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Essays on CRISPR technology
Essays on CRISPR technology
Essays on CRISPR technology
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CRISPR is a natural occurring process whose purpose is to act as a defense mechanism fighting off viruses in prokaryotic organisms. Scientist, however, have figured out a way to emulate this same process. First by creating a piece of RNA who matches part of a desired gene which they intend destroy, then the RNA is bonded to a Cas9 and sent through the nucleus, next the RNA is binded to the DNA to where it signals Cas9 to the strands, and finally the cell miserably fails to correct the cut, but along the way it accidentally adds a few nucleotides which shuts the gene down. Cas9 plays a vital role in this process since Its a protein in charge of locating and severing target DNA. The protein is split into six domains and the largest one is responsible …show more content…
7). Korean, Chinese and American scientist experimented with embryo’s who were infected with a heart defect and with the use of CRISPR they noticed after a few days 72% of the embryos were corrected. For a patient this could simply mean hope and promise for the future of their life since as of now there is no technology with the same capabilities as this one. With a bit more time and research CRISPR could be a necessary asset to these particular …show more content…
The largest controversy over DNA enhancement is the potential to create designer babies. A designer baby is self explanatory; its a baby whose genetic makeup is hand selected to ensure a specific gene is present. The process can be used for germline editing which permanently changes the genetic makeup of an embryo. The controversy comes into play when germline editing is discussed because basically the history of an unborn child is in the hands of a scientist whose intentions may not coincide with yours. A survey conducted around 2016 indicated the fact that highly religious individuals weren't to fond of
In the book, Crispin: The Cross of Lead, the protagonist Crispin faces many conflicts throughout the book in which he must conquer in order to find who he really is. These conflicts change Crispin as a character over the course of the book, as he overcomes them to find out his true self. One conflict for Crispin is person vs society where he becomes known as a wolf’s head and does not have any friends, or family. This is until he meets Bear who helps Crispin overcome this conflict. For example, John Aycliffe tries to find Crispin, but helps him get away. As the story develops Crispin saves Bear from John Aycliffe, showing their friendship.
It helps medics to find a direct genetic cause of the patient’s condition and target it with pharmaceutical or other therapies. The technology is used for the identification of DNA sequences that increase risks of current diseases and disorders; with this information carriers can start to make efforts to prevent them before the development of the problem. The video mentioned 200 actionable genes, structures that have direct links with a specific condition. Knowing about their presence, people have a chance to bring in preventive measures like taking anticoagulants in the case of identification of a thrombogenic gene. The technology led to the significant improvement of diagnostics and personalized treatments. It helped to find a rare, life-threatening mutation in case of Beery twins and assign a drug to a girl (Alexis) that returned her to a normal life. In the case of cancer genome sequencing led to the development of genetic drags, which target essential tumor genes and make malign structures to shrink. The video mentioned a product that works with the BRАF protein that induces cells to uncontrolled division; the drug led to the remission in the patient with metastasizing melanoma. Such treatment was effective in the case of cystic fibrosis. In the case of the breast cancer the technology helps to evaluate the aggressiveness of the condition and make a personalized decision about chemotherapy. The video also mentioned the pre-implantation genetic diagnosis – an early-staged technology that prevents the development of inherited disorders in
What do one think of when they hear the words “Designer Babies”? A couple designing their own baby of course, and it’s become just that. Technology has made it possible for there to be a way for doctors to modify a babies characteristics and its health. Genetically altering human embryos is morally wrong, and can cause a disservice to the parents and the child its effecting.
Picture a young couple in a waiting room looking through a catalogue together. This catalogue is a little different from what you might expect. In this catalogue, specific traits for babies are being sold to couples to help them create the "perfect baby." This may seem like a bizarre scenario, but it may not be too far off in the future. Designing babies using genetic enhancement is an issue that is gaining more and more attention in the news. This controversial issue, once thought to be only possible in the realm of science-fiction, is causing people to discuss the moral issues surrounding genetic enhancement and germ line engineering. Though genetic research can prove beneficial to learning how to prevent hereditary diseases, the genetic enhancement of human embryos is unethical when used to create "designer babies" with enhanced appearance, athletic ability, and intelligence.
Over 40 years ago, two men by the names of James Watson and Francis Crick discovered deoxyribonucleic acid, or DNA. DNA is hereditary material in humans and almost all other organisms (What is DNA?). From this finding, gene therapy evolved. Today, researchers are able to isolate certain specific genes, repair them, and use them to help cure diseases such as cystic fibrosis and hemophilia. However, as great as this sounds, there are numerous ethical and scientific issues that will arise because of religion and safety.
