Comparing Meiosis I And Waardenburg Syndrome

In meiosis there are two stages appropriately named Meiosis I and Meiosis II. Each stage is split into four steps with the appropriate stage number subsequently following. The goal of meiosis is to have a final product of four haploid cells, cells that have one complete set of chromosomes but are not in a chromosomal pair. In Meiosis I, Prophase I is the starting step in which the parent cell’s chromosomes condense and the nuclear membrane begins to disintegrate. Additionally, two pairs of centrioles are created and move to opposite sides. Crossing over occurs in this step as well. Crossing over is the act of homologous chromosomes trading parts of their chromosomes. This process is to allow genetic diversity within offspring and occurs randomly. The replicated chromosomes in this stage are called tetrads, which are cells with two chromosomes and consequently four sister chromatids. Sister chromatids are two chromatids which, together, make up a chromosome. Following Prophase I is Metaphase I, in which the

This syndrome is inherited dominantly, thus there are families with multiple generations who have inherited one or more of these features. They exhibit pigment discrepancies such as alarmingly clear or light eyes, discolored eyes, white patches of hair, lack of pigment in the skin, and on non-physically visible note some degree of cochlear deafness. The disease was named after Petrus Johannes Waardenburg who first noted the correlation between those who had two different colored eyes and hearing problems. The breakthrough of which gene was effected was made when noticing mice with splotched coating are affected in the same gene that could cause Waardenburg Syndrome in humans. This gene is located in humans to chromosome 2, Pax3. Often it is because this gene is altered or deleted. It is unknown in which meiotic stage this first occurred, or if meiosis has effected the cause of this at