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Sickle cell research essay
Sickle cell anemia anatomy and physiology
Introduction to sickle cell anemia
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Sickle cell disease is an inherited disease where the red blood cells in the body are produced abnormally by bone marrow as crescent shaped red blood cells. Unlike normal red blood cells, sickle shaped cells are unable to deliver much oxygen to other parts of the body due to the abnormal hemoglobin. Sickle cell’s are stiff and sticky and tend to clump together between blood vessels that can cause pain, damage to the organs, and infections. If a child inherits this disease they can be healthy throughout their life or need special care. “In the United States, SCD is most common among blacks and Hispanics. SCD affects about 1 in 500 black births and about 1 in 36,000 Hispanic births in this country. SCD is also common among people with family from Africa, the Caribbean, Greece, India, Italy, Malta, Sardinia, Saudi Arabia, Turkey or South or Central America (March of Dimes)”.
Unfortunately this disease is passed down from the parent to the child genetically. “If both parents have sickle cell trait (each have one normal hemoglobin gene and one sickle cell gene), the child has a 50% chance of inheriting sickle cell trait (one normal gene, one sickle cell gene), 25% chance of inheriting sickle cell disease (two sickle cell genes), and 25% chance of not inheriting either the trait or the disease (two normal genes) (Harvey)”.
The child can obtain either the sickle cell trait or have a sickle cell disease. The sickle cell trait carries the abnormal gene of the person but they have normal hemoglobin without any symptoms. The patient can start developing symptoms related to the disease if they undergo any stress, infection, exhaustion, or hypoxia with mild anemia. Sickle cell disease occurs when normal hemoglobin has been replaced with sick...
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...minophen (NIH).” Additionally, Hydroxyurea (Droxia) is prescribed that diminishes the rate of recurrence of pain and acute chest-syndrome in patients.
Sickle cell disease can be very discomforting and painful for those who suffer with the symptoms that it brings interrupting the lives of patients. Even though sickle cell disease has no cure it can still be managed to where the patient can live a comfortable life.
Works Cited
"Sickle Cell Disease and Your Baby." Sickle Cell Disease and Your Baby. March of Dimes, Mar. 2013. Web. 20 Feb. 2014.
Simmon, Harvey. "Sickle Cell Disease." University of Maryland Medical Center. N.p., 14 Mar. 2013. Web. 06 Feb. 2014.
"Sickle Cell Research: Symptoms, Diagnosis, Treatment and Recent Developments | NIH MedlinePlus the Magazine." U.S National Library of Medicine. U.S. National Library of Medicine, 2011. Web. 06 Mar. 2014.
Epinephrine can be added to NE if needed to maintain acceptable BP, or substituted if necessary. Vasopressin (0.03 units/min) can be used as an adjunct to increase MAP,or to lower NE dose; it should not be used as a single agent. Dopamine can be used as an alternative to NE, but only in patients meeting criteria due to risk of arrhythmias; low dose dopamine not to be used for renal protection. Phenylephrine not recommended in most cases; can be utilized if NE leads to serious arrhythmias, CO is known to be high yet BP continues to be low, or as salvage therapy when MAP target is not achieved by other means. An arterial cath should be placed ASAP in patients who require vasopressors. Inotropes can be added to vasopressors or used alone, with a doubatmine trial of up to 20 mcg/kg/min as an option if myocardial dysfunction is suspected by elevated cardiac filling pressures and low CO, or if hypoperfusion is still evident although intravascular volume and MAP are at goal. Bicarbonate should not be used in patients with pH greater than or equal to
What is Sickle cell disease? Sickle cell affects a disease; that disease is called which affects the hemoglobin when the red blood cells that send oxygen through the body are killed off and weakened. Sickle cells can be found in every 1 and 1000 African Americans, it is affecting about 70,000 to 80,000 Americans in the United States. Sickle cell is a death threatening disease, and the severity of symptoms can vary from person to person (Sickle cell disease (SCD), 2015). Some people have light conditions, but others can have severe conditions, which, mean they could be hospitalized. Characteristics of this disease are caused by a minimum of low blood cells, which is called anemia.
During a short break of solitude from studying, I explored and came across that the environment in which most African Americans reside in has a high occurrence of malaria virus. The malaria virus disease is contagious and when it contaminates someone with sickle cell traits, it cannot survive on the external part of the human body so therefore the individual doesn’t develop the deadly malaria virus. While looking further into our class textbook on Human Genetics 11th Edition by Ricki Lewis, and this issue of sickle-cell among the African Americans, I
Sickle-cell anemia is a genetic disorder that makes your body produce red blood cells that are abnormal in shape. This disease is also widely known as hemoglobin SS disease. Unlike normal red blood cells, sickle cells are rigid and tenacious. Due to their shape and rigidness, they can block blood flow. In turn, this could cause organ damage to the body. Sickle cells are also fragile and die very easily due to the fact sickle cells have a lifespan of twenty days instead of the normal one hundred and twenty days for normal red blood cells.This causes the body to have a lower blood cell count, hence the name anemia in sickle cell anemia.
