Liquid Paraffin Essay

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3.2.7 Liquid Paraffin It is a transparent, colorless, viscous, oily liquid. It is tasteless and odorless when cold and have a faint odor of petroleum when heated. It is practically insoluble in 95% ethyl alcohol, glycerin and water. It is soluble in benzene, acetone, carbon disulfide, chloroform, ether and petroleum ether. It is miscible with volatile oils and fixed oils except castor oil (74). A) Nonproprietary Names • BP: Liquid Paraffin • JP: Liquid Paraffin • PhEur: Paraffin, Liquid • USP: Mineral Oil B) Synonyms Avatech, Drakeol, heavy mineral oil and heavy liquid petrolatum C) Chemical Name and CAS Registry Number Mineral oil 8012-95-1 D) Empirical Formula and Molecular Weight Mineral oil is a mixture of liquid saturated aliphatic (C14–C18) and cyclic hydrocarbons obtained from petroleum. E) Functional Categories Lubricant, emollient, solvent and oleaginous vehicle. F) Applications in Pharmaceutical Formulation or Technology …show more content…

Chronic oral consumption of mineral oil may impair the appetite and interfere with the absorption of fat-soluble vitamins. Prolonged oral use should be avoided. Mineral oil is absorbed to some extent when emulsified and can lead to granulomatous reactions. Similar reactions also occur upon injection of the oil (77).Injection may also cause vasospasm. The most serious adverse reaction to mineral oil is lipoid pneumonia caused by aspiration of the oil (78). H) Incompatibilities Incompatible with strong oxidizing agents I) Stability and Storage Conditions Mineral oil undergoes oxidation when exposed to heat and light so stabilizers like butylated hydroxyanisole, butylated hydroxytoluene and alpha tocopherol may be added to retard oxidation. Mineral oil may be sterilized by dry heat and should be stored in an airtight container, protected from light in a cool and dry place. 3.2.8 Glyceryl

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