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Literature review on Polio
History of vaccines
Essay on the history of polio
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Recommended: Literature review on Polio
“There is hope in dreams, imagination and in courage of these who wish to make dreams a reality.” Jonas Salk the creator of the Polio Vaccine once said. His imagination led to this pioneer in medical science to reducing 350,000 inevitable cases of the Polio virus in 1952 to just 223 cases in 2012. This Extraordinary feat of immense proportion cannot go unnoticed by medical science. This form of distributing medicine may damage the epidermis but it revolutionized and contributed so much to modern medicine. Like the economic and medical advancements like using vaccines to combat deadly pathogens. However controversy struck when traces of mercury “a highly toxic substance” was found in vaccines in the 20th century. Also, side effects are very present when it comes to vaccines. But controversy is unnecessary because of significant decrease of some diseases. …show more content…
The more correct term is poliomyelitis the name of the singular pathogen cell. Standing at 30 nanometers tall and wide, this is one of the smallest pathogens with a virus that is fatal and common. You get infected by letting the pathogen getting inside a carless wound or cut on the epidermis. Most patients are adolescents, children, or early teens. One of the first epidemics was in 1907 with 2,500 cases in New York. The first time the bacteria was isolated was by Erin Popper a biologist in 1909. Jonas Salk was born in October 28, 1914 in New York City. When Salk was an adolescent he was not interested in medical or science as a whole. He was more interested in becoming an attorney or prosecutor but his mother disapproved of his career choices. Jonas said “Science bored me until high school.” From 1934-1939 he attended New York University School of medicine. This led to him winning prestigious honors like the Medal of Freedom. He worked on the vaccine from 1948-1950 with
Sabin, on the other hand, began researching during medical school, and similarly served the interests of the United States Army during the Second World War.
Moreover polio is a deadly disease that is caused by a highly contagious virus entering the nervous system in the brain or spinal cord causing temporary or permanent paralysis. There are three
Polio: An American Story describes a struggle to find a vaccine on polio through several researchers’ lives, and over the course of many years. The second thesis is the struggle between Salk and Sabin, two bitter rivals who had their own vaccine that they believed would cure polio. The author David M. Oshinsky, is describing how difficult it was to find the cure to a horrifying disease, which lasted from the Great Depression until the 1960’s. Oshinsky then writes about how foundations formed as fundraisers, to support polio research. Lastly, the author demonstrates how researchers were forced to back track on multiple occasions, to learn more about polio.
As a researcher, his main goal was to find a cure for cancer. The first discovery was made in 1952, in the developing field of virology. Virology is the study of viruses and how they behave. To develop the vaccines for the viruses, researchers infected the HeLa cells with many types of infections, such as measles, mumps, and the infamous poliomyelitis virus, also known as Polio. According to the Centers for Disease Control and Prevention (CDC), whose mission is to save lives and protect people’s health, Polio is a "crippling and potentially deadly infectious disease caused by a virus that spreads from person to person, invading the brain and spinal cord and causing paralysis" (Freeman).
Disease and parasitism play a pervasive role in all life. Many of these diseases start with microparasites, which are characterized by their ability to reproduce directly within an individual host. They are also characterized by their small size, short duration of infection, and the production of an immune response in infected and recovered individuals. Microparasites which damage hosts in the course of their association are recognized as pathogens. The level of the interaction and the extent of the resultant damage depends on both the virulence of the pathogen, as well as the host defenses. If the pathogen can overcome the host defenses, the host will be damaged and may not survive. If on the other hand the host defenses overcome the pathogen, the microparasite may fail to establish itself within the host and die.
Poliomyelitis was the term used by doctors to describe the condition in which the gray (polios) anterior matter of the spinal chord (myelos) was inflamed (-itis). Until a cure was discovered, no one had the slightest idea where "polio" had come from or why it paralyzed so many children. People learned later that, oddly enough, it was the improved sanitary conditions which caused children to be attacked by the virus. Since people were no longer in contact with open sewers and other unsanitary conditions which had exposed them to small amounts of the polio virus as infants, when paralysis is rare, the dis...
Salk’s research led him to create a vaccine different from any other by using 3 different kind of killed polio virus. In an article it says,”Using formaldehyde, Salk killed the poliovirus, but kept it intact enough to trigger the necessary immune response”(Salk’s institute 1). Salk 's decision to create a vaccine out of inactivated virus was not the strongest protector, but was made strong enough to cure and lower the risk of infection within patients. It was one of the first times someone attempted to take a completely opposite approach than what scientist thought was best. As he said in an interview, “ ‘The principle I was trying to establish was that it was not necessary to run the risk of infection, which would have been the case if one were to try to develop an attenuated or weekend polio virus vaccine’ ”( Salk 2). By taking the risk of creating a vaccine that contradicted what a normal vaccine, was it helped give the United States another weapon to fight back polio without exposing americans to the risk of contracting the disease. His different approach to find a remedy may have been looked down on, but it provided the first protection ever for polio which created hope and has contributed to less fatalities today. Scientists in the medical world began to criticize Salk’s vaccine and gave preference to a polio vaccine that was later created by Sabin out of a live polio virus. Medical professionals saw Salk’s vaccine as useless and thought Sabin’ s vaccine was the best alternative. "the oral polio vaccine also came under attack in the united states for causing eight in ten cases of polio every year”( poliomyelitis 4). Sabin’s vaccine may have been stronger but at least Salk’s never provided a risk of the patients being injected run a risk of being infected again. Salk’s vaccine has provided less risk of a patient to relapse into polio again.
