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Primary prevention of tuberculosis disease
Introduction to mycobacterium tuberculosis
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What is Tuberculosis, and how serious is this problem?
TB, or Tuberculosis, is a chronic or acute contagious disease caused by a bacterial infection. TB is the leading cause of death from a single infectious disease, accounting for over a quarter of avoidable deaths among adults. It can affect several organs of the human body, including the brain, the kidneys and the bones, but it predominately manifests itself in the lungs where it is called "Pulmonary Tuberculosis".
According to the WHO, TB infection is currently spreading at the rate of one person per second. It kills more young people and adults than any other infectious disease and is the world's biggest killer of women. Researchers have calculated that 8-10 million people catch the disease every year, with three million dying from it. It causes more deaths worldwide than AIDS and Malaria combined. The WHO predicts that by 2020 nearly one billion people will be newly infected with TB, of them 70m will die. TB black spots include Eastern Europe with 250,000 cases a year, South East Asia; three million cases a year and sub-Saharan Africa with two million cases a year.
Tuberculosis, a sometimes crippling and deadly disease, is on the rise and is revisiting both the developed and developing world. The global epidemic is growing and becoming more dangerous. The breakdown in health services, the spread of HIV/AIDS and the emergence of multi drug-resistant TB are contributing to the worsening impact of this disease. Overall, one-third of the world's population is currently infected with the TB bacillus.
How TB Spreads:
TB is a contagious disease. Like the common cold, it spreads through the air. A person acquires a tuberculosis infection by inhaling tiny droplets of moisture contaminated with the Mycobacterium Tuberculosis bacteria. The source of these droplets is frequently from infectious individuals who expel thousands of water droplets into the air every time they cough, sneeze, talk or spit. A person needs only to inhale a small number of these to be infected. The most common places for becoming infected with TB are right in your own home, or your workplace. Often the source of the infection is unknown since the initial infection may have occurred several years ago.
Left untreated, each person with active TB will infect on average between 10 and 15 people every year and these people are mostly likely to be family members, friends, coworkers, and those who share the same breathing space.
Paul Farmer was born in Massachusetts in 1959, went to Harvard Medical School, became a doctor, and ended up living and working in Haiti. He co-founded an organization in 1987 called Partners in Health (PIH). The philosophy behind the organization is that everyone, no matter who or where has a right to health care. Paul Farmer and PIH have already made amazing progress in Haiti, Peru, and several other countries, helping people get the care they need. PIH’s website lists a detailed history of they and Farmer’s work in Haiti. When Paul Farmer first came to Cange, Haiti as a medical student in 1983, the place was in shambles. In 1956, a dam was built on the Artibonite River, flooding the village and forcing the residents to move up into the hills. Many of these displaced villagers were still essentially homeless after nearly thirty years, and had little access to quality health care. With the founding of the Zanmi Lasante clinic later in 1983, Farmer and his friend Ophelia Dahl set the people of Cange on the road to recovery by providing access to doctors, medicine, and emergency care, all completely free. (“Partners”) One of Farmer’s focuses was on tuberculosis (TB) and has had much success on this front. Through new studies and methods such as active case finding and community health workers, as well as his work with multidrug-resistant TB, Paul Farmer has revolutionized treatment of tuberculosis in Haiti and around the world.
The outburst spread of diseases in a population causes people to panic and become hopeless. The main reason diseases spread is due to unsanitary living styles. Also when a disease first begins, it is really hard to find a cure right away. A very deadly, infectious disease known as Typhus spread during the Holocaust. Typhus is caused by rickettsia and is spread by lice and flees.
My disease is Streptococcal pneumonia or pneumonia is caused by the pathogen Streptococcus pneumoniae. Streptococcus pneumoniae is present in human’s normal flora, which normally doesn’t cause any problems or diseases. Sometimes though when the numbers get too low it can cause diseases or upper respiratory tract problems or infections (Todar, 2008-2012). Pneumonia caused by this pathogen has four stages. The first one is where the lungs fill with fluid. The second stage causes neutrophils and red blood cells to come to the area which are attracted by the pathogen. The third stage has the neutrophils stuffed into the alveoli in the lungs causing little bacteria to be left over. The fourth stage of this disease the remaining residue in the lungs are take out by the macrophages. Aside from these steps pneumonia follows, if the disease should persist further, it can get into the blood causing a systemic reaction resulting in the whole body being affected (Ballough). Some signs and symptoms of this disease are, “fever, malaise, cough, pleuritic chest pain, purulent or blood-tinged sputum” (Henry, 2013). Streptococcal pneumonia is spread through person-to-person contact through aerosol droplets affecting the respiratory tract causing it to get into the human body (Henry, 2013).
