Introduction
Animals may be used for experimentation to gain knowledge about human diseases and knowledge on how to cure them. Animals like mice and rats share physiological and generic similarities with humans. Animal experimentstion is helpful for elaborating medical science.
In the past years, scientists have been discovering how to clone animals. They tried their best to make this possible, but failed to do so. Until in the year 1996, Ian Wilmut, an English embryologist, together with Keith Campbell, cloned a sheep which was named Dolly.
Dolly was bred with a Welsh Mountain Ram and produced six lambs in total. Her first lamb was named Bonnie, then she produced twin lambs named Sally and Rosie, and she also gave birth to the triplets named Lucy, Darcy, and Cotton. In the autumn of 2001, at the age of four, Dolly developed arthritis and began to walk stiffly, but it was successfully treated with anti-inflammatory drugs.
Dolly was euthanized on the 14th of February 2003 because she had a lung disease and severe arthritis. She is a Finn Dorset, which has a life span of around 11 to 12 years, but Dolly only lived 6.5 years. “Roslin scientists stated that they did not think there was a connection with Dolly being a clone, and that other sheep in the same flock had died of the same disease. Such lung diseases are a particular danger for sheep kept indoors, and Dolly had to sleep inside for security reasons.”
Scientists tried to clone different kinds of mammals including pigs, deer, horses, and bulls after a successful experimentation of Dolly. Some were successful, but some also failed.
This paper will explain everything about cloning: its kinds and methods, how it is done, and some of the advantages and disadvantages. ...
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• “Animal Research: The Ethics of Animal Experimentation.” Huntington’s Outreach Project for Education, at Stanford. July 6, 2010.
• “Cloning.” National Human Genome Research Institute. June 12, 2012.
• “Cloning=Cruelty.” Compassion in World Farming. 2012.
• “Cloning - Mirror of Today, Reality of Tomorrow.” Oracle, ThinkQuest, Education Foundation. 2001.
• “Dolly (sheep).” Wikipedia: The Free Encyclopedia. January 16, 2014.
• “What are some types of Cloning?” Wise Geeks.
... dolly the sheep was a success because they could see that Dolly’s face was clearly a whiteface poll Dorset and not a Scottish blackface. She was cloned at the Roslin Institute in Scotland and lived there from her birth in 1996 until her death in 2003 when she was six. She was born on July 5, 1996 but not announced to the world until February 22, 1997. Her stuffed remains were placed at Edinburgh's Royal Museum, part of the National Museums of Scotland. Ever since Dolly the sheep, there has been so many other mammals cloned like frogs, which are said to be the easiest to clone.
This is explained by Craig Freudenrich. He discusses this on the website HowStuffWorks. Freudenrich tells of how Ian Wilmut and his colleagues successfully cloned Dolly the sheep at the Roslin Institute in Midlothian, Scotland. Dolly the sheep was the world's first successfully cloned mammal, cloned from an adult somatic cell. He writes how after Dolly, scientist have been cloning animals like cows and mice. “They rely on transplanting the genetic information from a specialized cell into an unfertilized egg cell, whose genetic information has been destroyed or physically removed.” (How Cloning Works) This information is very enlightening to anyone who questions how cloning works. Furthermore it secures the information needed to inform the general public of what they need to know to have a responsible and appropriate
In recent decades, questions about genetic engineering, genetic modification, and cloning of animals and humans are on the minds of many. On February 27, 1997 when Dr. Ian Wilmut and his team sent chills down our spine with the announcement of the first successfully cloned sheep Dolly. At this time the reality of animal cloning stared us in the face while the human cloning was just around the corner.
Rolling, Bernard E. "Animal Research: A Moral Science." Emboreports.com. N.P. Aug. 2008. Web. 21 Nov. 2011.
Cloning is, and always has been an extremely contentious topic. To some, the ethical complications surrounding it, are far more promiscuous than what scientists and medical experts currently acknowledge. Cloning is a general term that refers to the process in which an organism, or discrete cells and genes, undergo genetic duplication, in order to produce an identical copy of the original biological matter. There are two main types of artificial cloning; reproductive and therapeutic, both of which present their respective benefits and constraints. This essay aims to discuss the various differences between the two processes, as well as the ethical issues associated with it.
The Roslin Institute, is known for being one of the world's primary research centers on farm and other animals. In 1996, Professor Wilmut, along with his assistant, Keith Campbell, made history by creating the first organism to be duplicated (cloned) from adult cells. Their creation infamously became known as Dolly, the first cloned adult sheep.
Even though cloning methods have been in use for an extended period of time, the idea of a clone was never thought to be realistic until recently. For thousands of years, humans have been cloning plants through asexual propagation. This is simply the process of stem cutting or grafting a mammal was performed in Switzerland nearly 20 years after the carrot plant where mice cells were cloned. Later, in 1997, Dolly the sheep’s mammary cells were cloned (Lee). This was a major success for science because it was the first time an adult cell was used in which results in a clone of the previous generation of the plant and is still a method used today. It wasn’t until 1958 when modern cloning began with a carrot and in 1964 when scientist John Gurdon started the beginning of animal cell cloning of toad tadpoles. The first successful clone of embryonic cell. After scientists gained a greater knowledge of the process of cloning, they realized that it could possibly be used to benefit the world. In 2001, the first endangered species, the bull gaur, was cloned, and in...
