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Biological influences of cocaine
Essays on the physical effects of cocaine
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Recommended: Biological influences of cocaine
Marisol Muneton
Professor Muller
BIOS 104
TA: Monica Farfan
The Biology of Cocaine Addiction Drugs are addictive substances that produce pleasant states such as euphoria or relieve distress. Drugs are classified into categories which include: depressants, stimulants, and hallucinogens. Depending on the type of drug and the way it is used, referring to if it is sniffed, swallowed, injected, or smoked depends the effect the addiction of that drug has on the body. Scientists such as Koob and Le Moal argue that drug addiction is caused by the dysregulation of the reward mechanism and subsequent allostasis which is the ability to achieve stability through change (Cami and Farre, 2003). Drug addiction produces adaptive changes in the central nervous
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According to Gawin (1991), cocaine addicts report that during binges everything including: nourishment, sleep, money, family, responsibilities, and survival, are all focused on cocaine. After long-term cocaine use, cocaine addicts can develop digestive disorders, weight loss, physical deterioration, deterioration of the nervous system, increase heart rate and blood pressure which can lead to heart attack and stroke (The Columbia Encyclopedia, 2013). Cocaine produces its effect of euphoria when an accumulation of dopamine is form in the synapse (NIDA, …show more content…
Cocaine addiction causes various changes to develop in the body of an addict especially most resulting in the brain. One of the effects of cocaine is that it blocks pain sensation and it stimulates the central nervous system causing changes in cell signaling and brain circuitry to develop. Some of the changes cocaine addiction causes in the brain is cognitive impairments which result in deficits in decision-making, abstract reasoning, and nonverbal problem solving. Cocaine also causes affective dysfunctions such as depressive disorders and attention deficit disorder. Other problems cocaine addicts can develop due to their cocaine addiction is digestive disorders, weight loss, and physical deterioration. The use of cocaine accelerates the heart rate and increases blood pressure which can led to an addict suffering a heart attack or stroke which can become
Cocaine is a classified ‘Schedule II’ drug, also known as “crack”, and “coke” it is a powerful drug, and addictive stimulant well known as a psychoactive substance. That comes from a plant called coca leaf that has been around since the mid-1800s and throughout the 20th century. “In the mid-1980s, addiction to the drug was seen as exaggerated or dismissed as psychological and not addiction” (Miller, Gold, Smith, 1997, p.62). In the past, cocaine’s original use was for medical purposes as local anesthetic for surgeries. Now its usage is illegal and this drug is immersed into the body through various ways. However,...
“It is synthesized from the leaves of the coca plant to form a paste. This paste is further synthesized and cut with adulterant substances to make it into street-level cocaine that can be injected, snorted or smoked. To make the paste, there is a process of extracting the cocaine that includes the use of toxic chemicals. There are two main ways that the cocaine paste is made: solvent extraction and acid extraction”.
There are three different stages to addiction, the first being the adaptive stage. In this stage, the user is on top of his/her game. They feel as if they can function better while on the drug and are able to handle larger amounts. This is the person that can smoke crack before they go to work and will probably be more productive then most. “Cocaine is a powerfully addictive drug. Once having tried cocaine, an individual may have difficulty predicting or controlling the extent to which he or she will continu...
David, A.G (2013). Cocaine use disorder in adults: Epidemiology, pharmacology, clinical manifestations, medical consequences, and diagnosis. ©2014 UpToDate, Inc.
Koob, G. F. (2011, Winter -). Neurobiology of Addiction. Retrieved from Focus: The Journal of Lifelong Learning in Psychiatry: http://focus.psychiatryonline.org/data/Journals/FOCUS/4266/foc00111000055.pdf
Cocaine (C17H21NO4) comes from the leaf of an Erythroxylon coca bush. It is a drug that effects the central nervous system. It causes feelings of euphoria, pleasure, increased energy and alertness. People under the influence of cocaine often do not feel the need for food or sleep. They also feel energetic and may talk a lot. However, depending on factors such as environment, dosage, and the manner in which the drug is taken, cocaine can have adverse effects such as violent, erratic behavior, dizziness, paranoia, insomnia, convulsions, and heart failure to name a few. Long- term effects of cocaine include, but are not limited to strokes, heart attacks, seizures, loss of memory, and decrease in learning capability (1).
...a prolonged period of time. This sensation is followed by increase heart rate, blood pressure, and sexual appetite. Dopamine uptake continues to be blocked by constant use of cocaine as the system releases less and less dopamine and the reward system goes dry. The cocaine user becomes anxious and unable to experience pleasure without the drug. Consequently, the postsynaptic cells become hypersensitive and sprout new receptors in a desperate effort to pick up dopamine signals. A vicious cycle of addiction begins and cocaine is needed to experience pleasure as it suppresses dopamine release even more. Dopamine alone is not enough to maintain addiction, glutamate, which plays an important role in learning, is required to maintain addiction. Glutamate signaling seems to cause more permanent changes in the brain that leads to the drug-seeking behaviors elicited by users.
