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Case history of atrial fibrillation
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To slow the rate at which blood clots in a patient, a doctor may or may not administer a course of anticoagulant therapy. Anticoagulant therapy is a course of drugs taken by the patient, who might have one or more cardiovascular diseases, to prevent clots from forming. The most common use for anticoagulants is atrial fibrillation, an irregular heart rhythm [7]. They’re also administered for patients who have mechanical heart valves or patients who have blood clots [7]. There are many types of anticoagulants used, most commonly administered was Warfarin (Coumadin) [5]. However, due to recent advances in medicine many new anticoagulants have surfaced such as Apixaban, Dabigatran, Edoxaban, Rivaroxaban and many others [4]. Practitioners have more …show more content…
Which in turn leads to a decrease of this gamma carboxy-glutamic acid which leads to a suppression of clotting factors [3]. They are referred to as blood thinners because blood that can’t clot as easily is commonly referred to as thin. When administering these drugs, the practitioner must consider the patient’s underlying disease and the risks and benefits of the medication. There are many negative side effects of anticoagulation therapy and one major side effect is bleeding. For Coumadin, research has shown every patient who is on this medication there is a 1% or 2% chance of bleeding per year. Some patients may be on these medications for years or decades, thus greatly increasing the risk of bleeding [6]. The risk of bleeding is considered the biggest concern with taking blood thinners because the body might not be able to clot enough when it needs to, causing unwanted or frequent bleeding [6]. Also, patients on blood thinners might be taking other medications. One potential risk is the adverse interactions blood thinners might have with other drugs taken by the
In septic patients, increased levels of PAI-1 inhibit plasminogen activator (t-PA), which converts plasminogen to plasmin. Release of fibrin inhibits fibrinolysis by activation of thrombin-activatable fibrinolysis inhibitor (TAFI). In addition, the release of PAF causes platelet aggregation. This combination of inhibition of fibrinolysis, fibrin strand production and platelet aggregation contribute to a state of coagulopathy. This can lead to microcirculatory dysfunction with isolated or multiple organ dysfunction and cell death. Mr Hertz’s coagulation profile showed a fibrinogen level of 5.6 g/L, indicating that coagulopathies were underway in his system.
27-Ussia GP, Scarabelli M, Mulè M, et al. Dual antiplatelet therapy versus aspirin alone in patients undergoing transcatheter aortic valve implantation.Am J Cardiol 2011;108:1772–6.
Ischemic Stroke is caused due to a blood clot in an area of the brain, leading to loss of neural function if last for more than 24 hours. In the United States, ischemic stroke affects 2.7% of men and 2.5% of women of age range 18 years and older. In addition, it has reported that annually about 610,000 and 185,000 of new strokes and recurrent strokes cases occur in US1. Moreover, it has reported that patients who have suffered from a stroke have more chances of recurrent stroke, Myocardial infarction, and death from vascular causes2. One of the risk factor of ischemic stroke is formation of plaque in the blood vessels causing blood clot3. Several randomized trials have also reported that antiplatelet medications are efficient in preventing recurrences of stroke in patients who had an incident of ischemic stroke. Antiplatelet medications for preventing recurrences of stroke are aspirin, combination of aspirin and extended-release dipyridamole, and clopidogrel alone4. It ha...
...n also occur. This can occur due to increased serotonin at the synaptic levels which causes inhibition of the release of dopamine through specific presynaptic serotonin receptor subtypes. Another typical side-effect includes bleeding such as brusing, epistaxis, and gastrointestinal bleeding. SSRIs inhibit platelet functions and this could lengthen the time and risk of bleeding. When serotonin receptors are hyperstimulated, a condition called serotonin syndrome can occur. This syndrome brings about nausea, diarrhea, restlessness, delirium, extreme agitation, seizure, hyperreflexia, and many other symptoms. This syndrome can occur if SSRIs are taken together with a monoamine oxidase inhibitor (a member of a different class of antidepressants).
(14) Connolly SJ, Ezekowitz MD, Yusuf S, Eikelboom J, Oldgren J, Parekh A, Pogue J, Reilly PA, Themeles E, Varrone J, Wang S, Alings M, Xavier D, Zhu J, Diaz R, Lewis BS, Darius H, Diener HC, Joyner CD.. (2009). Dabigatran versus warfarin in patients with atrial fibrillation.. New England Journal Of Medicine. 361 (12), 1139-51.
