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History of vaccinations
History of vaccinations
Eradication of smallpox history
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Introduction
In the past, people believed that the deities existed, and they controlled the world. Also, human beings were not defeated by some powerful diseases, and they believed that the diseases came from God’s punishment. It killed a great number of people. People felt weak, apprehensive, and terrified. The main reason why people were terrified of the diseases is that they couldn't find some methods to treat or prevent the diseases. In history, many deadly diseases caused huge damage to cultures or countries, so we should have known smallpox that had effect and cause many people between present and the past.
Background
Most people known that smallpox was a serious disease, but they were not clearly understanding what causes smallpox was. Some simple introductions about smallpox is that smallpox was one kind of contagion, and if you got it, the red spots appeared first on your face, hands and forearms, and later on your trunk. In fact, the origin of smallpox was one kind of powerful natural disease
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that was lost in prehistory (Stefan Riedel, 2005). It means smallpox appeared early, and it affected people’s life a long time ago. However, people were not real aware of smallpox disease until they discovered smallpox vaccine. According to research by Stefan Riedel (2005), the only way to prevent smallpox is smallpox vaccine that was discovered by Dr. Edward Jenner in the late 18th century in Europe. It shows that people had been finding a method to prevent smallpox disease for several decades ago, and they began to research and treat smallpox. Thus, smallpox vaccine was discovered, that people were improved immunity by smallpox disease physically and mentally. Cause One cause of smallpox disease is a new virus into the human body. When this virus came to your body, it could live in everywhere and seem like to seed in your body. Smallpox is caused by a poxvirus called variola that contains double-stranded DNA (MedicineNet, 2015). It shows the variola could be easy to live because it had owner double-stranded DNA, and it didn’t need parasitism to another sell. Another cause of smallpox is infectious ways that are too many and direct. A poxvirus can transit in the goods and air to spread another person. According to research by San Francisco Department of Public Health (n.d.), smallpox virus often rely on contact, coughing, sneezing, and talking to spread from an infected person to another person. This means the smallpox virus can be spread easily and fast in people’s live. In addition, some social problems can expedite transmission of poxvirus such as population crisis. In the article “Edward Jenner and and the history of smallpox and vaccination,” Stefan Riedel (2005) mentioned smallpox appeared in Americas because many slaves came from regions in Africa where smallpox was endemic. This shows the slave trade is one of factor that cause smallpox virus spread rapidly. Effect Smallpox affects people’s live. It was one of the most devastating diseases known to humanity in the world, and it caused over a million deaths. Smallpox killed too many people in history, so people never forgot that smallpox killed their friends or families. About 300 million to 500 million deaths from smallpox worldwide during the 20th century, and people who got smallpox disease could be blindness (MedicineNet, 2015). It shows that smallpox disease was terrified, and when people got smallpox virus, they could be die or . Indeed, they didn’t know what they should have done to prevent it, and they only accepted or suffered a result of death. According to research by Stefan Riedel (2005), smallpox was one of the reasons that caused the Roman Empire to die out. It also stated that smallpox is so powerful. We know Roman armies were very powerful, but they couldn’t defeat smallpox disease. It destroyed the powerful Roman Empire. On the other hand, smallpox existed a long time ago to kill people. Smallpox has been a scourge against humanity for at least the past 1500 years, and perhaps much longer than that. (Edward & Allison, 2003). This means we can’t count how many people died because of smallpox in the past 1500 ago. It must have been a lot of deaths. According to the article “A Look at Each Vaccine: Smallpox Vaccine” by Paul A. Offit (2014), smallpox has probably killed more people in the history of the world than all other infectious diseases combined. It also shows smallpox disease killed too many people. However, smallpox not only affects people’s lives, but it can also appear in military. Because of the powerful smallpox disease, some people might generate a strong desire, that they want to control it to make the scary biochemical Weapon. After 911— the attack on the World Trade Center on September 11, 2001, smallpox has been identified agent of bioterrorism (Riedel, 2005). This event made the governments to pay more attention to the smallpox virus. In addition, smallpox is one kind of infectious disease. When it appears in developing countries which have a large population crisis, smallpox seems like a nuclear weapon. At the moment, smallpox could kill over a million people. In addition, many countries use the smallpox virus in the war. The devastating effects of smallpox have become a biological warfare—“ During the French and Indian War using smallpox diminished American Indian population hostile to the British ” (Riedel, 2005). In other words, people began to use the smallpox virus to create the war, and killed more and more people. Solution—Development of smallpox vaccine Now, smallpox is already becoming historical disease because we are successful to find a smallpox vaccine that can prevent smallpox virus.
