Sucralfate Case Study Essay

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• Post-fistulotomy, patients often experience bleeding, pain, and delayed wound healing. • Sucralfate has antioxidant and antimicrobial effects. It also increases prostaglandin E2 secretion to increase mucus formation and blood flow. Additionally it increased the amount of epidermal growth factor, leading to the formation of more blood vessels (angiogenesis). • Sucralfate is an effective pain reducer and has been used in oral mucositis and post-tonsilectomy pain2-4 • When used topically, sucralfate exhibits analgesic effects post-hemorrhoidectomy5. The authors conducted a prior study and obtained similar analgesics effects 48 hours post-hemorrhoidtectomy.6 • Study not registered on clinicaltrials.gov • Study is registered in the Iranian Registry …show more content…

However the registry states that data was collected every 2 weeks. • Funded by the Mazandaran University of Medical Sciences Ethics committee • Authors declared no conflict of interest • Single-centered and parallel • Prospective randomized placebo-controlled trial • Double-blind • A nurse, unaware of the trial’s protocol and did not participate in the trial procedure, performed the randomization. • Blinded players: Health care providers, surgeon, data collectors, and the patients themselves • The blinded players did not know which treatments were being used for each patient until the end of the trial • Setting: Iman Khomeini educational hospital located in Sari, Mazandaran province in Iran. • Trial period: February 2014-March 2015 • All patients underwent elective fistulotomy • Patient ages ranged from 20-70 years • Exclusion criteria: multiple fistulas, previous fistula surgery, long-term use of corticosteroids, hx of IBD, radiation exposure, or use of chemotherapy within the last 2 …show more content…

• Primary outcomes: Postoperative pain intensity and pain upon defecation • Secondary outcomes: Anal pruritis, wound discharge, wound infection, bleeding, flatal incontinence, further curettage, and other adverse drug events • Pain was assessed using the visual analogue scale (VAS) based on the patient’s subjective perception. Scale ranged from 0-10 with 10 being the worst pain • The outcomes were examined at each weekly post-op clinic visit • Post-op clinic visits were done each week after the fistolotomy for 5 weeks. • Sucralfate ointment group: 24 patients • Placebo ointment group: 24 patients • Sample sizes were calculated by estimating a 95% confidence interval, 80% power, and 25% reduction in intensity of pain. This calculation determined that there should be at least 18 patients per group. • Utilized the SPSS software • Compared the means using independent sampled t-tests and ANOVA • The qualitative data (secondary outcomes) were compared using the chi-squared test • Ps G 95% CI Lower Limit 95% CI Upper Limit 1 -0.915 -1.371 -0.458 2 -1.459 -1.78 -1.138 3 -1.24 -1.506 -0.974 4 -1.847 -2.135 -1.559 5 -1.456 -1.706

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