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Compare and contrast proto-oncogenes and tumor suppressor genes
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Cancer is a disorder where the body cells lose the ability to control growth. The cell cycle is a series of stages that happen within a cell that leads to division and duplication of DNA, that eventually produces two daughter cells. The development of this life changing disease occurs in the cell cycle, when checkpoints or regulations are ignored and the cell continues through the cycle. When a cell become damaged, it can lead to major problems.
The cell cycle begins with a phase called interphase, which includes G1, G0, and S, which are smaller stages within. G1 is the first gap phase where the cell increases in size, synthesize proteins, and produce RNA. At the end of this phase, there is a checkpoint, or internal regulator, that makes sure
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Cancer is related to the cell cycle because if a cell does not meant the checkpoint requirements and still continues through the cycle, it will become uncontrollable. During the synthesis stage of interphase, while the DNA should be replicating, an error can occur, which will lead to a mutated cell. Proteins that control transcription are often the cause because of the changed sequence. This one mutation can lead to an army of mutated cells. These cells can lead to tumor development and cancer. The P53 is a gene that codes for a protein that suppresses tumors. A tumor suppressor is a gene that protects a cell from one step on the path to cancer. It is extremely important in helping kill cells that could become cancerous. If there is a mutation to this gene, it will stop protecting you from cancer. Proto-oncogenes code for positive cell cycle regulators, but when mutated, turn into oncogenes, or genes that have the potential to become cancerous. Cancerous cells lose their specialized functions and produce more quickly. They ignore signals that tell them when to start and stop dividing. Eventually, they can take over tissues and grow without being regulated. Cancer cells have insufficient internal regulators and also cannot program cell death among mutated cells, this process is called apoptosis. When cancer cells don’t die, they keep dividing instead which can produce tumors, masses of rapidly dividing cells that can damage surrounding tissues. When cancer moves into other parts of the body and forms secondary tumors, it is called metastasis. Tumors that develop can be malignant, cancerous and invade and destroy healthy tissue, or benign, noncancerous and does not invade any other part of the body. Sometimes, cancerous cells can break away from a tumor and enter the bloodstream, which allows them to travel throughout the
Cell cycle events portray some differences between different living things. In all the three living things, their cells divide, a process referred to as mitosis. The mitosis stage differs and it encompasses four phases. During development, the cell cycle functions endlessly with newly created daughter cells directly embarking on their path to mitosis. Bacteria cells separate forming two cells after every thirty minutes under favorable conditions. However, the eukaryotic cells take quite longer compared to bacteria cells to develop and divide. Nevertheless, in both animals and plants, cell cycle is usually highly regulated to prevent imbalanced and excessive growth. Both animals and plants are known as eukaryotes meaning that their DNA exists inside their cells’ nuclei. Therefore, their cells as well as mitotic processes are similar in various ways (Eckardt, 2012).
..., while a cell undergoes cell cycle, when a cell comes in contact with another cell, it stops reproducing. However, cancer cells continue to duplicate repeatedly until there is a mass of cells or a tumor to form (see figure 9). Lastly, in cell division when there is a mutation or abnormality in the DNA, a normal cell stops dividing. However, a cancerous cell will continue to duplicate and form mutations (“Cell Biology and Cancer”). Also, cancer cells are harmful because they grow and duplicate with complete disregard to the functions and limitations of the body (see figure 10). Also, cancerous cells have the ability to spread through metastasis throughout parts of the body through the bloodstream. In terms of similar behavior to that of normal cells, cancerous cells also duplicate, but at a very different rate ("Cancer Cells vs. Normal Cells: What's Different?").
Cancer is the term used to describe a group of diseases consisting of hundreds of ailments and although there exists so many different types of cancer, they all begin in a similar way. The body is made up of over a trillion cells, and cancer is the uncontrolled growth of malfunctioning cells in the body (Dawson, 1996). “Normal body cells grow, divide, and die in an orderly fashion. During the early years of a person’s life, normal cells divide faster to allow the person to grow. After the person becomes an adult, most cells divide only to replace worn-out or dying cells or to repair injuries” (American Cancer Society, 2012).
First of all, interphase included three stages: G1 stage, S stage and G2 stage.Cells in the G1 stage will undergo the primary growth. Such as making more cytoplasm and organelles which makes the cells mature for use the next stage of chromosome replication. In this phase the cell is carries on its normal metabolic activities. Then, DNA copied performed in S stage. In the final stage of interphase is G2 stage which produced an organelles and proteins that need to be use in cell division.
All organisms are made of cells that grow by cell division. An adult human being consists of about 100000 billion cells. Dying cells are replaced by a large number of unceasingly dividing cells. A cell duplicates its chromosomes, segregates the chromosomes, and divides into two. These ordered sequences of events are called a cell cycle. 2001 Nobel Prize in Physiology or Medicine to Hartwell, Hunt, Nurse and 1998 Lasker Prizes in Basic Medical Research to Hartwell, Masui, Nurse have made important discoveries about the regulation of a cell cycle. Understanding the regulation of a cell cycle is seminal to understanding why and how cancer cells are formed. In this review, I focus on how these crucial discoveries made progress in understanding cell cycle regulation and leading to understanding cancer cell and cancer therapy.
