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Iron deficiency anemia
Proposal about anemia
Pathophysiology of iron deficiency anemia
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Recommended: Iron deficiency anemia
Anemia is a global concern that impacts all individuals and nearly half of the anemic cases are caused from iron deficiency. Iron deficiency anemia is most prevalent in children, pregnant, and nonpregnant women. Iron deficiency is caused from inadequate iron intake and absorption, increase iron requirements for growth, or from excessive iron loss (Pasricha, Drakesmith, Black, Hipgrave, & Biggs, 2013). Iron plays a crucial role in hemoglobin synthesis. With low iron, red blood cells have reduced oxygen-carrying capacity causing anemia. Symptoms include fatigue, weakness, pallor, and shortness of breath (Burchum & Rosenthal, 2016). If left untreated, there is a risk for organ damage, or ischemia, due to worsening anemia. Treatment must be focused on restoring iron to the body and replenish iron stores (Schrier & Auerbach, 2018). Children need iron for brain development to improve cognitive, psychomotor, and physical development. Long term iron deficiency in children can cause irreversible damage (Pasricha et al., 2013).
Iron can be obtained from food in heme form, which is easier to absorb, from meat, poultry, and fish;
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Assessing the age of mothers and the number of children would also provide insight to the prevalence of iron deficiency anemia. Multiple births, closely together, and prolonged lactation will deplete the stores of iron for that woman (Anand et al., 2014). These iron depletions can impact the iron stores on their children. One method of providing iron to the child is delayed cord clamping at birth. Allowing one to three minutes after delivery to clamp the cord will allow for a placental transfusion. Allowing this transfusion increases the infants iron stores which will also improve fine motor and social development. This does not go without a risk to the child. Delaying the clamping of the cord can increase the risk of neonatal hyperbilirubinemia (Pasricha & Drakesmith,
Vitamin B12 is an essential water soluble vitamin that must be carefully regulated to prevent deficiency related complications in the nervous, gastrointestinal, and cardiovascular systems (e). This review begins with a discussion of B12 absorption and role as a cofactor for L-methylmalonyl-CoA mutase and methionine synthase (e). Laboratory findings are interpreted along with associated disease conditions. Finally, assay methods are discussed including blood smear and complete blood count, B12 competitive-binding immunoenzymatic assay, homocysteine tandem mass spectrometry, methylmalonic acid liquid chromatography tandem mass spectrometry, and the Schilling test.
a) Urinalysis with significantly increased amounts of blood (via dipstick and sediment), protein, and leukocytes as well as slightly increased bilirubin and slightly decreased pH;
Chaparro CM, Neufeld LM, Tena Alavez G, Eguia-Liz Cedillo R, Dewey KG. Effect of timing of umbilical cord clamping on iron status in Mexican infants: a randomized controlled trial. Lancet 2012;367:1997–2004. Retrieved November 9, 2014
Vitamin B12 deficiency limits selenium methylation and excretion resulting in higher tissue selenium levels and subsequent toxicity. It occurs in people whose digestive systems do not adequately absorb the vitamin from the foods they eat. Vegetarians who eat eggs and milk products are the most at risk because, on average, they consume less than half the adult vitamin B12 Recommended Dietary Allowance (RDA) while strict vegans (who don't eat any animal products, including meat, eggs, or milk) are at an even greater risk. Vitamin B12 is important since it works with the vitamin folate to make the body’s genetic material and help keep levels of the amino acid homocysteine in check which helps to decrease heart disease risk. It is also essential in the production of red blood cells which carry oxygen through the blood to the body’s tissues. Life Extension gives offers some of selenium supplements. Babies who are born of parents with low selenium and vitamin B12 rich foods are at risk of anaemia.
The patient, LL, is a twenty four year old female who was diagnosed with obsessive-compulsive disorder five years ago. Around the ago of eighteen, LL started to experience many symptoms of obsessive-compulsive disorder. She had just started her freshman year at a local college and moved into the dorms with a random roommate. LL was constantly washing her hands and grossed out by the germs, so she came to realize she had a phobia of germs. She would begin sweating and having major anxiety when people went to shake her hand or her roommate would touch her food or any of her things. LL started skipping class and isolating herself in her room in order to avoid contact with other people. When her grades dramatically declined,
Kidney dialysis comes at a price. With chronic kidney disease (CKD), there can be problems with iron depletion. Dialysis slowly depletes a patient of iron. On average, about 5-7 mg of iron is lost in each session. Until recently, the main way doctors tried to compensate for this loss was by adding 100 mg of iron into the bloodstream. This treatment comes with risks of oxidative stress and can cause liver damage. A new drug has recently been in the news and seems to help greatly with this problem. The drug is called Triferic. Triferic mimics the way iron is absorbed into the body naturally. The absorption gradually goes to the body’s bone marrow and helps to maintain levels of hemoglobin. Triferic is still in the trial stages with 3 successful trials done so far. It very well may become an integrated treatment for those with CKD. (Glatter, 2013)
Yearly, around six hundred to nine hundred people are diagnosed with Aplastic Anemia within the United States. Aplastic Anemia is a autoimmune hematological disorder that causes pancytopenia which is a reduction in major blood components, namely, erythrocytes, leukocytes and platelets. This disease has been labelled as a type of bone marrow failure, that is often due to not one but a variety of disorders that occur simultaneously. Aplastic Anemia can therefore be defined as a bone marrow disorder that is often rare, non contagious, and can often be life threatening.
