Topic: Thalassemia disorder Thalassemia is an inherited co-dominant blood disease. It is characterized by reduced synthesis of the hemoglobin and less red blood in children affected by this disorder. Hemoglobin is the means through which red blood cells carry oxygen in our body. We need two forms of globin genes to make beta globin chains in our body, one from each globin gene. If one or two of these genes are defective, it produces beta thalassemia which is the less severe form of this disease
Thalassemia is a blood disorder transferred through families. It occurs when the body makes less hemoglobin than needed or an unusual form of hemoglobin. Hemoglobin is the protein in red blood cells that carry oxygen. The disorder makes an excessive amount of destruction of red blood cells. This eventually leads to anemia. There are two main types of thalassemia. The first one is Alpha thalassemia. This occurs when a gene or genes related to the alpha globin protein are missing or mutated. It happens
unfortunately, parents also passed down genes for hereditary diseases like thalassemia. Thalassemia is a blood disorder passed down through families in which the body makes an abnormal form of hemoglobin, the protein in red blood cells that carries oxygen. The disorder results in excessive destruction of red blood cells, which leads to anemia (MedlinePlus, 2012). Hemoglobin is made up of Alpha globin and Beta globin, and thalassemia occurs when there is a mutation in a gene that helps control the production
in the world, Thalassemia is one of the more common known diseases. Thousands of infants with beta thalassemia are born each year. There are two different types of thalassemia related problems, alpha thalassemia, and beta thalassemia. The differences between the two types of thalassemia lie in the hemoglobin chain that is affected. For this paper the focus will be on beta thalassemia. Beta thalassemia is divided into three subcategories. The forms are thalassemia minor, thalassemia intermedia, and
Thalassemia is basically a name for similar groups of inherited blood diseases that involve missing or abnormal genes regarding the protein in hemoglobin which is the red blood cells that carry oxygen throughout the body. I will discuss the different types of Thalassemia, how Thalassemia is diagnosed, and the treatments available. I will also discuss the complications and side effects of the treatments, the disease’s causes and effects, and how it is more dominant in some parts of the world than
Thalassemia is an inherited blood disorder characterized by low amounts of hemoglobin and a low count of erythrocytes in the body. Thalassemia is caused by mutations in the deoxyribonucleic acid of cells, which makes hemoglobin. The mutations are passed from parent to child. The mutations vary depending on the type of Thalassemia inherited. The variation in the mutation occurs from the number of gene mutations, which are inherited, as well as mutation within the hemoglobin molecule. Clinical
I. Alpha thalassemia is a blood disorder that reduces the production of hemoglobin, which is the protein in red blood cells responsible for carrying oxygen throughout the body. Those affected experience a shortage of efficient oxygen-carrying red blood cells, causing anemia, and manifesting in the observable signs of: pale skin, weakness, fatigue, or serious complications when coupled with other illnesses. Thalassemia is a blood disorder passed down through families (since it is inherited siblings
The blood line journey of gene therapy towards curing Beta Thalassemia By Irya Maran What is Beta Thalassemia? Is it contagious? Are we eating the cause of thalassemia? Do we have it in our family? Are you a carrier of Beta Thalassemia Beta thalassemia is placed under the group of inherited blood disorders that can be transferred from both the genes of parents into their children. Mutations in HBB gene (Haemoglobin subunit beta) provides the instructions to beta-globin which is a subunit haemoglobin
term (Robertson, Kahn & Wagner, 2002). The Case of Ms. Yao and Mr. Zhao The case of Ms. Yao and Mr. Zhao is an example of when the concept of a savior sibling have been used. Ms. Yao and Mr. Zhao’s first child was diagnosed with Thalassemia. Thalassemia is an autosomal recessive genetic disorder of the blood. The parents decided to have a second child which was intended to be a savior sibling for his sister. Unfortunately, he also Another positive implication of the approach is that stem
The purpose of individual cultural assessment is to gain a greater understanding of the values and attitudes of another cultural group through an in depth interview with a member of the group of interest. For this assignment, the interviewee is a forty-eight years old Muslim woman from Bangladesh. Based on an extensive interview with Mrs. SK, the paper discusses many topics including cultural affiliations, cultural sanctions and restriction, religion and spirituality, health-related beliefs and
