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Ethics of human stem cell cloning research
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A somatic cell nuclear transfer, which is also commonly referred to as a SCNT, is the process in which the result is considered a clone. This process includes multiple steps, one in which being the transfer of a somatic cell’s nucleus into an enucleated egg cell. This results in an embryo, which has a variety of uses. If the embryo is used for it’s stem cells, then the outcome will be a genetically identical organ instead of a full clone. This type of cloning could have many practical applications in the future. If the embryo is instead inserted into a uterus, the embryo will grow into a full clone. This type of cloning is called reproductive cloning and both types of cloning have sparked controversy among many due to a variety of ethical
This tadpole was reported to have developed normally. In 1975 SCNT was again used to create a mammalian embryo from an enucleated rabbit egg and a rabbit nucleus. The embryo resulting from this experiment was not placed into a womb, so it never developed into a full rabbit. In 1985 SCNT was used by scientists to create three lambs. The lambs were made by using nuclei from early embryonic cells, not adult cells. This experiment was considered successful because this was the first time a mammal was successfully cloned using SCNT. In 1997 a primate was cloned using SCNT to fuse embryonic cells and enucleated primate egg cells. The result, after implantation into a womb, was primates. Also in 1997, a sheep was created using SCNT. This experiment was significant because she was made from genetically engineered cells with “factor nine”. After birth, this cloned, transgenic sheep produced the same “factor nine” proteins in her milk. There could be many applications for similar types of cloning in the future of medicine. From 1998 to 2000, mice, a cow, pigs, and a goat were all cloned using SCNT. In 2007, somatic stem cells were created from a primate through SCNT by fusing an adult monkey nucleus and an enucleated egg cell. This is one of the first examples of successful therapeutic cloning and led many scientists to wonder about the possibility of therapeutic cloning in humans. In 2003 a human cloning company, Clonaid, claimed to have produced the first human clone named Eve. There has been no DNA evidence to support this statement and many have concluded that this is a false claim. In 2013, OHSU was able to turn human skin cells into embryonic stem cells, which was a huge cloning
Therapeutic cloning is the process whereby parts of a human body are grown independently from a body from STEM cells collected from embryos for the purpose of using these parts to replace dysfunctional ones in living humans. Therapeutic Cloning is an important contemporary issue as the technology required to conduct Therapeutic Cloning is coming, with cloning having been successfully conducted on Dolly the sheep. This process is controversial as in the process of collecting STEM cells from an embryo, the embryo will be killed. Many groups, institutions and religions see this as completely unacceptable, as they see the embryo as a human life. Whereas other groups believe that this is acceptable as they do not believe that the embryo is a human life, as well as the fact that this process will greatly benefit a large number of people. In this essay I will compare the view of Christianity who are against Therapeutic Cloning with Utilitarianism who are in favour of Therapeutic Cloning.
Understanding the facts as well as procedures between the many different types of cloning is very crucial. When everything boils down there are three types of cloning known as DNA cloning, therapeutic cloning and reproductive cloning. DNA cloning is the copying of a gene in order to transfer it into another organism which is usually used by farmers in most of their crops. Therapeutic cloning is the use of stem cells used to help take the place of whatever cell is missing which is potentially used to help the ill. Stem cells contain the potential to grow and help replace the genes that are missing in order to fix whatever is genetically wrong with your body or any genes that you may be missing. Reproductive cloning actually produces a living animal from only one parent. The endless possibilities and perhaps hidden motives of using genetic engineering are what divide as well as destroy the scientific community’s hope for passing laws that are towards pro cloning. Many people within soci...
Kevin T. Fitzgerald divided potential scenarios for using cloning technology into three categories: "Producing a clone in order to save the life of an individual who requires a transplant; making available another reproductive option for people who wish to have genetically related children, but face physical or chr...
...velopment of tissues to replace damaged organs in the human body. Scientists have discovered for the first time how stem cells could be generated from embryo’s that were produced using adult stem cells.
Cloning is a recent innovative technique the National Institute of Health defines as a process employed to produce genetically identical copies of a biological entity. Depending on the purpose for the clone, human health or even human life can be improved or designed respectively. “Somatic cell nuclear transfer (SCNT) is the most common cloning technique. SCNT involves putting the nucleus of a body cell into an egg from which the nucleus has been removed."^1 From this technique, an embryonic cell is activated to produce an animal that is genetically identical to the donor. Today, human cloning still remains as a vision, but because of the success of Dolly, the lamb, researchers are becoming more confident in the ability to produce a genuine
First and foremost, it is important to discuss what human cloning is. It is the conception of in vitro embryos that produces “individuals that are exact genetic copies of the donor from whom the DNA was obtained” (Munson 366). In Laymen’s terms, cells are inserted from the donor host into an unfertilized egg from another host (meaning it is asexual) and the new egg is transferred into the surrogate mother where it will foster into an embryo, if effective.
