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Sickle cell research essay
Sickle cell anemia anatomy and physiology
Introduction to sickle cell anemia
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Sickle cell disease is an inherited disease where the red blood cells in the body are produced abnormally by bone marrow as crescent shaped red blood cells. Unlike normal red blood cells, sickle shaped cells are unable to deliver much oxygen to other parts of the body due to the abnormal hemoglobin. Sickle cell’s are stiff and sticky and tend to clump together between blood vessels that can cause pain, damage to the organs, and infections. If a child inherits this disease they can be healthy throughout their life or need special care. “In the United States, SCD is most common among blacks and Hispanics. SCD affects about 1 in 500 black births and about 1 in 36,000 Hispanic births in this country. SCD is also common among people with family from Africa, the Caribbean, Greece, India, Italy, Malta, Sardinia, Saudi Arabia, Turkey or South or Central America (March of Dimes)”.
Unfortunately this disease is passed down from the parent to the child genetically. “If both parents have sickle cell trait (each have one normal hemoglobin gene and one sickle cell gene), the child has a 50% chance of inheriting sickle cell trait (one normal gene, one sickle cell gene), 25% chance of inheriting sickle cell disease (two sickle cell genes), and 25% chance of not inheriting either the trait or the disease (two normal genes) (Harvey)”.
The child can obtain either the sickle cell trait or have a sickle cell disease. The sickle cell trait carries the abnormal gene of the person but they have normal hemoglobin without any symptoms. The patient can start developing symptoms related to the disease if they undergo any stress, infection, exhaustion, or hypoxia with mild anemia. Sickle cell disease occurs when normal hemoglobin has been replaced with sick...
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...minophen (NIH).” Additionally, Hydroxyurea (Droxia) is prescribed that diminishes the rate of recurrence of pain and acute chest-syndrome in patients.
Sickle cell disease can be very discomforting and painful for those who suffer with the symptoms that it brings interrupting the lives of patients. Even though sickle cell disease has no cure it can still be managed to where the patient can live a comfortable life.
Works Cited
"Sickle Cell Disease and Your Baby." Sickle Cell Disease and Your Baby. March of Dimes, Mar. 2013. Web. 20 Feb. 2014.
Simmon, Harvey. "Sickle Cell Disease." University of Maryland Medical Center. N.p., 14 Mar. 2013. Web. 06 Feb. 2014.
"Sickle Cell Research: Symptoms, Diagnosis, Treatment and Recent Developments | NIH MedlinePlus the Magazine." U.S National Library of Medicine. U.S. National Library of Medicine, 2011. Web. 06 Mar. 2014.
Ally most likely has used ACE inhibitors and Beta blockers in the past and will be using them again.. The ACE inhibitors are vasodilators with the capability to widen the blood vessels allowing the blood pressure to lower down while improving the blood flow and decreasing the workload of the heart (WEbMD, 2017). Lisinopril is anangiotensin converting enzyme. This drug is used to treat high blood pressure, heart failure, helps to preent kidney failure --due to high blood pressure and diabetes. It is also used to prevent further damage and scarring of the muscles (Medicine Net, 2017). Another Ace inhibitor is Benazepril. It is used with hydrochlothiazide, at times, to treat high blood pressure. It can also be used to treat heart failure. Beta blockers are medications that lower your blood pressure.Beta blockerd work by blocking the effects of the hormone epinephrine. Two types of Beta blockers are Metoprolol relaxes blood vessels and slows down the heart rate and Nebivolol, which response to nerve impulses in certain parts of the body,like the heart (Mayo Clinic Staff). This helps to lower heart beats and decrease the blood pressure (Mayo Clinic Staff,
Epinephrine can be added to NE if needed to maintain acceptable BP, or substituted if necessary. Vasopressin (0.03 units/min) can be used as an adjunct to increase MAP,or to lower NE dose; it should not be used as a single agent. Dopamine can be used as an alternative to NE, but only in patients meeting criteria due to risk of arrhythmias; low dose dopamine not to be used for renal protection. Phenylephrine not recommended in most cases; can be utilized if NE leads to serious arrhythmias, CO is known to be high yet BP continues to be low, or as salvage therapy when MAP target is not achieved by other means. An arterial cath should be placed ASAP in patients who require vasopressors. Inotropes can be added to vasopressors or used alone, with a doubatmine trial of up to 20 mcg/kg/min as an option if myocardial dysfunction is suspected by elevated cardiac filling pressures and low CO, or if hypoperfusion is still evident although intravascular volume and MAP are at goal. Bicarbonate should not be used in patients with pH greater than or equal to
