through the renin-angiotensin-aldosterone regulatory pathway. The kidneys, which are a major location for water retention regulation (and through changes in blood volume regulate blood pressure), notice decreases in blood pressure and release renin, an enzyme that alters the conformation of proteins, which converts angiotensinogen into angiotensin I. Next, angiotensin I is altered into the conformation of angiotensin II by the action of angiotensin converting enzyme. Angiotensin II then causes many
body. One of these proteins was Angiotensin Converting Enzyme. The reason that this protein is important is because of the fact that it
The renin-angiotensin system (RAS), also known as renin-angiotensin-aldosterone system (RAAS) is well-known for its role in regulating blood pressure, fluid volume, and capillary perfusion. It is one of the most important systems studied by those interested in the cardiovascular system and those involved in the pathogenesis of heart and renal diseases. The renin-angiotensin system exists in two frameworks: a circulating system and multiple local, tissue-specific systems. Local RAS have been found
development of vascular cognitive impairment and vascular dementia [1, 2]. Angiotensin I-converting enzyme (EC 3.4.15.1; ACE) plays an important role in the rennin-angiotensin system and it is a carboxyl-terminal dipeptidyl exopeptidase that catalyzes the conversion of angiotensin I to angiotensin II [3-6]. ACE converts an inactive form of decapeptide, angiotensin I, to a potent vasoconstrictor, octapeptide, angiotensin II, in addition; since the ACE is a multifunctional enzyme it also catalyzes
as high blood pressure. If hypertension is left untreated, it can cause severe health problems such as stroke and heart failure. In order to treat hypertension, the drug Losartan is used. Losartan is an angiotensin-II receptor antagonist (AIIRA). In other words, it can also be known as angiotensin receptor blocker. (Allen 2012) There are generally two categories of hypertension, primary hypertension and secondary hypertension. The causes of primary hypertension are usually unknown and it develops
such as the cardiovascular system, reninangiotensin-aldosterone system and sympathetic nervous system (Foex & Sear, 2004). This research paper aims to study the dysfunction of renin-angiotensin-aldosterone system in pathophysiology of hypertension and the effects of an antihypertensive drug, losartan on the angiotensin II type 1 receptors in response to the disease. Pathophysiology of hypertension Renin is a type of protein enzyme secreted by the juxtaglomerular apparatus of the kidneys when the
RAAS (Renin Angiotensin Aldosterone System) plays a role in the homeostatic process such as blood pressure and fluid volume control1. Renin is secreted in the blood from cells that are lining the glomeruli of the kidneys. The renin-secreting cells are sensitive to changes in blood flow and blood pressure. Angiotensinogen, a glycosylated protein that is primarily synthesized and secreted by the liver as well as other tissues is the sole precursor for angiotensin peptide. Renin catalyzes the conversion
Cardiovascular disease is currently the nation’s leading non-communicable cause of morbidity and mortality. According to the American Heart Association, the most common form of cardiovascular disease is coronary artery disease, a condition in which the heart’s blood supply is reduced due to a narrowing of the coronary arteries. These arteries play a significant role in regulating the flow of oxygenated blood to the heart. As blood circulates through the arteries, it exerts a force against the vessel
RAAS System The renin-angiotensin-aldosterone system (RAAS) consists of a complex endocrine regulatory pathway and several less studied local autocrine/paracrine systems. RAAS is an important part of many pathologic conditions including hypertension, heart failure, and renal disease. The classical endocrine RAAS is activated predominantly by decrease in renal blood flow. This system works primarily through the heart, blood vessels, and Kidneys to regulate blood pressure; and controls water and electrolyte
thickening and hardening of the walls of the arteries, occurring in old age. Four control systems have a job in maintaining blood pressure. These are the arterial baroreceptor and chemoreceptors’ system, regulation of body fluid volume, the renin- angiotensin system, and vascular autoregulation. Primary hypertension mostly occurs from a defect or malfunction in some or all of these
