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Innate immunity is quizlet
Innate immunity is quizlet
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The innate immune system is given to you at birth and always has microbes ready to fight (Joanne M. Willey, 2014). This system is very fast to detect and attempt to eliminate any invading cells. It reacts by triggering Toll-like receptors (TLRs) who then fasten to pathogen-associated molecular patterns (PAMPs) (Joanne M. Willey, 2014). The first line of defense in the innate immune system contains the skin and mucous membranes, along with normal microbiota (Joanne M. Willey, 2014). The second line of defense of the “early-warning” system consists of natural killer cells, phagocytes, eosinophils, dendritic cells, macrophages, inflammation, fever, and antimicrobial substances (Joanne M. Willey, 2014). Although a powerful system, it cannot take …show more content…
Willey, 2014). The adaptive immunity contains Naïve B cells which turn into antibodies, and naïve T cell which later turn into effector T cells (Joanne M. Willey, 2014). Adaptive immunity has memory (Joanne M. Willey, 2014). This means that the adaptive immunity is a prompt and stronger immune reaction to the same microbe later on if it comes back (Joanne M. Willey, 2014). As a part of this third line of defense, it involves antibodies, along with lymphocytes called T cells and B cells (Joanne M. Willey, 2014). They change to handle a particular microbe (Joanne M. Willey, 2014). Foreign substances that start up an immune response are called antigens (Joanne M. Willey, 2014). The presence of external antigens causes B and T cells to replicate and make more proteins that function to protect the host (Joanne M. Willey, 2014). The B cell is most important because it produces and secretes antibodies. Antibodies bind to antigens and inactivate them to help kill them (Joanne M. Willey, …show more content…
These cells are lymphocytes which means they are involved in specific immune responses to foreign matter; specifically in adaptive immunity (Joanne M. Willey, 2014). The hematopoietic stem cell branches off to the lymphoid progenitor (Joanne M. Willey, 2014) . That splits into lymphoblasts which make the agranulocytes, T and B cells (Joanne M. Willey, 2014). T cells assist B cells to rid foreign cells, and turn into memory cells (Joanne M. Willey, 2014). The T-Helper cell dictates growth and variation factors (Joanne M. Willey, 2014). This decides whether you will have a strong or weak immune system (Joanne M. Willey, 2014). The cytotoxic cells are accountable for lytic enzymes and proteins (Joanne M. Willey, 2014). They kill or change injected cells (Joanne M. Willey, 2014). The suppressor cells are also known as 911 and relay a rapid response to reinfection with the same cell (Joanne M. Willey,
Sepsis is defined as an exaggerated, overwhelming and uncontrolled systemic inflammatory response to an initially localised infection or tissue injury, which may lead to severe sepsis and septic shock if left untreated (Daniels, 2009; Robson & Daniels, 2013; Dellinger et al, 2013; Perman, Goyal & Gaieski, 2012; Vanzant & Schmelzer, 2011). Septic shock can be classified by acute circulatory failure as a result of massive vasodilation, increased capillary permeability and decreased vascular resistance in the body, causing refractory hypotension despite adequate fluid resuscitation. This leads to irreversible tissue ischaemia, end organ failure and ultimately, death (McClelland & Moxon, 2014; Sagy, Al-Qaqaa & Kim, 2013, Dellinger et al, 2013).
The B cells, T cells, Macrophage, and Antibodies are all a very large part of the immune system. There are two types of T cells, killer and helper T cells. Killer T cells find and destroy cells infected with bacteria, and helper T cells control the activity of other cells in the immune system. Then, B cells are considered the “clean up crew,” attacking any bacteria or viruses the T cell left behind. They also make antibodies, which are essential for trapping invading viruses and
Stem cells are the building blocks of the human body. Embryos consist of unspecialized stem cells that transform into the various specialized cells in the body such as cardiac, muscle or bone cells. Fetuses also have stem cells. However, the stem cells are divided into types like muscle, bone or nerves and don't perform a specialized function. Surprisingly, adult bodies also contain stem cells. In adults, stem cells are undifferentiated but limited to specific tissue type. When needed, the stem cells transform into the cells needed for repair and maintenance. The most common source of adult stem cells is bone marrow. Researchers also acquire stem cells from umbilical cords. Without stem cells, embryos could not develop into fetuses and adult
The body is composed of cells, which form the basic unit of life. Unique cells found in the body are the stem cells. These cells are biological cells that are not specialized for particular functioning in organisms. They can be distinguished since they have the ability to differentiate or divide into multiple body cells, and their ability to replicate self. They are unique in the way they can renew themselves by undergoing cell division when inactive for a long period. It is also possible to induce stem cells to organs or tissue cells under some conditions. When the cells divide, they replenish the cells in a living organism. They serve as an internal system that repairs and replaces the tissues that are worn out.1 Dividing cells may remain as stem cells or become specialized in their functions, for instance red blood cells, brain or muscle cells.
As stated by John Pearson, once a stem cell is gained through one of these processes it is reproduced in a lab and formed into what is known as a “cell line”. Each cell line was started from a differ...
The job of the immune system is to keep “foreign” invaders out of the body, or if one gets in, to seek it out and kill it. These foreign invaders are called pathogens, which are tiny organisms that can cause an infection in the body. Pathogens can be bacteria, parasites, and fungi (http://www.niaid.nih.gov/topics/immuneSystem/pages/whatisimmunesystem.aspx).