Human and animal cloning traces back to a long time in history. There has been many changes and improvements throughout the times. For example, cloning had started with smaller, easier subjects to work with. Researchers have found that "cloning of plants (such as growing a plant from a cutting) has been a common practice of mankind for hundreds and perhaps thousands of years" ("History of Cloning"). In earlier times, many scientists used plants to practice on and perfect before moving on. After they had perfected this, than they would move on to more complicated subjects. In addition, animals became the next experiments for the science of cloning. " Even cloning of small animals has a long history dated back to the 1960s; human cloning had not been thought possible until the successful cloning of the first mammal, Dolly the Sheep, in 1997" ("History of Cloning"). Dolly the Sheep helped scientists be convinced that ...
“The bill would ban human cloning, and any attempts at human cloning, for both reproductive purposes and medical research. Also forbidden is the importing of cloned embryos or products made from them”; these are the views of a US representative, Ken Calvert. Humans have been cloning plants and small animals like invertebrates since centuries but the idea of human cloning is controversial and a topic of discourse. Human Cloning refers to the asexual production of a human being from an ancestor to which it would be genetically identical. Scientists started their research on cloning animals in 18th century. August Weismann, In 1880s, proposed that the genetic information of a cell would diminish with every cell division. Hans Spemann challenged his idea and in his book entitled “Embryonic Development and Induction” talked about a fantastical cloning experiment which later became a basis for animal cloning. He called it a “nuclear transfer experiment” and suggested that cloning could be carried out by transferring nucleus from a cell into an enucleated – a cell whose nucleus has been removed – egg. John Gurdon, at Oxford University, put forward his idea and cloned South African frogs from an intact nucleus of a Xenopus tadpole. After Gurdon, an English embryologist, Dr. Ian Wilmut started research on cloning of mammals and cloned a sheep named “Dolly” which became an important scientific and technological breakthrough. With the birth of Dolly, the world realized that animal cloning was no longer a dream or an element of a science fiction movie and the debate about human cloning captured much attention.
10. Love, Jamie, “The Cloning of Dolly.” Science Explained 27 November, 1997; 18 July, 2007
...the scientists creating dolly starved the donor sheep’s cells to make sure they were inactive. The scientists then committed somatic cell nuclear transfer and took the inactive donor cells and fused them with an egg without a nucleus from a different bread of sheep. Then, continuing to use the reproductive cloning procedure, the scientist implanted the egg into a third breed of sheep’s uterus. When Dolly came to full term and was born, the scientist immediately recognized that the lamb looked very similar to the breed of the sheep who donated the DNA, and nothing like the sheep who donated the egg or gave birth to the lamb. Later on, DNA tests confirmed that indeed, Dolly was an exact clone of the DNA donor. On April 13, 1998 Dolly gave birth to a healthy lamb, proving her health to be standard. She would eventually have two more pregnancies and have five more lambs.
In conclusion, the thesis of this paper is supported by three contentions. First, if successful, cloning can have a lot of positive technological advancements that would help humanity. Second, Dolly, the first cloned mammal, inspired many scientists to speculate a new era in cloning technology and raise hopes for future probability in which human cloning was possible. Finally, at the center of the controversy, surges the closest thing to a clone that lives a healthy and regular life, identical twins. The promise of cloning at any level can revolutionize the world, and change it for the better, but are we are not ready for human trials. The failure rate is overwhelming; we should master cloning animals with close to 100% success rate before starting human cloning trials.
Research on animals is deemed necessary to develop vaccines, treatments, and cures for diseases and to ensure that new products are safe for humans to use. “The development of immunization against such diseases as polio, diphtheria, mumps, measles, rubella, pertussis, and hepatitis all involved research on animals […]” (AMPEF 1). Scientists have found many drugs by means of animal experimentation. To some people, animals are viewed as better test subjects than anything else. Scientists can control many aspects in an animal’s life such as their diet, the temperature, lighting, environment, and more. Animals are biologically similar, but not identical to humans and can form some of the same health problems. When these health problems are injected into an animal it can have the same physical reactions as a human could.
been made possible but yet a majority of them have died in early stages of development or after birth according to the study of the cloned sheep, Dolly (Magalhães 1). Those who make it suffer from several defects acquired from birth (Magalhães 1). During recent experimentation it took scientist Ian Wilmut of the Roslin Institute in Edinburgh, Scotland, and his colleagues who created Dolly (a cloned sheep) 277 tries before they got a healthy, feasible lamb (Human Cloning 1). Due to the complication of human cloning even more deaths and deadly birth defects can be expected (Human Cloning 1). Even though human cloning has never been performed, one likely possibility is that babies born through this process will as well feature lethal birth defects (Magalhães 1).
Dolly, a sheep, is the first cloned mammal created. She was born twenty years ago and died six years later from osteoarthritis. Dolly had joint and lung problems reminiscent of old age. When researchers examined the length of her telomeres, they found biological age surpassed her chronological age. “Some worried that this meant clones would age prematurely, carrying the same biological clock as the adult cells they’d been created from,” evidence article 2 says.