the bubonic plague. Like the bubonic plague did in the Middle Ages, AIDS is spreading at an alarming rate. In 1994 seventeen million people around the world were
Signs and Symptoms of Active Tuberculosis Mycobacterium tuberculosis (MT) is a slender, rod-shaped, aerobic bacillus which causes tuberculosis. Tuberculosis (TB) is an airborn infection which is transmitted via inhaling droplet nuclei circulating in the air. These droplets are expelled from the respiratory secretion of people who have active TB through coughing, sneezing, and talking (Porth, 2011). Some bacilli stay in the upper airway and are swept out by mucus-secreting goblet cells and cilia on the surface of the airway.
On average there are around 300-500 million people who become infected with malaria every year, with most of the cases occurring in sub-Saharan Africa. (in text refernce). Other areas which are affected by malaria include- Asia, Latin America and some parts of Europe.
Every year millions of people die. People die either from natural causes or from another source like murder. Cancer and AIDS are the number one diseases leading to death in the 21st century. (Jueneman 1) However, they have not always been the leading diseases. Around as early as 542 AD, a deadly disease broke out in Constaniople and quickly spread around the world within a few hundred years. This disease in considered the worst natural disaster in history. The Bubonic plague, also known as the Black Death, is historically the disease that has caused the most deaths and caused China, Europe, and India to shortly stop trade altogether.
According to the World Health Organization, 1.5 million people died from TB in 2013. (WHO, 2014). CDC report that “In the United States, 536 people died from tuberculosis in 2011” (CDC, 2013).
After the plague had past it kill one in five people. It had killed over 35 million people in China. The plague had also killed 20 million people in Europe almost one third of the population. (eyewitnesstohistory) They think that the plague killed up to 10,000 people a day. Which in the end had killed over 75 million people altogether.
The spread of the bubonic plague had killed many people from many different countries because the plague spread easily through merchants. In Europe, one third of the population, about 25 million, people died from the Black Death. The Black Death also spread to Central Asia, North Africa, and the Byzantine Empire. In China, about 35 million people died during the Black Death. The population dropped from about 125 million to about 90 million near the end of the 1300s. This shows how fatal the disease was and how fast and easily it
Tuberculosis is transmitted by inhalation of aerosols containing the tubercle bacilli. The required inoculum size for infection is usually high, but easily occurs with exposure to a patient who is currently infected. The products of dried aerosols, droplet nuclei, are particularly infectious because they remain in the air for an extended time, and upon inhalation easily move to the alveoli. The severe damage related to infection is caused by the reaction of the host. The tuberculosis infection has two phases, primary and secondary.
It can be spread by direct contact with an infected person after prolonged face-to-face contact or through the air by droplets that escape the infected person when the person coughs, sneezes or talks.
Wines, M. 2007. Virulent TB in South Africa may imperil millions. New York Time. January 8. Accessed online at http://www.nytimes.com/2007/01/28/world/africa/28tuberculosis.html?pagewanted=all
Researchers have also identified a list of other factors associated with TB transmission such as environmental, organism and host factors, but these unfortunately, are outside the scope of the present paper. 16
Tuberculosis has plagued mankind for a long time. This disease, which was previously believed to be eradicated, has once again shown up and begun attacking the lives of many humans. Tuberculosis infects a third of the population and kills a fraction of them. Many approaches have been used including different varieties of infection control, bodily defenses, and treatments to try to protect humans from tuberculosis. The best way to prevent tuberculosis infections is to contain the source of tuberculosis. The most common source of tuberculosis infection is from infected humans. By diagnosing, containing, and treating people with latent tuberculosis before they get active, contagious tuberculosis, tuberculosis can be quickly contained. Once someone has been diagnosed with TB, they should be placed under isolation.