In an interview with the American Academy of Achievement, Jonas Salk stated “Risks, I like to say, always pay off. You learn what to do, or what not to do.” As a man of science, Salk truly believes and lives these words every day. In his career he has surely taken many risks, chasing down new theories and ideas, only to lead to a dead end road. But one day, he stumbled upon an idea, and took a risk that left an impact on humanity forever. Not only has Jonas Salk left his stamp on the medical world with the development of the Polio vaccine, but his team continues to conduct groundbreaking research on some of today’s most deadly diseases.
The article’s information is presented with the goal of informing a reader on vaccines. The evidence is statistical and unbiased, showing data on both side effects and disease prevention, providing rates of death and serious illness from both sides. This evidence is sourced from a variety of medical organizations and seems reliable, logical, and easily understood, no language that would inspire an emotional response is used. The validity of studies is not mentioned in the article, but it does encourage readers to investigate further to help make a decision. The article allows a reader to analyze the presented evidence and come to their own
Albert Sabin, the developer of the polio vaccine once said, “Without animal research, polio would still be claiming thousands of lives each year.” Polio is a deadly disease caused by a virus that spreads from person to person. This infectious disease renders the brain and spinal cord helpless while also ensuring a permanent case of paralysis to the victim. According to the Centers for Disease Control and Prevention, “…13,000 to 20,000 para-lytic cases were reported annually,” before the 18th century. After the introduction of the polio vaccine, “…a total of 2,525 paralytic cases were reported, compared with 61 in 1965.” This dramatic decrease in the prominence of the polio disease can only be attributed to the success of animal testing. Animal experimentation is used in the research of genetics, drug testing, biology, toxicity testing, cosmetic testing, and many other fields. Despite all of its beneficial traits, animal testing has been wildly controversial over the past decades because of its perceived unethical treatment towards animals. Although animal testing may be deemed unethical by many, it is a form of medical testing that has not only saved lives but has also greatly revolutionized the medical world.
The unforgettable story of vaccines is a story of triumph and controversy. The saddest part of the story is persistent ignorance and a lack of education, comingled with the personal need of some parents to explain away the problems of their children, have caused the controversy to arise. The good news is that the triumphant reality of vaccines as a whole is still the larger enduring legacy. The human papillomavirus vaccine is not an exception to this rule; in fact despite all the controversy surrounding the vaccine, it is one of medicine’s greatest lifesaving gifts to us.
Vaccines have been used to prevent diseases for centuries, and have saved countless lives of children and adults. The smallpox vaccine was invented as early as 1796, and since then the use of vaccines has continued to protect us from countless life threatening diseases such as polio, measles, and pertussis. The Center for Disease Control and Prevention (2010) assures that vaccines are extensively tested by scientist to make sure they are effective and safe, and must receive the approval of the Food and Drug Administration before being used. “Perhaps the greatest success story in public health is the reduction of infectious diseases due to the use of vaccines” (CDC, 2010). Routine immunization has eliminated smallpox from the globe and led to the near removal of wild polio virus. Vaccines have reduced some preventable infectious diseases to an all-time low, and now few people experience the devastating effects of measles, pertussis, and other illnesses.
Jonas Salk M.D. developed the polio vaccine. Salk's vaccine was composed of a "killed" polio virus. This virus kept the ability to immunize while preventing the infection of the patient. Later a "live" vaccine was developed from the live polio virus. This "live" vaccine could be administered orally as opposed to the "killed" vaccine which required an injection. There was some evidence that the "killed" vaccine didn't completely eliminate the virus in the patient. United States public health authorities decided to distribute the oral "live" vaccine to eliminate the polio virus instead of Salk's "killed" vaccine. Unfortunately, the "live" vaccine infected some people instead of immunizing. Countries that used Salk's "killed" vaccine have nearly eradicated the virus.
The major controversy about immunizations is whether or not they are safe. Most of the arguments against vaccination appeal to parents’ understandable deep-seated concerns for the health of their children, particularly with very young babies. Unfounded allegations regarding adverse effects from vaccines typically target feared diseases, or syndromes or conditions of unknown or uncertain cause, such as autism, sudden infant death syndrome and multiple sclerosis. The most asked question when debating this topic is of course whether or not vaccines are safe or if in reality it is more dangerous to get them, then to not get them.
A prevailing argument that pro-voluntaristic individuals frequently make is that vaccines have the potential to be harmful to individuals; a primary motive behind this pertains to an alleged correlation that exists between thimerosal, a component of vaccines, and countless disorders including autism (Benjamin, 2003). According to Barbara Loe Fisher, president of the National Vaccine Information Center, “When you take a look at the ever-increasing numbers of doses of vaccines babies have gotten over the past two decades and you see this corresponding rise in chronic disease and disability in our children, it is out of control” (Benjamin, 2003). Many speculated that the mercury contained within the thimerosal was to blame for this. However, according to the Centers for Disease Control and Prevention (CDC), thimerosal contains a form of mercury known as ethylmercury that quickly evacuates the body and cannot cause adverse reactions unless exposure involves abnormally large doses (Centers for Disease Control and Prevention, 2015). Nevertheless, a fair handful of United States citizens are medically unable to receive vaccines; for example, out of a billion people, nearly 250,000 possible vaccine reactions were documented