Cloning is, and always has been an extremely contentious topic. To some, the ethical complications surrounding it, are far more promiscuous than what scientists and medical experts currently acknowledge. Cloning is a general term that refers to the process in which an organism, or discrete cells and genes, undergo genetic duplication, in order to produce an identical copy of the original biological matter. There are two main types of artificial cloning; reproductive and therapeutic, both of which present their respective benefits and constraints. This essay aims to discuss the various differences between the two processes, as well as the ethical issues associated with it.
Since 1885, there have been a number of researchers, scientists, geneticists, reproductive technologists and embryologists, such as August Weismann, Hans Spemann, Walter Sutton, Paul Berg, Steen Willadsen, et al., who have contributed much to the research and development of our current concepts of cloning. Particularly two of the more recent renowned contributors to cloning research and experimentation are Ian Wilmut, a Ph. D. in animal genetic engineering, and Richard Seed, who founded Fertility and Genetics in the 1980s.
Spearmann thought of cloning as a way to study cell differentiation. Briggs and King used the technique of nuclear transfer on amphibians and it was successful (Campbell). “Subsequently John Gurdon demonstrated the potential to reprogram differentiated cells by producing adult Xenopus using epithelial cells from developing tadpole intestine as nuclear donors,” says Alberio Campbell. Unfortunately, later studies show that this method of cloning tadpoles didn’t allow them to develop to the adult stage of life (Campbell). “The use of enucleated metaphase II oocytes as recipient cytoplasts proved more successful and in 1986 resulted in the production of live lambs using blastomeres from 8 to 16-cell stage embryos as nuclear donors,” says Campbell. This success in sheep was also used on other mammals such as cattle and swine. There were limitations to the technology. First, the “frequency development was very low”...
Ever since the successful birth of Dolly on July 5, 1996, the scientific community as well as the public have been engulfed in the idea of reproductive cloning, its benefits, and its potential threats. This well-publicized event was a giant steppingstone in understanding and using the techniques of gene cloning and reproductive cloning. By using a technique known as Somatic Cell Nuclear Transfer, scientists at the Roslin Institute removed the nucleus from an oocyte (unfertilized egg), and then fused this newly enucleated cell with a donor cell (with complete nucleus). This new embryo was then implanted into the womb of a surrogate mother ewe. In total, out of 277 fused cells, 29 successfully developed into embryos, while only one of these resulted in a successful live birth (a total success rate of 0.4%) (Wong, 202). Dolly was the first living mammal to be cloned by this fast and accurate process of somatic cell nuclear transfer, but was by no means the first animal to be cloned. The first...
Perhaps cloning is not the answer and our society should leave reproduction up to the natural ways. But then one must ask themselves the question of 'why not'. Is there some horrible outcome that will back fire due to the aberrant ways of creating a child? Is bring...
been made possible but yet a majority of them have died in early stages of development or after birth according to the study of the cloned sheep, Dolly (Magalhães 1). Those who make it suffer from several defects acquired from birth (Magalhães 1). During recent experimentation it took scientist Ian Wilmut of the Roslin Institute in Edinburgh, Scotland, and his colleagues who created Dolly (a cloned sheep) 277 tries before they got a healthy, feasible lamb (Human Cloning 1). Due to the complication of human cloning even more deaths and deadly birth defects can be expected (Human Cloning 1). Even though human cloning has never been performed, one likely possibility is that babies born through this process will as well feature lethal birth defects (Magalhães 1).
In recent years, the development of cloning technology in non-human species has led to new ways of producing medicine and improving our understanding of development and genetics. But what exactly is human reproductive cloning and how has this technology been developed? The term “cloning” refers more specifically to a process known as somatic cell nuclear transfer. In this process, the DNA from the cell of ...
Recent discoveries involving cloning have sparked ideas of cloning an entire human body (ProQuest Staff). Cloning is “the production of an organism with genetic material identical to that of another organism” (Seidel). Therapeutic cloning is used to repair the body when something isn’t working right, and it involves the production of new cells from a somatic cell (Aldridge). Reproductive cloning involves letting a created embryo develop without interference (Aldridge). Stem cells, if isolated, will continue to divide infinitely (Belval 6). Thoughts of cloning date back to the beginning of the twentieth century (ProQuest Staff). In 1938, a man decided that something more complex than a salamander should be cloned (ProQuest Staff). A sheep named Dolly was cloned from an udder cell in 1997, and this proved that human cloning may be possible (Aldridge). In 1998, two separate organizations decl...
Many patients in hospitals are waiting for transplants and many of them are dying because they are not receiving the needed organs. To solve this problem, scientists have been using embryonic stem cells to produce organs or tissues to repair or replace damaged ones (Human Cloning). Skin for burn victims, brain cells for the brain damaged, hearts, lungs, livers, and kidneys can all be produced. By combining the technology of stem cell research and human cloning, it will be possible to produce the needed tissues and organs for patients in desperate need of a transplant (Human Cloning). The waiting list for transplants will become a lot shorter and a lot less people will have to suffer and die just because they are in great need of a transplant....