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Immunopathology(quetion
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Overview:
Henoch-Schonlein Purpura (HSP) is an inflammatory disorder, more commonly known as Spring Fever. It coined this nickname from the high occurrence in the beginning of spring, triggered by respiratory illnesses from winter. HSP was first noted in 1801 by Dr. William Heberden, a london physician, who made case notes on a young boy aged five that was displaying, what we know to now be, typical HSP symptoms.
HSP is a type of vasculitis, or inflammation of the blood vessels, that targets mainly children between two and thirteen years old. The disorder itself is rare, and recurrence even more rare, with adults showing much more severe symptoms than children on average. If untreated HSP can be fatal due to kidney and intestinal complications.
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This leads to the inflammation and potential damaging of the kidneys and eventual kidney disease unless treated. HSP causes an extreme and severe form of IgAN. There are two forms of IgA, IgA1 and IgA2. IgA1 is the only form involved with HSP. “IgA with diminished hinge-region glycosylation are prone to aggregate into macromolecular complexes. These complexes activate the alternative pathway of complement, and then deposit into the renal mesangium” (Saulsbury). The bodies immune response gets triggered by an upper respiratory illness, and produces IgA antibodies. If these IgA antibodies have hinge regions that are not fully developed correctly then they go haywire; producing more and more and clumping together to form complexes that deposit themselves into the kidneys. These malfunctioning IgA1 antibodies also deposit themselves into blood vessel walls, causing them to rupture and blood to pool at the surface of the skin, the cause of the characteristic purple purpura rash (Saulsbury). Individuals who suffer from HSP do not always produce these malfunctioning IgA antibodies, and many researchers are puzzled by and still researching the “come and go” effect of IgAN affliction in correspondence to
Though Hidradenitis Suppurativa occurs in the glandular areas of the body, it doesn’t have anything to do with the glands. HS develops when hair follicles become blocked and swollen. The direct cause of this blockage is idiopathic but many factors may play a key role, such as, obesity, smoking, hormones and genetics. For reasons unknown women are more likely to inherit or acquire this condition, but that doesn’t mean men can’t develop this issue as well. Most cases tend to develop after puberty occurs, usually in a person’s teens or twenties, though children can develop this condition as well.
Some cases are severe and patients can develop hemolytic uremic syndrome, or HUS, which is a type of kidney failure. There have been no cases of HUS or deaths from this outbreak.
Glomerulonephritis, as a defined disease, is very broad in terms of a medical condition and is usually only diagnosed after a routine medical check-up or tests for another condition discover; the symptoms may not be obvious. This disease targets the membrane tissues made of tiny filtering cluster units within the kidneys called glomerulus, which comes from a Greek word meaning filter (NIH, 2014). This illness presents as an inflammation of the tiny filtering units called glomeruli of the kidneys that can be caused by a passing illness associated with an infection or as a result of an autoimmune disease (Nemours, 1995-2016). Glomerulonephritis is a multi-symptom disease caused by genetics or environmental factors that can have variable degrees
First, in Divergent, Veronica Roth uses character archetypes to show how Tris is a brave hero. When Tris first arrives in Dauntless and is still an initiate going through training, she is still getting used to being brave. Tris is practicing throwing her knives and is getting pretty good but next to her Al is struggling. Eric is angry with Al, so Eric makes Al stand in front of the target and is going to have Four throw knives at Al. Tris is angry so she says to stop and ends up having to stand in front of the target instead of Al. This shows how brave she is, standing up for her friend and having knives thrown at her. "Stop it" Four turns the knife in his hand, his fingers moving painstakingly over the metal edge. He gives me such a hard look
Heroes and villains, your usual story right? Well Harper Lee’s To Kill A Mockingbird is far from it. In this novel Harper Lee uses southern gothic literature to tell the story. Gothic literature is a genre of southern writing. The stories often focus on grotesque themes. While it may include supernatural elements it mainly focuses on damaged, even delusional characters. In her novel Harper Lee utilizes the gothic archetypes of the hero, the monster, and the innocents to portray Maycomb’s crisis of conscience during the trial.