Hypertension is a medical condition wherein the blood pressure stays higher than 140 over 90 mmHg.* When blood pressure remains elevated for an unknown cause, it is called primary (also known as essential or idiopathic) hypertension. On the other hand, high blood pressure as a result of another complication such as tumor, endocrine or kidney diseases it is called secondary hypertension.* Risk factors which are likely to contribute to high blood pressure include age (more prone to people age 60 years
INTRODUCTION →Bartter’s Syndrome, or hypochloremic metabolic alkalosis, is a disorder involving a set of three other closely related disorders. These rare congenital Bartter-like syndromes share many pathophysiological simularities, but differ in the age of onset and the location of genetic problems in the nephron (Guay-Woodford). →Most of those affected are diagnosed at a very young age, usually within the first 30 weeks of gestation but as late adelescence, and there does not appear to be
Health Benefits of Exercise Physical exercise has long been regarded as a positive thing for the human body - but what actually constitutes exercise? Exercise can be dissected into two major categories, aerobic exercise and anaerobic exercise. Aerobic exercise is usually a lower intensity, longer endurance form of energy usage that raises the respiratory and pulse rate of the individual. The major physiological classification of this type of exercise is that it accesses the aerobic energy generation
Explain your response. To expand circulating blood volume, isotonic saline is infused intravenously. Sodium is largely confined to the ECF, so most of the effects of saline leaves to enter the interstitial space Explain the renin-angiotensin mechanism. The renin-angiotensin system is a group of related hormones that act together to regulate blood pressure (UKRO, 2015).Working with the kidneys is the body’s most important long-term blood pressure regulation system. Explain how ADH compensates for blood
Hypertension, commonly known as high blood pressure, is more often found in males than in females as age increases then reverses around the age of 65. There is about 67 million of American adults that have high blood pressure, which is 31 percent, that comes down to one in every three American adults (High Blood Pressure Facts, CDC.com). Hypertension is the force of blood pushing against the walls of the arteries as the heart pumps blood. Blood pressure is determined by the amount of blood your
1) What 4 etiologies in this case are responsible for causing hyperkalemia? How do each of the etiologies cause hyperkalemia? a) CKD- This patient has a history of Stage 5 renal failure, which requires him to receive regular dialysis. At this stage, oliguria occurs, resulting in a decreased renal excretion of potassium and a decrease of glomerular filtrate. Since this patient has not received regular dialysis (last performed x 5 days ago), metabolic acidosis may have occurred causing an increased
The human body regulates blood pressure using the cardiovascular system and central nervous system in order to maintain homeostasis through the following steps. The three components involved in the cardiovascular system include; cardiac output (CO), peripheral resistance and blood volume. Cardiac output refers to the amount of blood pumped by the heart per minute. Peripheral resistance is the resistance of the arteries to blood flow. As the arteries constrict, the resistance increases verses arteries
which could be attributed to hypovitaminosis D. The mechanisms behind these diseases are not entirely understood, however many suggest that Vitamin D regulates bodily functions through its effects on parathyroid hormone production and the renin-angiotensin system. Vitamin D deficiency is thought to cause increased inflammatory, parathyroid effects and endothelial function failure while also increasing vascular rigidity. A close link between vitamin D and cardiovascular diseases has been established
Left Ventricular Systolic Dysfunction (LVSD, but commonly referred to as heart failure) is a chronic, progressive cardiac syndrome in which a damaged heart fails to beat efficiently and deliver enough blood to meet the body's needs. Although coronary heart disease (CHD) is the most common cause, for example, myocardial infarction, and many of the conditions are intertwined, there are several other causes of heart failure including cardiomyopathies, hypertension and valve disease. Cardiomyopathies
Hypertension (HTN), also known as high blood pressure, is the persistent, chronic elevation of blood pressure force in the arteries that can cause health problems, and damage to the body’s organs. There are two main types of hypertension consisting of, primary (essential) and secondary (Khan, et al., 2013). Primary hypertension is a gradual increase in blood pressure without a known cause or contributing underlying disease. Secondary hypertension is an acute onset, or a spike in blood pressure