If this happens, their immune system will develop antibodies against factor VIII. These antibodies will inhibit the ability of the factor to work in the clotting process. The higher the antibody or inhibitor level, the more factor VIII replacement therapy it takes to overcome the inhibition and produce clotting. This can complicate the treatment of a bleed. The good news is that there are different types of therapies available to successfully treat most individuals who develop inhibitors.
“If you’re at high risk for ischemic stroke, your doctor may prescribe drugs that reduce clots by interfering with the aggregation (clumping together) of blood cells called platelets” (Prevention of a Stroke 4). Your doctor would prescribe a specific type of medication called antiplatelet drugs. Anticoagulants (blood thinners), like antiplatelets, interfere with the formation of blood clots, but they work at a different stage in the clotting process- preventing the formation of fibrin, a protein that plays a role in blood clotting. “Statin medications lower blood cholesterol levels by blocking the activity of an enzyme crucial for the production of cholesterol by the liver. These medications also help stabilize plaques- the fatty deposits in arteries that can rupture and trigger the formation of a blood clot that can lead to a stroke” (Prevention of a Stroke 18). Statins are used to lower blood cholesterol levels and reduce inflammation in the artery walls. The medications your physician prescribes will depend on how great your risk of a stroke is as well as your risk of side effects from these
Before WWI, the practice of medicine was far from how it has developed into today. The practice was not advanced, and therefore, had few concrete methods. However, with the beginning of the First World War, there was a great push to improve these methods. Although the war caused much illness and death, it also catalyzed many improvements such as blood transfusions, x-rays, vaccines, and sanitation.
... you should take baby aspirin (81 mg). The earlier a patient takes preventative measures the less a patient has to worry about taking other medication such Warfarin which have many adverse side effects such as excessive bleeding. Patients need to continuously check legs for any signs and symptoms of DVT.
Studies have shown that birth control can cause an increase of blood clots (also known as venous thromboembolism, or VTE), especially the newer forms of birth control (oral contraceptive) such as the the NuvaRing. British Medical Journal cited in the Vanity Fair article concluded that the risk of getting a blood clot is 6.5 times greater when using some sort of contraceptive. Without birth control about 2.1 women out of 10,000 will get a blood clot each year. When women use oral contraceptive the number rises to 6.2 out of 10,000. When using the NuvaRing the number jumps to 7.75 out of 10,000. Even though there is a risk for blood clots, the study did not consider pertinent external variables including smoking, obesity, and family history (Gueren, 2013).
There has been a dramatic rise in the rate of caesarean section (CS) in the last two decade making it the most commonly performed procedure worldwide. 1Surveys (2, 3) have indicated that 3-5% of total red cells transfusion is related to obstetrics with higher rate in CS patients compared to those having vaginal delivery (1-7% versus 1%) (4, 5).
Much of the blood needed for transfusions in Mississippi is shipped from nearby states as people in Mississippi do not usually donate enough to supply the demand for blood with in the state. The donated blood obviously goes to a multitude of patients in Mississippi; from people in car crashes, to cancer patients, to people sickle-cell disease, and many more.
Atherosclerosis is a disease that occurs when arteries become blocked, inflamed, or hardened. As a result of this, blood cannot easily pass through the artery, and blood pressure increases. Many people suffer from atherosclerosis as they age, but young people can be affected by atherosclerosis also. There are many preventative steps that can be taken to decrease the risk of atherosclerosis; however, if atherosclerosis does develop in the arteries, medications can be given to help the individual receive adequate blood flow to important tissues. Atherosclerosis is a very serious condition that requires medical attention and a change in life style because it is a precursor to many dangerous and potentially fatal diseases.
...thesis a family of compound called menaquinones (vitaminK_2). People who do not eat them regularly are likely to be deficient in their intake of vitamin K. Well, it can be prevented by consuming a proper diet. Some people may take easy on this matter and do not care much about their healthy lifestyle, so this may cause to serious blood clotting problem. Besides that, low levels of vitamin K may increase the risk of uncontrolled bleeding and a health care provider might suggest the patients to take vitamin K supplements (Tremblay, n.d.). Hence, vitamin K is very important in helping the blot clot to prevent excessive bleeding.
Heart patients and those who take coumadin or other blood thinners need to check with their physicians because tea has vitamin K, which can interfere with the effectiveness of the medication.