Sodium Diclofenac Research Paper

Introduction:-

Sodium diclofenac:-

Sodium diclofenac (SDF), a sodium salt of 2-[(2,6-dichlorophenyl)aminophenyl]-acetic acid , is a potent analgesic, anti-inflammatory and anti-arthritic agent in humans, aceclofenac, has also anti-inflammatory activity, and it is metabolized to diclofenac . NSAIDs can cause adverse health effects on humans such as aplastic anemia, gastrointestinal disorders and agranulocytosis and changes in renal function. It is also used for animal medication. This drug is taken orally and can exist in body fluids like blood plasma, urine, and also in animal milk In fact, contaminated milk may indicate allergic reactions or cause problems due to bacterial resistance to medicine treatments. This drug may also exist in other places as wastewater, due to pharmaceutical wastes.

Electro-membrane Extraction:-

Microextraction techniques, like hollow fiber liquid phase microextraction (HF-LPME), was developed and used in a remarkable analysis. HF-LPME has been introduced as an very good alternative extraction technique than the classical ones, that due to it is ease of operation, low cost, precision, sensitivity and it’s environmentally friendly technique. However, this technique has major problem that it need long time some times more than 25 min.

Now days, this extraction technique was enhanced by the introducing an electrical potential. In this technique, which called electro membrane extraction (EME), the same setup for HF-LPME, plus the using of two electrodes. The driving force (which makes the extraction faster) in EME is the migration of the ions due to the response electrical potential. One electrode is put in the acceptor phase in the fibre, and the one is placed in the sample solution. That can be obvi...

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...g rate 1200 rpm, temperature 30 ◦C, Each experimentwas done three times.

HPLC-UV chromatographic conditions:-

The first component in the Mobile phase is phosphate buffer (pH 2.5) and the second component is methanol. The elution was isocratic eluting at 30% of the buffer and 70% of the methanol at a flow rate of 1mL min−1, The wavelength used for UV-detector was 280 nm, HPLC column C18 (150 mm×4.6 mm, 5µm), and the injection volume was 20 µL.

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Comparing the proposed method with other different methods :-

Conclusion:-

- This technique a significant difference in limit of detection and the required time for analysis when it compared with number of other technique.

- This method show highly precision, sensitivity for separation and clean up for the sample in different matrixes like (waste water, bovine milk, urine and blood plasma).