis” from the Greek word hardening, corresponding to the fibrous cap on the outer layer of the plaque. (Vulnerable Atherosclerotic Plaque : Strategies for Diagnosis and Management, 1, 2)
One source of great mortality and morbidity in Europe and North America is the cardiovascular disease, Atherosclerosis. It is recognized as a chronic inflammatory disease of the intermediate and large arteries characterized by the thickening of the arterial wall and is the primary cause of coronary and cerebrovascular heart disease (Wilson, 2005). It accounts for 4.35 million deaths in Europe and 35% death in the UK each year. Mortality rate are generally higher in men than pre-menopausal woman. Past the menopause, a woman’s risk is similar to a man’s (George and Johnston, 2010). Clinical trials have confirmed that lipid accumulation, endothelial dysfunction, cell proliferation, inflammation matrix alteration and foam cell formation are characteristic features of the earliest pathogenesis of atherosclerotic disease, and that therapies targeted towards the treatment of those conditions are beneficial (Varghese et al 2005). This essay will summarise the development and factors predispose to atherogenesis, and discuss how the comprehension of cell and molecular based mechanism has led to novel therapies for atherosclerosis.
The human heart has four chambers, the right atrium, left atrium, left ventricle, and right ventricle. The human heart has a ton of amazing features. The normal heart rate for adults is 120/80. The human heart weighs twelve ounces and beats at seventy-two beats per minute it is the size of a human fist. Its blood flow has many functions and is extremely vital to our bodies. We would not be able to survive without our heart. I will talk about the functions of our heart and the blood flow of our heart. I will go in detail to let you know things you probably have never heard. Our heart, its four chambers, and blood flow are very interesting and vital to our well-being. Many things can ruin the process of the heart and the way that it works. I will talk about all of the ways that ruin it and I will cover the valves of the heart as well, which are important to the blood flow of the heart.