Sickle cell anemia is a hereditary disorder that mostly affects people of African ancestry, but also occurs in other ethnic groups, including people who are of Mediterranean and Middle Eastern descent. More than 70,000 Americans have sickle cell anemia. And about 2 million Americans - and one in 12 African Americans - have sickle cell trait (this means they carry one gene for the disease, but do not have the disease itself).
Sickle cell was first discovered by Dr. Ernest irons that was a hospital intern who look over a patients cell which seem to be different he called them “sickle cell shaped”. Sickle cell is know as a negro inherited diseases which is incorrect not only African Americans have this diseases. Many other races are effect by this diseases and regions all over the world such as India, Mediterranean countries, South American. In this case sickle disease work kind of like vaccination for malaria another diseases, this is the most common inherited disease in American. Anyone who has sickle trait and have a baby with someone who has the trait also can bring a baby into the world the world with SCD.
Sickle Cell Anemia is an inherited blood disorder that is extremely challenging to live with. Its symptoms are many, with the most prominent being severe pain that can become unbearable to the point where hospitalization is required. Because sickle cell is a genetic disorder, a person is born with it and it is usually permanent. Unfortunately, there are risks and complications associated with this disease. However there are various treatment options for a patient with sickle cell and also support to help people understand and cope with this challenging disease.
Sickle Cell is a disease that affects many people in the world today. It is the number one genetic disorder in the United States. Sickle Cell is deficient hemoglobin. Hemoglobin is what functions in providing oxygen to the cells in the body. The sickle shape comes from the atypical hemoglobin s molecules. Hemoglobin molecules are composed of two different parts called the alpha and beta. The beta subunit of the hemoglobin molecule has a mutation in gene, on chromosome 11 which produces the change in the red blood cell shape causing them to die and not reproduce accurately. The change in shape causes the red blood cells to get stuck in the blood vessels and block the effectiveness of oxygen transport causing pain and organ damage to the body. This disease does not have a cure and some common treatments are used to help patients live with the disease. Some treatment options are antibiotics (penicillin) to prevent infections, blood transfusions, folic acid that help produces new blood cells. These are just some of the current treatments for Sickle Cell.
Digoxin (Lanoxin) 250 mcg daily: In heart failure, increases contractility by inhibiting sodium/potassium ATPase pump in myocardial cells promoting calcium influx via sodium –calcium exchange pump ("Digoxin," 2015, p. 6).
The problem is that sickle cell anemia affects about 72,000 Americans in the United States. Sickle cell anemia is an inherited disease in which the body is unable to produce normal hemoglobin, an iron-containing protein. Abnormal hemoglobin can morph cells that can become lodged in narrow blood vessels, blocking oxygen from reaching organs and tissues. The effects of sickle cell anemia are bouts of extreme pain, infectious, fever, jaundice, stroke, slow growth, organ, and failure.
Sickle Cell Disease (SCD) is genetic disorder1, affecting 100,000 individuals in the United States2, resulting from a single amino acid substitution3, which causes abnormality to hemoglobin; a protein contained in red blood cells (RBCs) 4.
Oxygen was first admitted to the client with chest pain over 100 years ago (Metcalfe, 2011). Chest pain is a large bracket that can contain many different conditions, but for the purpose of this analysis it is focused manly upon a myocardial infarction. A myocardial infarction is mainly referred to as a heart attack, and occurs when one or more coronary arteries leading to the heart reduce or completely stop blood flow (Tuipulotu, 2013 ). Administering high concentrations of oxygen to patients with chest pain is now embedded in guidelines, protocols and care pathways, even with a lack of clear supporting evidence (Nicholson, 2004 ). High concentration of oxygen means that up to 60% is administered (Knott, 2012). More recent research has suggested that the use of oxygen in this scenario is unnecessary and can lead to unwanted side effects, especially in normoxic cardiac patients (Moradkham & Sinoway, 2010 ). The aim of this comparative analysis is to dismantle and understand both the benefits and risks of the commonly known practice of administration of oxygen to the client with chest pain. Through completing this analysis using recent and appropriate evidence a more improved practice can be given and understood.
B1.1 Where do you think you’ll find that the most villagers are dying from sickle-cell anemia? Explain.
Cornlanor has a contraindication to patients with acute decompensated heart failure, blood pressure less than 90/50 mmHg, sick sinus syndrome, sinoatrial block, or 3rd degree AV block, unless a functioning demand pacemaker is present, resting heart rate less than 60 bpm prior to treatment, severe hepatic impairment, pacemaker dependence (heart rate maintained exclusively by the pacemaker), concomitant use of strong cytochrome P450 3A4 (CYP3A4) inhibitors. Some common side effects include: Bradycardia, atrial fibrillation, bradyarryhthymias, hypertension, and visual brightness due to
Sickle cell anemia is an inherited blood disorder that affects the hemoglobin responsible for carrying oxygen throughout the body. (Centers for Disease Control and Prevention, 2010). This means that, unlike normal hemoglobin in which cells are smooth and round like the letter "O," that can pass through the vessels in our bodies with ease, sickle hemoglobin cells are rigid and form into the shape of a sickle, or the letter "C." The cells are also sticky and hence, cannot travel through small blood vessels. Consequently, they tend to cluster together and cause a blockage in the blood vessels and stop the movement of healthy oxygen-carrying blood.