A study done by Puig and colleagues (2012) compared the effects of intermittent (once daily) and binge (three times a day) cocaine treatment for 1 and 14 days after the last cocaine injection on spontaneous locomotor activity and dopamine levels in the NAc in rats. The intermittent treatment led to a spontaneous increase in dopamine and in locomotor activity at the exact hour which rats were habituated to receive a cocaine injection (Puig, Noble & Benturquia, 2012). The binge treatment led to sensitization of locomotor effects of cocaine, associated to a dopamine release sensitization in the NAc (Puig, Noble & Benturquia, 2012). These results show the addictive nature of cocaine and the behavioural and sensitization effects it has on the animal, which can be related to the effects it can possibly have on humans (Puig, Noble & Benturquia,
The most commonly abused substances are Nicotine, Inhalants, Alcohol, Cocaine, Amphetamines, Prescription medications, Heroin, Ecstasy and Marijuana. 1a(National Institute on Drug Abuse, 2011) Initially, a person may find themselves using substances voluntarily and with confidence that they will be able to dictate their personal use. However, over the period of time that drug use is repeated, changes are taking place throughout the brain, whether it is functionally or structurally. Drugs contain chemicals that enter the communication system of the brain and disturb the way in which nerve cells would typically send, receive, and process information. The chemicals within these drugs will cause a disruption to the communication system by either imitating the brain’s natural chemical messengers or by over-stimulating the brains “reward system” by sending mass amounts of dopamine. As an individual prolongs his or her use of these substances, they may develop an addiction.
The use of cocaine in the United States has declined over the last twenty years while the use of crack has increased. Many people avoided the use of crack because of the harmful chemicals used in creating the drug. One of the reasons why crack became popular is because of not needing to inject the drug hence less risks of being infected by the AIDS virus. Carroll (2000) states cocaine is the most powerful stimulant of natural origin. Most users snort or inject the drug to enable a quicker “high.” Cocaine use brings on many health problems. Fatal complications occur from regular use, for example, liver damage, seizures, elevated blood pressure causing stroke, heart failure, or heart attack.
There are many biological factors that are involved with the addicted brain. "The addicted brain is distinctly different from the nonaddicted brain, as manifested by changes in brain metabolic activity, receptor availability, gene expression, and responsiveness to environmental cues." (2) In the brain, there are many changes that take place when drugs enter a person's blood stream. The pathway in the brain that the drugs take is first to the ventral tegmentum to the nucleus accumbens, and the drugs also go to the limbic system and the orbitofrontal cortex, which is called the mesolimbic reward system. The activation of this reward system seems to be the common element in what hooks drug users on drugs (2).
The world involving drug addiction is a taboo topic to many. However, drug addiction is a very real topic that occurs worldwide. The widespread use of drugs is not restricted to the United States, with roughly five percent of the world’s population using in the past few months (Mosher & Akins, 2014). Many scientists, doctors, and specialists study addiction and try to find an explanation for why so many become addicted.
Humans are environmentally and genetically predisposed to developing a motivated addictive behavior. Addiction is a brain disease and a behavior. All behaviors are choices. Choices that adolescences make at a young age directly affect the outcomes of their futures. Many factors contribute to an adolescence becoming an addict or exhibiting a drug seeking behavior. Nearly all drugs of abuse increase dopamine release. Dopamine is an important neurotransmitter in drug abuse and addiction. Dopamine plays a role in reward motivated behaviors, motor control and important hormones. It’s known as the “feel good hormone” which is why people abuse drugs that increase the release of dopamine. Since life is unpredictable, our brains have evolved the ability to remodel themselves in response to our experiences. The more we practice an activity the more neurons developed in order to fine-tune that activity causing addictive behaviors to be detrimental.
Abuse can cause countless medical problems to the body. A person who is addicted will continue to stimulate themselves regardless if they are aware of the negative chain reactions. Once addicted, it becomes difficult to stop due to how the body has become dependent. Health will be harmed the more a stimulant is used. Health effects include: cardiovascular disease, strokes, cancer, HIV/AIDS, hepatitis, lung disease, mental disease, birth defects. Mental health is what keeps a person in the right mind to make better decisions and have better control in life. Drugs have the ability to change mood and behavior. If drugs have affected the brain already, the desire increases which changes mental health. Some may not realize that they have been affected their health negatively. “A person who abuses drugs may not realize they have a problem until pronounced effects of drug abuse are seen, often physically. While drug abuse effects on the body vary depending on the drug used, all drug abuse negatively impacts one 's health (Addictions Community). Since drugs create many health issues, treatment is not a simple task. Treatments are hard to obtain and addictions often go
Addictive substances cause an increase a neurotransmitter called dopamine, which goes to a part of the brain called the nucleus accumbens and produces pleasurable sensations/responces. This pathway is called the reward pathway. Naturally dopamine release does not occur often, so when one repeatedly uses drugs that cause dopamine release receptor cells become overwhelmed and shut down. The brains ability to produce dopamine by itself decreases, but the need for it remains, creating a dependency on the substance. Addictive substances are classified into two catagories, stimulis and depressants. Stimulants such as cocaine stimulate the cntral nervouse system while depressants such as heroine depress the central nervous system. Cocaine is a powdery white substance that can be inhaled or injected, as listed above it is a stimulant that effects the central nervous system. Cocaine increases the levels of the dopamine in the brain. Normally dopamine is released and then recycled back into the cell that released it, therefore shutting down the signal of pleasure between neurons. Cocaine prevents the dopamine from getting recycled and causes a build up of it in the synapse, or space between neurons. This enhances the dopamine signal and therefore causes a flood of dopamine, which causes cocaine’s jittery energetic ‘high’. Cocaine is addictive due to the rush of dopamine and the cells inability to produces dopamine