The article named “spring awakening” wrote by Jose Vargas describes the impact of social media in converting the mentality of young Egyptian generations into bold and defend their inalienable rights as a citizen. This article justifies how social media can mobilize a tremendous number of people to stand up for their rights. The reasons that inspire my emotion is emerging of “Wael Ghonim” as a legendary vocal figure of action for change, revelation of social media as earthquake for change, and fundamental soci-political change.
The story of Summer, by David Updike, is set during that idyllic time in life when responsibility is the last word on anyone's mind. And yet, as with all human affairs, responsibility is an ever-present and ever-necessary aspect to life. What happens when the protagonist, Homer, loses his awareness of a certain personal responsibility to maintain self-control? Homer's actions increasingly make him act foolishly, internally and externally. Also, how does Homer return to a sense of sanity and responsibility? To a degree, I would say that he does.
All the novels that I have read in class this year have been absolutely fascinating and remarkable. Each one captivated me in an indescribable way. However, there is a particular novel that stood out to me. It is a novel that is highly enjoyable and I recommend it to anyone looking for a poetic and simple book to read. That novel is One Crazy Summer by the distinguished author of books for children and teens, Rita Williams-Garcia.
25. Dorothy Horstmann, "Three Landmark Articles about Poliomyelitis," Medicine (September 1992): 320-25, at p. 322.
“Immune Response: MedlinePlus Medical Encyclopedia.” National Library of Medicine - National Institutes of Health. Web. 18 Dec. 2011. .
Mumps is primarily a childhood disease, occurring most frequently between the ages of 5 to 9, although it was also known as a problem for soldiers during war because of the sanitary conditions and close proximity. For instance, in World War I only influenza and gonorrhea were more prevalent among the armies. It replicates inside the nose, throat, and regional lymph nodes. The virus incubates for about 14-18 days, and then a viremia occurs for about 3-5 days. During the viremia it can spread to the meninges, salivary glands, testes, ovaries and pancreas. Out of the infected population, 30 to 40% get swollen parotid salivary glands, with most of the rest being asymptomatic or having only respiratory problems. Around 60% of patients have asymptomatic meningitis, with up to 15% progressing to symptomatic. Encephalitis is also possible, occurring in around 5/100,000 cases. The encephalitis almost always results in some permanent hearing loss, and was historically the leading cause of hearing loss in children. Orchitis (testicular swelling) happens in up to 50% of post-pubertal males, with oophritis (ovarian swelling) happening in only 5% of women. Orchitis often results in testicular atrophy but very rarely in sterility.
The Hero: "Often, for undaunted courage, fate spares the man it has not already marked."
There are several different ways that pneumonia is classified such as hospital acquired pneumonia, ventilator-associated pneumonia, and community acquired pneumonia. Hospital acquired pneumonia, HAP, is an infection that was not present at the time of admission but develops 48 hours or more afterwards. Some of the most common bacteria in this class are Pseudomonas aeruginosa, Staphylococcus aure...
I chose the first picture for the relationship between Autumn and Sylv. Although they were a couple, they were best friends first and foremost. They didn’t let anyone stop them from being who they were. They were looked down upon in society and they were thought of being crazy or unethical. Yet this didn’t stop them. Not even Autumn’s brother. In my opinion, if you love someone, you can’t stop yourself from loving them. So it’s unfair to tell someone in a same sex relationship that they are wrong or a sinner for loving who they love. And as many people have stated, if you love someone let them go, this is demonstrated with this couple in many ways. For one, their willingness to let each other go to colleges far away from each other to pursue
This disease was first diagnosed in 1918 and it was referred to as the “Spanish Flu” or “La Grippe.” To this day it is thought to of been the same strain as the swine influenza however it is still unclear. For this particular outbreak it’s not exactly know whether humans contracted the virus from pigs or vice versa. Either way between 20-40 million people died from it. The first confirmed case of H1N1 in the U.S. was diagnosed on April 15th, 2009. The CDC quickly began developing a vaccine due to the fact that it was declared a public health emergency about a week later by the government. It tu...