Cornlanor has a contraindication to patients with acute decompensated heart failure, blood pressure less than 90/50 mmHg, sick sinus syndrome, sinoatrial block, or 3rd degree AV block, unless a functioning demand pacemaker is present, resting heart rate less than 60 bpm prior to treatment, severe hepatic impairment, pacemaker dependence (heart rate maintained exclusively by the pacemaker), concomitant use of strong cytochrome P450 3A4 (CYP3A4) inhibitors. Some common side effects include: Bradycardia, atrial fibrillation, bradyarryhthymias, hypertension, and visual brightness due to
Digoxin (Lanoxin) 250 mcg daily: In heart failure, increases contractility by inhibiting sodium/potassium ATPase pump in myocardial cells promoting calcium influx via sodium –calcium exchange pump ("Digoxin," 2015, p. 6).
What is Sickle cell disease? Sickle cell affects a disease; that disease is called which affects the hemoglobin when the red blood cells that send oxygen through the body are killed off and weakened. Sickle cells can be found in every 1 and 1000 African Americans, it is affecting about 70,000 to 80,000 Americans in the United States. Sickle cell is a death threatening disease, and the severity of symptoms can vary from person to person (Sickle cell disease (SCD), 2015). Some people have light conditions, but others can have severe conditions, which, mean they could be hospitalized. Characteristics of this disease are caused by a minimum of low blood cells, which is called anemia.
During a short break of solitude from studying, I explored and came across that the environment in which most African Americans reside in has a high occurrence of malaria virus. The malaria virus disease is contagious and when it contaminates someone with sickle cell traits, it cannot survive on the external part of the human body so therefore the individual doesn’t develop the deadly malaria virus. While looking further into our class textbook on Human Genetics 11th Edition by Ricki Lewis, and this issue of sickle-cell among the African Americans, I
Sickle cell anemia is a hereditary disorder that mostly affects people of African ancestry, but also occurs in other ethnic groups, including people who are of Mediterranean and Middle Eastern descent. More than 70,000 Americans have sickle cell anemia. And about 2 million Americans - and one in 12 African Americans - have sickle cell trait (this means they carry one gene for the disease, but do not have the disease itself).
Sickle cell was first discovered by Dr. Ernest irons that was a hospital intern who look over a patients cell which seem to be different he called them “sickle cell shaped”. Sickle cell is know as a negro inherited diseases which is incorrect not only African Americans have this diseases. Many other races are effect by this diseases and regions all over the world such as India, Mediterranean countries, South American. In this case sickle disease work kind of like vaccination for malaria another diseases, this is the most common inherited disease in American. Anyone who has sickle trait and have a baby with someone who has the trait also can bring a baby into the world the world with SCD.
The mechanism of action for Alpha 1 Antagonists is to inhibit postsynaptic alpha-adrenergic receptors which causes vasodilation of vessels and in turn causes an overall decrease in blood pressure and peripheral resistance (Prazosin Lexicomp, 2015). The primary purpose of this drug or drug class is to treat hypertension but off label uses include use with regards to post-traumatic stress disorder (PTSD) related sleep disturbances as a sleep aid, as well as treatment of Raynaud’s disease (Prazosin Lexicomp, 2015). Prazosin (Minipress) is an oral medication and is highly protein binding at 97% of molecules that bind to receptors after dosing (Prazosin Lexicomp, 2015). This alpha 1 antagonist is metabolized in the liver and has immediate bioavailability at 60-86% of the drug left to bind after first pass metabolism in the liver (Prazosin Lexicomp, 2015). Prazosin (Minipress) has a half-life of 2-3 hours
Sickle Cell is a disease that affects many people in the world today. It is the number one genetic disorder in the United States. Sickle Cell is deficient hemoglobin. Hemoglobin is what functions in providing oxygen to the cells in the body. The sickle shape comes from the atypical hemoglobin s molecules. Hemoglobin molecules are composed of two different parts called the alpha and beta. The beta subunit of the hemoglobin molecule has a mutation in gene, on chromosome 11 which produces the change in the red blood cell shape causing them to die and not reproduce accurately. The change in shape causes the red blood cells to get stuck in the blood vessels and block the effectiveness of oxygen transport causing pain and organ damage to the body. This disease does not have a cure and some common treatments are used to help patients live with the disease. Some treatment options are antibiotics (penicillin) to prevent infections, blood transfusions, folic acid that help produces new blood cells. These are just some of the current treatments for Sickle Cell.