Gene therapy is a technique which has developed in the wake of recombinant DNA (rDNA) technology. It is a process which results in the correction of a genetic disorder by the addition of a piece or fragment of DNA into the genetic material of a living, functioning cell. A mere thirty years ago this concept belonged to the realm of the human imagination made manifest in the works of science fiction. Today it belongs to the realm of the human imagination made manifest in the works of science, period. It is mind boggling to try to comprehend the far reaching effects of gene therapy. How is it affecting society? Who will benefit from its use? Should it be used at all? Should research continue? How do we answer all of these questions? The answers are not readily available, nor are they black and white, but an attempt at finding some solutions must be made. Before exploring this line of thought further, a basic understanding of the technical aspects of gene therapy is essential.
In September 14, 1990, an operation, which is called gene therapy, was performed successfully at the National Institutes of Health in the United States. The operation was only a temporary success because many problems have emerged since then. Gene therapy is a remedy that introduces genes to target cells and replaces defective genes in order to cure the diseases which cannot be cured by traditional medicines. Although gene therapy gives someone who is born with a genetic disease or who suffers cancer a permanent chance of being cured, it is high-risk and sometimes unethical because the failure rate is extremely high and issues like how “good” and “bad” uses of gene therapy can be distinguished still haven’t been answered satisfactorily.
"What's the worst that can happen to me? I die, and it's for the babies," said Jessie Gelsinger as he left for the hospital to receive gene therapy treatment. (Stolberg) People risk their lives everyday in the name of science. One such science that people have recently been drawn to is gene therapy. Although, gene therapy may be new and exciting and it may be helping to find cures to diseases we only dreamed of curing, we have to remember it is dangerous. It needs to be done with much supervision. Every new step we take in the advancement of gene therapy should be thought over because the consequences could reach farther then we ever believed they could. There are so many dangers of the techniques used that can lead to consequences as serious as death. The government imposes many guidelines, and it needs to stay that way. The biggest dangers, however, may be in what is to come.
Genetic Engineering has recently become a contentious topic within medical and social circles. Controversial topics such as Sex Selection and Designer Babies are linked to Genetic engineering. They are destructive in every circumstance. Genetic Engineering is detrimental towards the individual and all posterity.
Genes are, basically, the blueprints of our body which are passed down from generation to generation. Through the exploration of these inherited materials, scientists have ventured into the recent, and rather controversial, field of genetic engineering. It is described as the "artificial modification of the genetic code of a living organism", and involves the "manipulation and alteration of inborn characteristics" by humans (Lanza). Like many other issues, genetic engineering has sparked a heated debate. Some people believe that it has the potential to become the new "miracle tool" of medicine. To others, this new technology borders on the realm of immorality, and is an omen of the danger to come, and are firmly convinced that this human intervention into nature is unethical, and will bring about the destruction of mankind (Lanza).
As the rate of advancements in technology and science continue to grow, ideas that were once viewed as science fiction are now becoming reality. As we collectively advance as a society, ethical dilemmas arise pertaining to scientific advancement, specifically concerning the controversial topic of genetic engineering in humans. Human genetic engineering increasingly causes dissonance between various groups of scientific and religious groups of people in regards to if we should or should not ‘play god’ and attempt to modify humans for the better of the race. First, let’s take a look at what exactly genetic engineering is; according to, yourgenome.org, “Genetic engineering refers to the direct manipulation of DNA to alter an organism’s
Human genetic engineering can provide humanity with the capability to construct “designer babies” as well as cure multiple hereditary diseases. This can be accomplished by changing a human’s genotype to produce a desired phenotype. The outcome could cure both birth defects and hereditary diseases such as cancer and AIDS. Human genetic engineering can also allow mankind to permanently remove a mutated gene through embryo screening as well as allow parents to choose the desired traits for their children. Negative outcomes of this technology may include the transmission of harmful diseases and the production of genetic mutations. The benefits of human genetic engineering outweigh the risks by providing mankind with cures to multiple deadly diseases.
...nd being able to pick a child and their specific gene should not be allowed. Those who would have their children engineered for cosmetic purposes should not be allowed to do so. There needs to be more public discussion of the issues. Many express unease about genetically redesigning our children by saying that we should not play God. These concerns may have more to do with the ‘playing’ than with the ‘God’ part. Should we be manipulating human biology and society like this? Technically and socially, do we know what we would be doing? The possibilities of physical changes are endless, as are the reprecussions.
In a recent study by Editas Medicine, they are working with CRISPR to prevent a blinding disorder called “leber congenital amarurosis” which is a rare inherited disease (Knapton, 2015). This disorder is due to a defect in a gene that encodes for a protein that is essential for vision, using CRISPR they are able to cut out the mutated areas. This is one example on how modifying DNA can be beneficial and why it should be accepted. Many inherited disorders like cystic fibrosis or Tay-Sachs. With parents having genetic screen tests they can provide a better future for their children and prevent them from a life with a
The moral conflicts put aside, the process of genetic engineering is difficult. Changing the proteins in people’s body differently is an unnatural action. Scientists state that genetic engineering only works 50% of the time. Also, when a new gene is placed in the gene code, there will be various mutations that will definitely result in change but may not be for the better.