contact with insulin and insulin receptor on some level, since insulin and insulin receptor are involved in the pathway that regulates glucose levels within the body. The insulin/insulin receptor pathway is vital in maintaining homeostasis within the body. As greater information is gathered on the insulin receptor structure and how it functions a better understanding of treatments for diabetes can possibly be unlocked. Insulin Receptor Gene The insulin receptor has several defined exons that encode
smooth muscles express five isoforms of muscarinic acetylcholine receptor MAchR (M1-M5)(Yuan et al., 2011), and seven classes of 5-hydroxytryptamine (5-HT, serotonin) receptors (5-HT1-5-HT7)(Briejer et al., 1997). These receptors are major drug targets and belong to the family of G protein-coupled receptor (GPCR) consisting of seven transmembrane spanning domains (Hannon & Hoyer, 2008; Yuan et al., 2011). Both MAchR and 5-HT receptors are essential in the regulations of smooth muscle contraction in
G protein-coupled receptors (GPCRs) are the largest class of transmembrane receptors, and collectively they respond to diverse stimuli to regulate nearly all physiological processes. Consequently, GPCRs are considered attractive drug targets, and drugs with agonistic, antagonistic, and modulating properties at GPCRs have been developed to prevent or treat numerous diseases and disease symptoms. Over the past decade, technical advances in the fields of pharmacology, physiology, and structural biology
psychological stress the Hypothalamic-pituitary-adrenal (HPA) axis is involved in the response. The HPA axis becomes activated when cortisol levels are increased, such as when stress levels increase (de Kloet, Joëls, & Holsboer, 2005). Glucocorticoid receptors (GCR) are affected by increased cortisol levels due to their high affinity to bind when the cortisol levels are intermediate to high. Furthermore the GCRs are involved in the termination of the stress response (de Kloet et al., 2005). GCRs are found
important roles in inter-neuronal communication. Receptor sites are made up of proteins and the ion channels in the cell membranes are proteins. The link between the receptor sites and the protein channels sometimes is the guanine nucleotide-binding protein, better known as G Protein. (1) The basic structure and function of these shall be explored in the following. In order for neuron communication to occur, the post-synaptic neuron must have receptor sites for the neurotransmitters released by the
2002. "Loss-of-function Variants of the Human Melanocortin-1 Receptor Gene in Melanoma Cells Define Structural Determinants of Receptor Function." European Journal of Biochemistry 269.24 : 6133-141. Print. Rees, J.L. “The genetics of skin and hair pigmentation in man.” The University of Edinburgh :UK 842-843 (2003) Valverde, P., E. Healy, I. Jackson, J. L. Rees, and A. J. Thody. 1995. "Variants of the Melanocyte–stimulating Hormone Receptor Gene Are Associated with Red Hair and Fair Skin in Humans
effects on many organs and tissues. The Insulin Receptor and Mechanism of Action Like the receptors for other protein hormones, the receptor for insulin is embedded in the plasma membrane. The insulin receptor is composed of two alpha subunits and two beta subunits linked by disulfide bonds. The alpha chains are entirely extracellular and house insulin binding domains, while the linked beta chains penetrate through the plasma membrane. The insulin receptor is a tyrosine kinase. In other words, it functions
creating pressure waves in the endolymph inside the cochlear duct. These waves then causes the membrane to vibrate, which in turn cause the hairs cells of the spiral organ to move against the tectorial membrane. The bending of the stereo cilia produces receptor potentials that in the end lead to the generation of nerve impulses. The External or Outer Ear - comprises of the auricle or pinna which is the fleshy part of the outer ear. It is cup-shaped and collects and amplifies sound waves which then passes
hallucinogens) stimulate 5-HT2A receptors (Kalat, 2004). Activation of these receptors causes cortical glutamate levels to increase. This is presumed to be a result of a "presynaptic receptor-mediated release" from neurons in the thalumus (Nichols, 2004). Early studies proposed that LSD antagonized the effects of serotonin on peripheral tissues. It was later proposed that the psychoactive properties of LSD may be a result of the blocking of serotonin receptors in the central nervous system
(138). Dwarfism, according to the Greenberg Center, is the result of a genetic condition caused by a new mutation or a genetic change.In 1994, the Center reports that the gene for achondroplasia was found and labeled “fibroblast growth factor receptor 3 (FGFR3).”This discovery of at least one cause of dwarfism was a breakthrough because dwarfs in the past were simply regarded as inexplicable freaks.But now there is biological evidence of a gene, in which,“the mutation, affecting growth, especially
(blood stream). If there were no receptor sites for the hormones in the body, then they would continue to flow along the river and probably not make their destination. However, there are systems of receptor sites that enable specific hormones to bind in specific places. Structure also plays a major role in determining which hormones are able to bind to which receptors. When these “messages in bottles'; reach their appointed destination, the binding into the receptor site causes a cascade of reactions
sense data. We will attempt to demonstrate that Berkeley's description of our experience at the end of the water experiment is inauthentic, that it is not so much a description of an experience as a reconstruction of what we would experience if the receptor organs (the left and right hands) were objects existing in a space partes extra partes. Our argument is that there is nothing in our experience of the illusion to suggest that under normal conditions perception does not reach the world itself.
