Antiplatelet Essay

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1.1 DRUG INTRODUCTION

Antiplatelet drug are used to treat heart disease. They are powerful medications that prevent the formation of blood clots. When you are wounded, platelets arrive on the scene and group together, forming a blood clot that stops the bleeding. When an injury involves a break in your skin, this is a good thing. But platelets can also aggregate when injury to a blood vessel occurs from within the inside, as may happen in an artery affected by atherosclerosis. In this situation, the platelets cause blood clots to develop in an already injured artery. Antiplatelet medications can prevent this process from happening.

Antiplatelet may be prescribed for patients with a history of:
- Coronary artery disease
- Heart attack
- Angina (chest pain)
- Stroke and transient ischemic attacks (TIAs)
- Peripheral artery disease …show more content…

o Antithrombotic derives from reduction in thromboxane A2. o Aspirin also has analgesic, anti inflammatory and antioxidant properties. Some of the beneficial actions of aspirin in patients with cardiovascular disease (CVD) may be related to these as well as its antithrombotic effect. However, some of these effects are only apparent at much higher doses.
CLOPIDOGREL
An ADP receptor antagonist that competitively inhibits ADP from binding to platelet receptor, preventing ADP-mediated up regulation of glycoprotein (GP) IIb/IIa receptor, again blocking amplification of platelet aggregation. o Direct comparison of Clopidogrel may indicate that it is a slightly more effective Antiplatelet drug than aspirin. o More importantly, Clopidogrel is routinely used In the treatment of acute coronary syndrome (ACS) and post percutaneous coronary intervention (PCI) stenting in conjunction with aspirin.
PRASUGREL

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