Nature vs Nurture The issues pitting nature against nurture are exceptionally significant for the gamut of discoveries that attribute an increasing proportion of traits and behaviours to one's genetic makeup. The resulting variety of physical shortcomings and limitations in each person has, for centuries, been countered by endeavours to improve or interfere where necessary, and every individual is consequently the product of a delicate middle path of balance between the two. The importance
the classroom research with the ultimate aim of promoting critical thinking in nursing students. In additional, I became involved in the children and their family with varied illness such as infectious disease (pneumonia, diarrhoea, HIV), Thalassemia, and Down’s syndrome . Mostly they are poorly education with low-socioeconomic status, and located inappropriately for access health care services that effect to their quality of life. I would like to apply my knowledge, research ability from
enlarged organs. The treatment depends on the type and severity of this disease. Treatment options include: bone marrow transplants, blood transfusions, medications and supplements and possible surgery to remove the spleen and/or gallbladder (Thalassemia, healthline,
Winland-Brown, Porter, & Thomas, 2015). This is a common form of anemia, affecting predominately women and should be considered as the diagnosis in this case study. 2. Microcytic anemia from Thalassemia Minor- Thalassemia is an inherited disease, which is broken down further into alpha or beta-globin thalassemia, based on which chains are affected in the suboptimal synthesis of the hemoglobin. Individuals affected by this type of anemia are from around the Mediterranean Sea area, Asia, and the western
Personal statement Nursing is such a diverse, challenging and worthwhile career that I really feel it is the right course for me. It is a vocation for people who are practical, conscientious, and reliable and who find it easy quickly to establish good, trusting relationships with new people. Since the role of the nurse is changing in Thailand, it is providing more opportunity for nurses to work toward the professional career by increasing the number of doctoral nursing students, expanding the
in an individual suffering from ATR-X syndrome, causing psychomotor retardation, α-thalassemia and the expression of abnormal phenotypes in both the genitals and face. A 2kb deletion mutation has been observed in the XH2 gene, removing both coding and non-coding sequences. This mutation results in the down-regulation of α - globin, this irregular haemoglobins are produced which directly results in α - thalassemia (Gibbons et al, 1995). The mutated globin proteins have a lower affinity with oxygen
Explain why the increased prevalence of sickle-cell disease among African Americans has more to do with the environmental factors than the skin color or other phenotypes used to define races. During a short break of solitude from studying, I explored and came across that the environment in which most African Americans reside in has a high occurrence of malaria virus. The malaria virus disease is contagious and when it contaminates someone with sickle cell traits, it cannot survive on the external
HPLC HPLC (High Performance Liquid Chromatography) is an analytical technique which separates a complex mixture of components into its specific individual components. It is a powerful tool in analysis, as it combines high speed with extreme sensitivity compared to traditional methods of chromatography because of the use of a pump which creates a high pressure and forces the mobile phase to move with the analyte in high speed. It is been used as a principle technology in various automated analyzers
raised many ethical concerns such as how the germline of that family changed and the psychological effect that this action will have on the embryo when it will grow up. China also recently genetically engineered non-viable embryos to rid them of thalassemia, which is a fatal blood disorder. The developing embryo was killed just after a couple of days of development, but this action did not occur without backlash from other countries (Knapton, par.5). Some scientists tried to rationalize that what
Child is a gift from God. Every parent hopes for a healthy child. Abnormalities in the fetus growth have become common nowadays. These abnormalities may be due to physical, radiation and chemical factors. The most common factor is due to genetic mutation, which causes mental retardation, abnormal body buildup and other conditions, which bring a lot of troubles in the future to the child themselves and their parents. Modern technologies and innovations in the medical field had developed a method known