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Oxytocin 4CH
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Oxytocin is a hormone, predominately belonging to mammalian family; it is secreted by the posterior pituitary gland. After its release in the blood stream it cannot re-enter the brain due to the presence of blood brain barrier .Oxytocin is a hormone that has both peripheral and central actions (32). They are synthesized in the magnocellular neurons present in the supra–optic and Para –ventricular nucleus present in the hypothalamus. The universally known functions would include its role at the time of labour and ejection of milk. The functions which remain partially unknown are in erectile responses, ejaculation, bonding, and feeling of love and maintaince of eye contact during a conversation. This review is aimed at bringing into nutshell the common functions, defiency states and the commercially available forms of the same.
Key words:
Oxytocin, bonding, pitocin, labour.
Introduction:
Oxytocin is a mammalian hormone predominantly, in human beings it is synthesized by specialized cells in the supra optic and paraventricular nucleus of the hypothalamus. Oxytocin acts as a neurotransmitter in the brain (15). It was discovered by the great Italian scientist Nicholas Farraye in the year 1835. It has a molecular formula of C43H66N12O12S 2. The structure of oxytocin is similar to that of vasopressin but with a few differences.
Apart from the well known function of uterine contraction and milk ejection, oxytocin is said to play a major role in creating an effective bond between child and mother, in trusting people, maintain eye to eye contact during a conversation. Most of us regard Oxytocin to be a hormone which is found only in the female counterparts, fortunate...
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... Oxytocin, a naturally occurring hormone in the human body, is said and proved to produce many important physiological actions. Oxytocin when present in optimum level helps to maintain emotional homeostasis, pleasure, love, orgasm and also improves social memory and cognition. Deficiency of oxytocin in the amygdala causes anxiety and fear which are often found in conditions like autism and Schizophrenia. Deficiency of the same at the time of labour leads to uterine inertia and post partum bleeding. These complications are trespassed by the commercial availability of the hormone in various forms. The synthetically produced, oxytocin replacing hormones, pose certain potential threats to homosapiens.Thus further research is being conducted to coin substances that mimic the property of natural oxytocin and also discards the risk which occurs due to external intake.
The location of the pituitary gland is in the sella turcica of the sphenoid bone and attaches to the hypothalamus(Marieb & Hoehn 441). The Hypothalamus is included in the function of the pituitary gland as it sends chemical stimulus to it(Marieb & Hoehn 442).Part of the pituitary is called the “ master endocrine gland” due to the fact that is produces many hormones that affect the whole body(Shannon 175).This part of the pituitary gland is called the anterior pituitary(Marieb & Hoehn 601). There are six hormones that the anterior pituitary secretes normally. These Hormones are growth hormones,thyroid stimulating hormones,adrenocorticotropic hormones,luteinizing hormones,follicle stimulating hormones and prolactin hormones( Shannon 175).The Hormone prolactin is one that in normal function stimulates the act of lactation for new mothers to feed their baby(Shannon 175).
While the respiratory and cardiovascular systems are most reliant on one another, all body systems require a functioning circulatory cycle in order to thrive. Blood circulation and consistent transfer of oxygen to cells is required to maintain cell and tissue life. Disturbances to this process will cause cells and tissues to die (Red Cross 48). This state of balance and functioning body systems is referred to as homeostasis, defined as a “condition of equilibrium in the body’s internal environment due to constant interaction of body’s many regulatory processes” (Tortura 8). Changes or disruptions to homeostasis are regulated by the Endocrine and Nervous systems of the body. The endocrine system is made up of glands placed throughout the body
When tryptophan enters the body in the presence of pyridoxine (B6), it is converted into 5-Hydroxy L-Tryptophan, or 5-HTP. This, in turn, converts into seratonin, a neurotransmitter. Neurotransmitters are extremely important at the neurochemical and physiological level, as they carry impulses between nerve cells. Seratonin can be converted into melatonin, which regulates the sleep wake cycle. Elevated levels of seratonin are credited with relief of depression, reduced pain sensitivity, lessened anxiety and stress, and a feeling of calm and sleepiness.
The anterior pituitary is an endocrine gland controlled by the hypothalamus in several different fashions. Releasing and release-inhibiting hormones are synthesized in the paraventricular, periventricular, and the supraoptic nuclei of the hypothalamus. They control anterior pituitary hormone secretion. Paravocellular neurons in these nuclei send their axons into the tuberoinfundibular tract and terminate on a capillary bed of the superior hypophyseal arteries located around the base of the median eminence. A given paravocellular neuron may release one or more releasing factor into the capillaries that coalesce in six to ten small straight veins that form the hypophyseal-portal blood circulation which descends along the infundibular stalk and forms a second capillary plexus around the anterior pituitary. The releasing-hormones gain access to the five distinct types of target cells in the anterior pituitary back into the capillary bed that then drains into the systemic circulation and transports the hormones to peripheral target tissues. The target tissues are stimulated to produce final mediator-hormones that induce the physiologic...
