Brain Capillary Physiology

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other organs, the parenchymal flow in the brain is controlled entirely outside of the organ. Two-thirds of the vascular resistance in the brain is due to large cerebral arteries and pial vessels [4]; non-pial vessels are responsible for the remaining one-third of vas- cular resistance [4].
Furthermore, the brain capillary system is highly heterogeneous. The brain uses an additional mechanism, hyperaemia, to increase the flow of blood to the regions in which neurons are active. According to this mechanism, neurons and astrocytes dir- ectly regulate the local blood flow within the capillaries, resulting in local neurovascular coupling. Initially, it was proposed that the local increase in blood flow upon neuronal activation was caused by a metabolic

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