There are many causes of anemia in the body. Some factors include genetics and deficiencies in the diet. Ms. A claims that for the past 10 – 12 years menorrhagia and dysmenorrheal have been a problem for her. Menorrhagia is abnormal and heavy menstrual bleeding during menstruation (Mayoclinic, 2013). Menorrhagia can deplete iron levels in the blood and increase the risk of an individual to have iron deficiency anemia. This is the cause of Ms. A’s anemia. Moreover, Ms. A says that she constantly takes aspirin especially in the summer to prevent stiffness in the joints. Aspirin affects and hinders the production of red blood cells (Mayoclinic, 2013). From the description of anemia given above, the lack of red blood cells, leads to low levels of iron and therefore low levels of hemoglobin which in turn affects the transportation of oxygen and thereby causing shortness of breath. Ms. A’s initial complains of shortness of breath and fatigue is the reason why she went to see the physician.
Dialysis is a process by which excess waste and water is removed from the blood to maintain a balanced proportion of contents/nutrients. Dialysis is done by using different dialysis machines which are usually very costly and sensitive. The duty to maintain a constant proportion of contents in the blood is usually done by kidneys but when they are not functioning properly the procedure of dialysis used. Therefore it is a very important and beneficial process for people whose kidneys are not functioning properly or who cannot undergo a kidney transplant due to various reasons for example blood type or reactive immune system. The process of dialysis might look very simple but there is a lot more ethical complexity related to it that will be elaborated. (White & Fitzpatrick)
Iron is an essential part of a healthy diet. Iron compounds are employed for medicinal purposes in the treatment of anemia, when the amount of hemoglobin or the number of red blood corpuscles in the blood is lowered.
Vitamin B12 is an essential nutrient that plays an important role in DNA synthesis and nerve function. It is contained in high amounts in animal derived foods such as milk, eggs, and meat. The vitamin is stored in the liver long-term. Individuals with vegetarian, vegan, or other forms of restricted diet may develop the condition after approximately 6 months as liver stores of vitamin B12 become depleted. Some individuals develop the condition due to autoimmune destruction of cells in the stomach that produce intrinsic factor. Intrinsic factor is necessary for proper absorption of vitamin B12 in the small intestine.
Sickle cell anemia affects millions of people around the world, with about 70,000 Americans inheriting the disease, and many others carrying the sickle cell trait (Genetics). This disease mostly affects people that have African and Mediterranean roots, mostly because this disease provides protection for people from malaria which kills 3,000 African children daily (Malaria). Malaria is a deadly infectious disease that is transmitted by to humans when mosquitoes sting them (Learn). Sickle cell anemia is the most common blood disorder that is a result of a mutation in the genes causing a mutated form of hemoglobin, the protein that helps red blood cells transport oxygen to the body from the lungs. The mutated form of hemoglobin, hemoglobin S, causes the red blood cells to alter their shape into a fragile crescent or sickle shape, which is the main cause for any negative effects a person with sickle cell anemia might have.
...ver problems. It may also make the person more likely to get infections. Blood transfusions may help control some symptoms. But this could lead to having too much iron, as it stated before. Too much iron could damage the heart, liver, and endocrine system.
Health, nutrition and fitness are the three interrelated areas that determine an individual's sense of happiness and well being.
There are numerous public health problems that can be addressed in my Southside of Chicago community. Among the several public health problems facing my Southside of Chicago community there are two that are more urgent. Health education or one might say lack thereof is a problem that needs to be addressed. My community is plagued with many of the residents suffering from high blood pressure, diabetes, and the killer virus known as HIV. In most cases these conditions can be prevented with healthier lifestyles and access to nutritious organic foods. In addition, environmental health is another urgent problem my community is facing. Access to clean, safe water and air is supposed to be a fundamental human right aimed at a healthy environment. Yet, my community consists a waste contaminated beach, numerous deteriorated building that are still occupied, and a countless number of restaurant and stores supplying our residents with services that are endangering their health.