Accutane Case Study

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Introduction When Accutane became available to consumers in 1982 as a treatment for recalcitrant nodular acne, it was regarded as a wonder drug. Researchers began investigating the risks of the medication only after news of adverse effects were reported to the Food and Drug Administration (FDA). Although Accutane has the ability to resolve persistent acne, the known side effects are of great importance to the consumer. Several studies have been conducted to elucidate the adverse effects of Accutane, as well as studies to show the medication’s efficacy and success rates. Accutane has high success rates in the cure of acne, with low recurrence rates. However, there are several adverse effects that every patient must be made aware of before they …show more content…

In their study, 40 patients were administered oral isotretinoin and were followed throughout their five month treatment. Prior to beginning treatment, comedogenic and inflammatory lesions were counted and recorded as baseline. At one, two and five months the acne lesions were recounted. By month one there was a 50% decrease of inflammatory lesions, and at the end of month two, there was a 50% decrease in comedones. Total improvement of inflammatory lesions was 86.12% at the end of treatment. 39.74% of the treatment group experienced excellent results, which is considered 80-100% resolution of total lesions. 55.27% of patients experienced good results, which is resolution of 50-79% of total lesions. With 95% of the treatment group experiencing good to excellent results, the researchers were able to prove statistically that these results are significant. While all of the patients saw improvement in their acne vulgaris, some did experience side effects. The most commonly reported adverse effects were scaling of the face (11%) and chelitis (5%). Other side effects experienced in this study include dryness, palmo-plantar peeling, and photosensitivity. Systemic side effects experienced by 5% of the patients were nausea, diarrhea and abdominal pain. None of the patients experiencing side effects required discontinuation of the medication and effects were treated

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