high blood pressure. If hypertension is left untreated, it can cause severe health problems such as stroke and heart failure. In order to treat hypertension, the drug Losartan is used. Losartan is an angiotensin-II receptor antagonist (AIIRA). In other words, it can also be known as angiotensin receptor blocker. (Allen 2012) There are generally two categories of hypertension, primary hypertension and secondary hypertension. The causes of primary hypertension are usually unknown and it develops gradually
cardiovascular system, reninangiotensin-aldosterone system and sympathetic nervous system (Foex & Sear, 2004). This research paper aims to study the dysfunction of renin-angiotensin-aldosterone system in pathophysiology of hypertension and the effects of an antihypertensive drug, losartan on the angiotensin II type 1 receptors in response to the disease. Pathophysiology of hypertension Renin is a type of protein enzyme secreted by the juxtaglomerular apparatus of the kidneys when the blood pressure
through the renin-angiotensin-aldosterone regulatory pathway. The kidneys, which are a major location for water retention regulation (and through changes in blood volume regulate blood pressure), notice decreases in blood pressure and release renin, an enzyme that alters the conformation of proteins, which converts angiotensinogen into angiotensin I. Next, angiotensin I is altered into the conformation of angiotensin II by the action of angiotensin converting enzyme. Angiotensin II then causes many
development of vascular cognitive impairment and vascular dementia [1, 2]. Angiotensin I-converting enzyme (EC 3.4.15.1; ACE) plays an important role in the rennin-angiotensin system and it is a carboxyl-terminal dipeptidyl exopeptidase that catalyzes the conversion of angiotensin I to angiotensin II [3-6]. ACE converts an inactive form of decapeptide, angiotensin I, to a potent vasoconstrictor, octapeptide, angiotensin II, in addition; since the ACE is a multifunctional enzyme it also catalyzes the
RAAS (Renin Angiotensin Aldosterone System) plays a role in the homeostatic process such as blood pressure and fluid volume control1. Renin is secreted in the blood from cells that are lining the glomeruli of the kidneys. The renin-secreting cells are sensitive to changes in blood flow and blood pressure. Angiotensinogen, a glycosylated protein that is primarily synthesized and secreted by the liver as well as other tissues is the sole precursor for angiotensin peptide. Renin catalyzes the conversion
INTRODUCTION →Bartter’s Syndrome, or hypochloremic metabolic alkalosis, is a disorder involving a set of three other closely related disorders. These rare congenital Bartter-like syndromes share many pathophysiological simularities, but differ in the age of onset and the location of genetic problems in the nephron (Guay-Woodford). →Most of those affected are diagnosed at a very young age, usually within the first 30 weeks of gestation but as late adelescence, and there does not appear to be
Committee of the Spanish Society of Cardiology. Vol. 65, Revista Española de Cardiología (English Edition). 2012. 28. Pitt B, Ao J, Ferreira P, Zannad F. Mineralocorticoid receptor antagonists in patients with heart failure: current experience and future perspectives. 29. Yang J, Young MJ. Mineralocorticoid receptor antagonists—pharmacodynamics and pharmacokinetic differences. Curr Opin Pharmacol.
between meals. TPN @ 79cc/hr 12hr around the clock through PICC line MEDICAL DIAGNOSIS: Empyema, Hemoptysis, Necrotizing pneumonia, Aspergillosis (Aspergillus fumigatus) cachexia secondary to malnutrition/infection, hypothyroidism, Diabetes Type II melitius , and... ... middle of paper ... ...trol. Home health aide / RN needs to understand this after discharge. OUTCOME/GOAL STATEMENT: Short Term: Pt will verbalize feelings of concern regarding at home maintenance of self with SO prior