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Stem Cell Research
One of the most popular clinical studies being researched these days is stem cell transplantation. Until recently, moral issues of states and countries haven't allowed research to expound deeply into the unknowns. Within the last ten years though, scientists have made leaps and bounds in finding out concrete facts that this stem cell research has supplied. Tommy G. Thompson, Secretary of Health Services states, "I believe it will open up a world of opportunity for scientists, not only at the NIH, but elsewhere, because it demonstrates a cooperative atmosphere among academia, the private sector, and government that will allow us to move ahead" ("sign stem"1). New ways of conducting stem cell research have made the healing and repairing treatment for many diverse applications.
To prove their point, scientists have broken down the basic facts of their studies throughout the last ten years. Embryonic stem cell transplantation is a related course of cells that are in charge of certain functions and systems of the body. The cells used in the transplantation process are contrived from "cryopreserved suspensions" from the fetal liver, thymus, bone marrow, spleen, brain, and the pancreas. Introducing these cells to the body can be approached in different ways. The first step taken is engrafting or multiplying cells in the affected area. These cells will then supplement missing or declining cells and replace/repair missing functions of the body. Production then commences with considerable amounts of biologically active substances such as nerve growth factor, tumor necrosis factor and interleukins etc. When these cells have been transplanted, they are capable of migrating, establishing intercellular links and responding to various effects. However, because of their immature transplantation to the human body, these cells cause a weaker immune response than mature cells.
Alexander Smikodub, a doctor of Medical Science at the National Medical University states, "cells that we use are not considered by the immune system of the recipient as foreign, therefore, they can survive, multiply, and develop full function in the body of a new host" Smikodub). These cells can then survive and multiply, capable of lasting for months and years in the body of the recipient. In the areas where tissue or organs have been damaged or lost, they substitute the lack of functional activities. These cells can also produce new generations of cells that are needed by the patient. When strategically placed, they can support, restore and replace the functions of their specialization in the body.
Keiger, D. (2010, June 2). Immortal Cells, Enduring Issues. Johns Hopkins Magazine. Retrieved from http://http://archive.magazine.jhu.edu/2010/06/immortal-cells-enduring-issues/
The body is composed of cells, which form the basic unit of life. Unique cells found in the body are the stem cells. These cells are biological cells that are not specialized for particular functioning in organisms. They can be distinguished since they have the ability to differentiate or divide into multiple body cells, and their ability to replicate self. They are unique in the way they can renew themselves by undergoing cell division when inactive for a long period. It is also possible to induce stem cells to organs or tissue cells under some conditions. When the cells divide, they replenish the cells in a living organism. They serve as an internal system that repairs and replaces the tissues that are worn out.1 Dividing cells may remain as stem cells or become specialized in their functions, for instance red blood cells, brain or muscle cells.
Skloot gains credibility by describing researchers who took different approaches to culturing cells. A French surgeon at the Rockefeller Institute named Alexis Carrel grew his “immortal chicken heart.” Many researchers believed it was not possible to have tissues living outside of the body, and Carrel proved them wrong by growing a sliver of chicken-heart tissue in culture successfully. Doctor George Gey was the head of tissue culture research at Johns Hopkins Hospital where Henrietta was treated for her cancer. Dr. Gey, along with his wife, had spent years trying to grow cells outside of the human body in search of the cause and cure for cancer. Most cells they tested either died or hardly grew. In The Immortal Life of Henrietta Lacks, Skloot writes, “The Geys were determined to grow the first immortal human cells: a continuously dividing line of cells all descended from one original sample, cells that would constantly replenish themselves and never die” (30; ch. 3). Little did they know, they were about to grow the first immortal human cells, using cells they removed fro...
Could you imagine being able to create new organs, tissues, muscles, and even food? With embryonic stem cell technology, believe it or not, these things are possible. Stem cells are the body's raw materials. Specifically, they are cells from which all other cells with specialized functions are generated. Under the right conditions in the body or in a laboratory, stem cells can divide to form more cells called daughter cells. These daughter cells either become new stem cells or turn into specialized cells with a more specific function, such as blood cells, brain cells, muscle cells or bone cells. The possibilities are almost endless. The debate and main issue with this technology is that the actual stem cells come from embryos. Embryos are an unborn or unhatched offspring in the process of development. Although there is controversy surrounding these cells, embryonic stem cells should continue to be researched and used, because they have so much potential.
" An Overview of Stem Cell Research | The Center for Bioethics & Human Dignity."
“Through the isolation and manipulation of cells, scientists are finding ways to identify young, regenerating ones that can be used to replace damaged of dead cells in diseased organs. This therapy is similar to the process of organ transplant, only the treatment consists of the transplantation of cells rather than organs. The cells that have shown by far the most promise of supplying diseased organs with healthy cells are called stem cells.” (Chapter Preface)
Stem Cells: What, How and Why? Stem cells are infinitely valuable when considering their potential applications in the medical profession. While current legislative restrictions have halted the development of new ?stem cell lines? to any agency or company that receives any form of governmental grants, there is no question that the medical profession is standing at the brink of a new era of technological advancements in healthcare and research.