The article '' love: the right chemistry'' by Anastasia Toufexis efforts to explain the concept of love from a scientific aspect in which an amateur will understand. Briefly this essay explains and describe in a scientific way how people's stimulation of the body works when you're falling in love. The new scientific researches have given the answer through human physiology how genes behave when your feelings for example get swept away. The justification for this is explained by how the brain gets flooded by chemicals. The author expresses in one point that love isn't just a nonsense behavior nor a feeling that exhibits similar properties as of a narcotic drug. This is brought about by an organized chemical chain who controls different depending on the individual. A simple action such as a deep look into someone's eyes can start the simulation in the body that an increased production of hand sweat will start. The tingly feeling inside your body is a result of a scientific delineation which makes the concept of love more concretely and more factually mainly for researchers and the wide...
Evil has a direct link to oxytocin being released into the brain. (Zak 1) The 5% that don’t share many traits with psychopaths. (Zak 1) Not all evil people don't have the ability to release oxytocin. People who release oxytocin when given a positive signal tend to be “normal people. 95% of people release oxytocin when given a positive social signal. (Zak 1) Most people are not evil, the number may
Cuddling. That strange behavior exhibited by every woman that falls under the AXE effect and that lasts all day.” The AXE company is claiming responsibility for the side effect of cuddling after sex. However, this “side effect” is actually caused by the dopamine, prolactin, and oxytocin hormones that are released in the body after orgasm. (Last)
In the story, The Crucible, John Proctor has an affair with Abigail Williams. This affair may have been the initial problem leading to the accusations of witchcraft. The young teenage girl falls hopelessly in love with John Proctor after their sexual encounters. But can she help it? Sex is a fascinating topic when it comes to the different views on it between girls and boys. Boys tend to use sex for sexual pleasure, but on the other hand girls have a tendency to focus on the love element of sex. Due to studies done at Rutgers University, New Jersey, scientists have found an explanation as to why women become much more attached to a man after sex. Oxytocin
Abstract: The human brain is the most complex organ in the body. Its functions control every aspect of life. It is important to attempt to comprehend the workings of the brain and to learn the effects of natural and unnatural substances on it. In order to look at chemical effects on the brain, one must first get an understanding for the chemicals as well as how the brain works to interpret and react to signals set out by these chemicals, rhythmically and physiologically. Several chemicals observed include: cocaine (and other chemicals), seratonin, and melatonin.
5. Brennan, A. M., & Mantzoros, C. S. (2006). Drug Insight: the role of leptin in human physiology and pathophysiology—emerging clinical applications. Nature Reviews Endocrinology , 318-327.
Lischke, A., Gamer, M., Berger, C., Grossmann, A., Hauenstein, K., Heinrichs, M., . . . Domes, G. (2012). Oxytocin increases amygdala reactivity to threatening scenes in females. Psychoneuroendocrinology, 37(9), 1431-1438. http://dx.doi.org/10.1016/j.psyneuen.2012.01.011
In the brainstem, the most primitive part of the brain, lie clusters of serotonin neurons. The nerve fiber terminals of the serotonergic neurons extend all throughout the central nervous system from the cerebral cortex to the spinal cord. This neurotransmitter is responsible for controlling fundamental physiological aspects of the body. In the central nervous system (CNS), serotonin has widespread and often profound implications, including a role in sleep, appetite, memory, learning, temperature regulation, mood, sexual behavior, cardiovascular function, muscle contraction, and endocrine regulation. Not only does this bioamine control physiological aspects of the body, but it also has an involvement in behaviors like eating, sleeping and aggression. Serotonin has been noted to produce an inhibitory effect on the nervous system that calms, soothes and generates feelings of general contentment and satiation.
number is increasing as more screening has become available, and there is no cure in sight. Autism is a disorder that is characterized by frequent deficits in communication and social interaction, a lack of trust in others, and generally poor social skills. However a new and promising treatment is arising in the form of the hormone oxytocin. Oxytocin is a hormone that is found in mammals that has various functions. One effect of oxytocin is that it seems to increasing trust in social interactions. There are very few studies that have tested the effect that oxytocin has on increasing trust and social skills in people, and therefore more testing is needed. Although there are not enough long term studies, the short term response to oxytocin is positive. Recent research indicates oxytocin treatments for autistic patients correlate with improvement in facial recognition, and recognizing emotions of others. Therefore, using oxytocin provides a promising new approach to treating autism.
Pheromones are natural scents, which play an important role in sexual communication. Animals and humans release masses of biological chemicals in tears, saliva and perspiration. These aromas convey signals relating to mood, status, drive and health to the subconscious awareness of the female. The dominant male will exude more of these biological attractants than his submissive counterpart, consequently he inevitably attracts more females and enjoys more conquests. This philosophy holds well in the animal world, pheromones are consciously detected over considerable distances and serve at times in place of spoken communication. They help animals mark territory, recognize mates, and signal sexual interest. For example, female dogs in heat leave their pheromone and can attract male dogs over a mile away (5).
The second aspect of this presentation was the 5-HT Receptor Antagonist. These antagonists are capable of decreasing the effect of NPY levels within the body. One antagonist, in particular, was shown to have a great effect on NPY effect, known as DOI. It was found that DOI blocks NYP responses inside the brain. One specific part of DOI was signaled out as being responsible for the blockage of NPY, known as 2A. Even though the DOI is able to decrease the sense of hunger, it is not used in humans because it causes very bad after effects, especially great nausea.