For emphysema – Fluticasone propionate 250 mcg/salmeterol 50 mcg. Fluticasone is a steroid that prevents the release of substance in the body causing inflammation and salmeterol is a bronchodilator according to information obtained from the Mayo Clinic (2016). The effect pursued with this medication is muscle relaxation in the airways improving breathing. Dosage: Two inhalations a day (inhalation powder); one in the morning and one in the evening. Medication has been taken for 12 years and she stated it is working properly with no adverse effects.
Oxygen was first admitted to the client with chest pain over 100 years ago (Metcalfe, 2011). Chest pain is a large bracket that can contain many different conditions, but for the purpose of this analysis it is focused manly upon a myocardial infarction. A myocardial infarction is mainly referred to as a heart attack, and occurs when one or more coronary arteries leading to the heart reduce or completely stop blood flow (Tuipulotu, 2013 ). Administering high concentrations of oxygen to patients with chest pain is now embedded in guidelines, protocols and care pathways, even with a lack of clear supporting evidence (Nicholson, 2004 ). High concentration of oxygen means that up to 60% is administered (Knott, 2012). More recent research has suggested that the use of oxygen in this scenario is unnecessary and can lead to unwanted side effects, especially in normoxic cardiac patients (Moradkham & Sinoway, 2010 ). The aim of this comparative analysis is to dismantle and understand both the benefits and risks of the commonly known practice of administration of oxygen to the client with chest pain. Through completing this analysis using recent and appropriate evidence a more improved practice can be given and understood.
Sickle Cell Disease (SCD) is genetic disorder1, affecting 100,000 individuals in the United States2, resulting from a single amino acid substitution3, which causes abnormality to hemoglobin; a protein contained in red blood cells (RBCs) 4.
B1.1 Where do you think you’ll find that the most villagers are dying from sickle-cell anemia? Explain.
According to Hassel (2010), approximately 100,000 Americans have the disease. What then are the factors the increases one’s chances of inheriting such a disease? Simply put, what are the risk factors? The risk of inheriting sickle cell disease comes down to two factors: genetics and ethnic background. For a baby to be born with sickle cell, both parents must carry a sickle cell gene. For instance, if one parent has sickle cell disease (two sickle cell genes) and the other parent has sickle cell trait (one normal gene, one sickle cell gene), the child has a 50% chance of inheriting sickle cell trait and a 50% chance of inheriting sickle cell disease. If one parent has sickle cell disease and the other parent has two normal hemoglobin genes, the child has a 100% chance of inheriting sickle cell trait, but not the disease. If both parents have sickle cell disease, the child has a 100% chance of inheriting the disease. In essence, sickle cell disease is inherited and people at risk for inheriting the gene for sickle cell descend from people who are or were originally from Africa, parts of India and the Mediterranean. The sickle cell gene also occurs in people from South and Central America, the Caribbean, and the Middle East. In the United States, most people with sickle cell disease are of African ancestry or identify themselves as black. To buttress this point, Bennett (2006) argues that about 1 in 13 African American babies is born with sickle cell trait and about 1 in every 365 black children is born with sickle cell disease. There are also many people with this disease who come from Hispanic, southern European, Middle Eastern, or Asian backgrounds. There are no standard treatments that cure sickle cell disease especially when the risk factors are related to genetics and ethnic background because they are non-modifiable (permanent and cannot be