Stem cell therapy is a controversial topic that falls on the list of things not to discuss over thanksgiving dinner, very much like religion and politics. While the potential of stem cell research and therapy stand to make leaps of progression in cures for disease like Cancer and Alzheimer’s; Pros, Cons and morality still surround the issue.
Currently, the limitations on research are too restricting, as researchers are limited to resources already gathered. There are sixty existing stem cell lines today, already derived from embryos. Researchers are to only use these lines. These limitations severely hinder stem cell research. The government, especially President Bush, should re-evaluate stem cell research.
Stem cell research began in 1956 when Dr. E Donnall Thomas performed the first bone marrow transplant (“Adult stem cells are not more promising,” 2007). Since that time, research has evolved into obtaining cells from a variety of tissues. According to stem cell research professors, Ariff Bongso and Eng Hin Lee (2005), “Stem cells are unspecialized cells in the human body that are capable of becoming cells, each with new specialized functions” (p. 2). Stem cells are in various adult tissues, such as bone marrow, the liver, the epidermis layer of skin, the central nervous system, and eyes. They are also in other sources, such as fetuses, umbilical cords, placentas, embryos, and induced pluripotent stem cells (iPSCs), which are cells from adult tissues that have been reprogrammed to pluripotency. Most stem cells offer multipotent cells, which are sparse...
Imagine that there is a cure for nearly every ailment that affects the human race. Imagine that you could help the terminally ill, put those you love out of pain, and cut the healing time of an enormous number of serious illnesses in half. Imagine a world in which pain and suffering would be nearly nonexistent, and the people you love can live safe from the fear of crippling injury. Now what if I told you that this utopia was a fast approaching reality? Everything from serious life threatening burns to lymphoma, AIDS, Alzheimer’s, Muscular Dystrophy, Parkinson’s Disease, Spinal Cord Injury, and Strokes could, in the very near future, be eliminated through the simple culturing and implementation of stem cell therapy . These diseases are no small component of the myriad of conditions that plagues the human race, and yet, the end for these horrible maladies could very well be in sight. Man has always sought to end suffering, largely without success, until now. the promise that stem cell therapy holds could completely change our world for the better. Already, stem cell therapy is being used to treat leukemia, immune disorders, hodgkins and non-hodgkins lymphoma, anemia and a profusion of other ailments. As you all know, this is no small accomplishment. One day i believe that we may look at alzheimer's and diabetes and other major illnesses much like we look at polio today, as a treatable illness. Right now, our research with stem cells is providing us with new light into how we look at and model disease, our ability to understand why we get sick and even to develop new drugs. In 2008, a researcher from the New York Stem Cell Foundation Laborato...
Embryonic stem cells are derived from a four or five day old human embryo that is in the blastocyst phase of development (see figure 5). The embryo’s that are used for stem cell research, are extra’s that have been created in IVF clinics (in vitro fertilization), that are no longer needed. Embryonic stem cells are totipotent (cells with the potential to develop into any cells in the body). Scientists have discovered an alternative to embryonic stem cells, these cells ...
One of the most spoken of topic in the past four decades, are the advancements in genetic engineering. Stem cells were discovered in the mid-1800s and the subject of experimentation in the early 1900s, it’s only been in recent decades that they’ve truly caught the imagination of medical researchers and the public. Today, our understanding of these cells is expanding dramatically, and research has proliferated, as their potential is becoming clearer and clearer. Research into stem cells grew out of findings by Ernest A. McCulloch and James E. Till at the University of Toronto in the 1960s. “And the remarkable thing about the discovery itself is that we’re just starting to realize the potential of stem cells for medicine. In the 1960s, scientists recognized that Drs. Till and McCulloch’s discovery was important, but I don’t think anyone could have imagined that more than 45 years down the road their work would still be laying the basis for new ideas, new strategies, even new research institutes built around the concept of stem cells.” says Dr. Bob Phillips, Deputy Director of OICR and a former colleague of Till and McCulloch’s at the Ontario Cancer Institute.”[4]
Many patients in hospitals are waiting for transplants and many of them are dying because they are not receiving the needed organs. To solve this problem, scientists have been using embryonic stem cells to produce organs or tissues to repair or replace damaged ones (Human Cloning). Skin for burn victims, brain cells for the brain damaged, hearts, lungs, livers, and kidneys can all be produced. By combining the technology of stem cell research and human cloning, it will be possible to produce the needed tissues and organs for patients in desperate need of a transplant (Human Cloning). The waiting list for transplants will become a lot shorter and a lot less people will have to suffer and die just because they are in great need of a transplant....
...there are some risk factors in using stem cell for therapeutic approaches, hematopoietic stem cell therapy by bone marrow transplantation has already been proofed to be safe if donors’ background and screening, cell contamination, HLA matching and opportunistic or nosocomial infections during immunocompromised period were carefully monitored and controlled. Still, other types of stem cell therapies, despite of their good therapeutic efficacy, are remain in experimental stage and need more data to support and demonstrate the safety in clinical trials. More understanding of stem cell biology is also required in order to keep stem cell under controlled and avoid some complications that they might cause. So, to pave the way for successful stem cell therapy, research in this extent is needed to pursue to maximized therapeutic efficiency with highest safety in patients.