Cell cycle is a complex mechanism that governs the cell growth and proliferation. Cell proliferation contributes to the continuity of life by producing cells, replenishing cells which undergone to cellular differentiation to acquired specialized phenotypes (function and morphology) to carry out living mechanism and towards the end-point-cell-death. Cell proliferation is determined by both extracellular signals such as cytokines and mitogen, and intrinsic cellular factors. Interactions of extracellular signals with intrinsic cellular factors trigger the biochemical events of cell proliferation. In the case of acquired immunity, proliferation is the important state after lymphocytes encountered to antigen presentation, and then leads to their effectors functions. Cell cycle regulators control the appropriate entry and progression throughout the cell cycle event. Thus, any cell cycle deregulation will potentially lead to tumourigenesis. (Malumbres and Carnero 2003)
The cell cycle is the process by which cells progress and divide. In normal cells, the cell cycle is controlled by a complex series of signaling pathways by which a cell grows, replicates it’s DNA and divides, these are called proto-oncogenes. A proto-oncogene is a normal gene that could become an oncogene due to mutations. This process has mechanisms to ensure that errors are corrected, if they are not, the cells commit suicide (apoptosis). This process is tightly regulated by the genes within a cell’s nucleus. In cancer, as a result of genetic mutations, this process malfunctions, resulting in uncontrolled cell proliferation. Mutations in proto-oncogene or in a tumour suppressor gene allow a cancerous cell to grow and divide without the normal control imposed by the cell cycle. A change in the DNA sequence of the proto-oncogene gives rise to an oncogene, which
Tumors are formed by the alteration of the body’s own cells. This can be caused by environmental factors such as radiation, like UV exposure, chemicals or viruses 1. These can disrupt genes that control growth and cause an increase in cell division and proliferation. Proto-oncogenes are those genes that control normal but essential cell processes that keep cell growth and death in check. Two important categories are apoptosis genes, which regulate cell death, and tumor suppressor genes, which decrease cell propagation 1 . If these genes were mutated to the point where they cannot produce a functioning protein, cell division would continue far past what it was supposed to and unhealthy cells would be allowed to live and continue to multiply. This is what creates a malignant tumor. Certain conditions in the body can also promote the growth of cancer cells. One of these is a deficiency of natural killer (NK) cells, which are able to kill cancer cells by creating a pore in the cell membrane with perforin and releasing granzymes into the cell. Low levels of perforin allow for tumor growth 1. Chronic inflammation can also ...
Healthy cells grow and divide in a way to keep your body functioning properly. But when a cell is damaged and becomes cancerous, cells continue to divide, even when new cells aren't...
The amount of DNA and organelles are doubled. Interphase is divided into three phases. The first stage is known as the growth stage, this follows cell division and is when cell organelles are synthesised. The second stage is known as the synthesis stage, this is when the DNA replicates. The finally the third stage is known as the 2nd Growth stage and this is when the centrioles replicate and energy stores increase.
The East Pennsboro elementary school raised money for a statue at a local park. The statue was a ring of children that were holding hands. There was one child missing; the link was broken. The statue was dedicated to East Pennsboro students that did not make it to their graduation. My sophomore year of high school inspired this piece of artwork.
Cancer develops when cells in a part of the body begin to grow out of
Cancer is a disease that affects human somatic cells. It causes the cells to divide uncontrollably and form masses known as tumors. There are two different types of cancer tumors. Some tumors are benign and other tumors are malignant. Benign tumors look similar to the tissues that they came from and develop slowly. The tumor remains in the same area that the tumor originated in. Malignant tumors are formed from cells that do not resemble the tissue that they came from. They vary in shape and size. This enables pieces of the tumor to break off and spread to other places in the body. Over the past few decades cancer has become a very prominent disease. There are many different types of cancer and many different causes for the the disease. Most cancers are because of a genetic mutation. The most common type occur when a cell is dividing. Proto-oncogenes, which are alleles in a normal cells, mutate to form oncogenes. These oncogenes cause cancer because they do not allow the cells to self destruct or become epistatic. There have been several research projects which have been testing epistatis.
The cell cycle is an undeniably fundamental part in the journey of a cell. Without it there would be no cell reproduction or growth. Through the process of mitosis and also meiosis which will be shortly discussed about, it will come to be known exactly just how important it actually is.
During this phase the DNA aka “deoxyribose nucleic acid” clone then forms chromatin. Chromatin is the mass of genetic material that forms into chromosomes. Interphase is divided into smaller parts: G1 Phase, S phase and G2 Phase. Throughout all the phases, the cells continuously develop by producing mitochondria, endoplasmic reticulum, and proteins. The actual division occurs during the S phase bur the G phases are mainly for the purpose of growing. Starting with the G1 phase the cell grows in preparation for certain intracellular components and DNA replication. This phase makes sure the cell is prepared for the process of DNA replication. It reviews the size and environment to ensure that is it ready to go, and cannot leave the G1 until it is complete. But what happens to a cell when it is not complete and cannot exit out of the phase? It will pause and transfer to phase G0. There’s no certain time to be in this phase but it will remain until it reaches the fitting size and is in a supportive surroundings for DNA replication. It will exit either G1 or G0 and there is no other way besides these. Then the cell will advance to the next phase which is the S phase. Synthesis, or more known as S phase is the section of the cell cycle when the DNA is wrapped into chromosomes then duplicated. This is a very important part of the cycle because it grants each of them that is created, to have the exact same genetic