Many great historical figures of the scientific community have written on the subject of the same perplexing disease over the centuries (Angus, van der Poll, Finfer, Vincent 2013). Sepsis has been given many names, origins, and etiologies. In the 4th century, Hippocrates declared the disease the cause of organic decomposition, wound festering, and swamp gas (Angus et al. 2013). During the 19th century, Louis Pasteur theorized the disease was the outcome of a pathogenic microorganism in the bloodstream, which resulted in a body-wide infection (Angus et al. 2013). In the 21st century, the medical community made a breakthrough with the discovery of the disease’s link to the inflammatory response system and devised a plan of action to combat the high mortality rates among those infected (Angus et al. 2013). According to Hotchkiss, Monneret, & Payen (2013) the effects of sepsis are well documented, while the molecular processes it utilizes are still being explored; however, new studies are helping to expand our understanding of the centuries old disease.
The structure and function of our immune systems is a great help for our body to keep all of us healthy. Our immune system has a specific structure that it should maintain. There are also organs that play a major part for the health of our immune system. These organs are called lymphoid organs because of the lymphocytes that inhabit that area. (white blood cells) Bone marrow is also one of the key elements for the immune system, this is where all of our blood cells are being made along with the white blood cells. With the help of the bone marrow, white blood cells are constantly traveling throughout our bodies using the blood cells for help. Another structure that is important for our immune system is lymphoid tissue. Lymphoid tissue acts as a gateway into our bodies that help to prevent incoming germs.
Seattle Education Project. (2013, November). STEP: The Immune System - An Overview, [Online]. Available: http://www.thebody.com/step/immune.html [11/12/14].
When a cell in our body has become infected or has become cancerous it’s surface changes. This is how the immune system can tell good cells from bad ones (the markings on the surface.) Once a bad cell has been recognized our bodies sends cells to destroy the damaged cell and prevent the spread of whatever caused the damage in the first place. The next step our body takes is to have the affected cells start to produce interferons and other helpful substances. These help to fight off unwanted organisms, and also to warn other cells of the invaders and prepare them to resist them therefore preventing the spread of disease.
The immune system is a highly evolved and complex defence system, armed against millions of potential pathogens that may cause infection at any point. Pattern recognition receptors, known as PRRs, are displayed by the cells of the innate immune system, such as macrophages and dendritic cells, and recognise pathogen associated molecular patterns or PAMPs. PAMPs are evolutionary conserved structural similarities found in many pathogens but not in the host’s own cells allowing the innate immune system to distinguish between self and non self and to react to the pathogens immediately (Mogensen, 2009). Antigen recognition receptors are used by the lymphocytes of the adaptive immune system to provide a highly specific and targeted response to a precise epitope of an antigen. However as a single lymphocyte carries only a single type of antigen recognition receptor that recognises one type of antigen the chance of a pathogen of finding a lymphocyte with a given specificity is low. Therefore the adaptive immune response takes time to mobilise hence the innate immune system is essential to keep the infection
Inflammation which is part of the innate immune system is a process by which the body reacts to injury protecting it from infection and foreign substances with the help of the body’s white blood cells “Inflammation can be defined as the body’s local vascular and cellular response to injury caused by factors that invade and injure the body from the outside (exogenous factors) or factors within the body that result in cellular or tissue injury (endogenous) factors” (Battle, 2009, P 238). Factors such as bacteria, viruses, burns, frostbite, chemical irritants, immune reactions and physical injury are examples of factors that can cause inflammation through different mechanisms. It is a protective mechanism with rapid response that neutralizes or destroys agents that causes injury and creates a barrier that limit the injury and prevents its spread to normal tissues (Battle, 2009). Also, it has elements that removes debris and heals the wound generated by the injury. It can be divided into acute and chronic inflammation.
Adaptive immune system happens much quicker to the presence of an “infection creating potent mechanisms for neutralizing or eliminating the microbes. There are two types of adaptive immune responses: humeral immunity, mediated by antibodies produced by B lymphocytes, and cell-mediated immunity, mediated by T lymphocytes.”
For an extended period, chemotherapy, surgery, and radiation therapy have been the main pillars of cancer treatment. Over the last decade, drugs that targets cancer cells by homing in on certain molecular changes have emerged that are aimed at treatment of various cancer cells. Moreover, immunotherapy has emerged for the treatment of different types of cancers. Immunotherapy is an innovative treatment method that strengthens the human immune system to conquer cancer and other incapacitating diseases (June 18). One of the immunotherapy approaches includes the engineering of patients ‘immune cells to identify and attack their tumors. Even if this approach known as adoptive cell transfer (ACT), has been limited to small scientific
People incorporate inflammation whenever there is a presence of pain, swelling, or redness to a person’s body part. Inflammation gives a sign that there is an infection or tissue damage. Inflammations is part of human’s defensive response whenever their body is injured or invaded by small organism like germs and viruses. This response was then distinguished as a branch of immune system. Scientists discovered that the inflammatory response is due to the molecular structure known as the inflammasomes. Inflammasomes are molecular structure that have white blood cells, which contains macrophages; macrophages spits out protein that immobilize and weaken the microbes (Mehal 2015). Based on the study, inflammasomes can be found in every part of our body. The most common inflammasome that can be found in our body is NLRP3. For each inflammasome to be active, it has to be triggered by invaders. The concern about inflammasome is it contributes a wide range of diseases.