Serotonin and Its Uses Serotonin (5-hydroxytryptamine, 5-HT) is a neurotransmitter in the brain that has an enormous influence over many brain functions. It is synthesized, from the amino acid L-tryptophan, in brain neurons and stored in vesicles. Serotonin is found in three main areas of the body: the intestinal wall; large constricted blood vessels; and the central nervous system. The most widely studied effects have been those on the central nervous system. The functions of serotonin are
and deepening of the voice. The hormone produces these results when it is absorbed from the bloodstream by certain types of cells. Molecules of testosterone fit into receptor sites located inside the cells, just as a key fits into a lock. When the receptor site is filled , the cell is activated. There are a certain number of receptor sites in each cell. If only a few them get filled, the cell will respond at a low level. If all of these sites are filled, the cell produces its maximum response (http://www
olfactory system. There are between 500 and 1000 unique protein receptor genes which are expressed only in the olfactory epithelium. These receptors each respond to a unique odorant or to a unique feature on an odorant molecule (epitopes). It is suggested that there is a one - to - one relationship between a specific odorant, its protein receptor, and the sensory neuron: that is, any given sensory neuron expresses only one type of receptor and is therefore responsive to only one kind of odorant. Each
virus travels down the digestive tract to the small intestine where it replicates itself in the B-cells and T-cells of the gut mucosa lining the intestine. Spread and Replication Poliovirus binds to a specific cell surface protein, polio virus receptor (PVR). This protein is an immunoglobin which contains three loops, Ig domains. Polio binds... ... middle of paper ... ...the polio vaccinations contaminated with SV40 and its link to cancer. Resources Flint, S., Enquist, L., Krug, R., Racaniello
In John Steinbeck’s The Chrysanthemums, the reader is introduced to the seemingly timid and shy Elisa Allen. Elisa is routinely planting her yearly sets of Chrysanthemums, which appear to be the sole receptor of her caring and gentle touch, but all the while it is evident that “the chrysanthemum stems seemed too small and easy for her energy.” Her hidden eagerness seems not only out of place, but out of touch with her dry and wilted surroundings, of which her husband, Henry, abruptly interrupts her
best-known opioid around, and arguably one of the most addictive substances known to man. Opiates and opioids (hereafter generically referred to as opioids) function by attaching to receptor sites in the body called mu-receptors, which are primarily located in the brain and the digestive system. When these receptors are activated in the brain they produce a rush of euphoria and a groggy state of well being (it is interesting to note that studies have shown that this action does not eliminate the
external information through pathways that are not explicitly sensory. However, our understanding of sensation as it stands now depends on the existence of receptors within the nervous system that are specified for the respective types of sensation (1,2). An input can only be received and integrated if there exists within a system the proper kind of receptor, be it mechano-... ... middle of paper ... ... 10) IRVA: The History of Remote Viewing http://www.irva.org/papers/CRVHistory.shtml 11) IRVA:
of light that focus on specific places on the retina. This light-sensitive tissue that lines the back of the eye consists of interconnected neurons. The three diff erent types are receptor cells, bipolar cells and ganglian cells. When photoreceptors are stimulated, they change in structure of photopigments in the receptors and transduce light input into neural activity. (2) Electrical stimulus trave ls down the axon of bipolar cells to the ganglian cells. The ganglian cells are activated through nerve