The smallpox vaccine can protect people that is only way to prevent smallpox vaccine. In the article “ Smallpox Vaccine,” by FamilyDoctor (2012) stated that the smallpox vaccine was used to wipe out smallpox disease until the early 1970s in the world, and it much like other vaccines can protects people against infection by helping their body develop immunity to the smallpox virus. It shows the smallpox vaccine is a more effective method to prevent smallpox disease. Besides, people can get smallpox vaccine easily, and they can save it. According to research by World Health Organization (2014), the vaccinia virus is remarkably stable because it stored under appropriate conditions for as long as 18 years have not lost their potency. Therefore, the governments or some international organizations can save a lot of smallpox
vaccines. Problem The smallpox vaccine is not without some risks that has many limits and defects. The first risk is that not all people can get smallpox vaccines. Some specific throngs should not get the vaccine such as pregnant women, children younger than 12 months of ago, and people with weakened immune systems (CDC, 2007). This limits cause the specific throngs get smallpox virus easily because they all have a weaker immune system. Another risk is that the vaccine has many side effect, but the severe side effects following administration of the smallpox vaccine do occur are relatively uncommon. About two of every 10,000 people might get the vaccine will develop a generalized rash that spreads to the body, and about one of every 100,000 people who get the smallpox vaccine will develop an infection of their brain(Cleveland Clinic, n.d.). This shows the vaccine has a obvious risk even though it is uncommon. Conclusion Smallpox disease is not terrified, but the terrified thing is that people give up to find a way of treatment to prevent disease and understand disease. Therefore, we should have known some powerful disease such as smallpox that had effect and cause many people. Also, I hope this essay can help people understand smallpox disease. When we face a new disease that seems like smallpox, we can find the same way to research or overcome it. We can avoid waste of time in ignorance for a new disease.
Faith in religion had fallen because the prayers of the people were not answered. The people even thought that it was god whom had unleashed this deadly disease. One piece of evidence that I used stated,” Some felt that the wrath of God was descending upon man, and so fought the plague with player (Document 6).” Another piece of evidence stated,” Faith in religion decreased after the plague, both because of the death of so many of the clergy and because of the failure of prayer to prevent sickness and death (Document 6).”
Many wondered what the true cause of the Black Plague was and how it spread all across the world in such a short amount of time. Throughout its time period, many medical authorities and scientists sought to give rational explanations for the reasons why the plague was spreading and believed it was caused by several factors such as: “corrupted air and water, hot and humid southerly winds, proximity of swamps, lack of purifying sunshine, excrement and other filth, putrid decomposition of dead bodies, excessive indulgence in foods (particularly fruits), God's wrath, punishment for sins, and the conjunction of stars and planets” (Encyclopedia of Plague and Pestilence). The confusion and lack of scientific knowledge on the harmful disease caused much panic and triggered many outbreaks among individuals. Many people began to start placing cities and ships under quarantine, burning sulfur to purify bad air, burning clothes, and even blaming and killing Jews in hope that they could solve a cure or at least stop the spread.
We can see this as we compare the writings of Weyer, (document 4) from the fifteenth century, who feared the Plague, to the writings of Bertrand, (document 16) from the eighteenth as he declared the Plague was cause because of religious superstition. This shift in belief may be caused by the "Age of Enlightenment" that caused people to think more irrationality, and to heavily believe in
During the fourteenth century, bacteria and viruses were mostly unknown to doctors, which meant they were most certainly unheard of for the majority of the population. Now, it is widely believed that it was caused by bacterial strains. Back then, however, people had to produce their own reasons for the Plague. In Europe, the causes of the Black Death were said to be miasma (impure air) carried by the warm southern winds. The event of March 20, 1345, the conjunction of Saturn, Jupiter, and Mars, and excessively atrocious clothing were thought to add to the ubiquitous disease. In contrast, the people near the East believed that the said disease was supposedly caused by miasma as well, but due to wind carrying the vile odor of Mongol bodies...
An important fact to remember is that in those times, opinions and actions were either based on or blamed on religion and superstition. For example, people started marching across the country, punishing themselves on the basis that the plague was the result of all of man’s sin, whilst trying to persuade people of their cause. Also, charms were used by some cultures, such as the “Abra Kadabra” charm, which was either carved, or worn as protective jewellery to ward off the evil spirits causing the plague. It looked similar to the image below.
The outburst spread of diseases in a population causes people to panic and become hopeless. The main reason diseases spread is due to unsanitary living styles. Also when a disease first begins, it is really hard to find a cure right away. A very deadly, infectious disease known as Typhus spread during the Holocaust. Typhus is caused by rickettsia and is spread by lice and flees.
Orthopoxvirus variola is the virus responsible for the well-known smallpox disease. It belongs to the Poxviridae family which is further split into the subfamilies Entomopoxivirinae which only affects insects, and Chordopoxivirinae which infects vertebrae (Hughes). It is in group one of the Baltimore Classification since it possesses double-stranded DNA. This group also includes viruses in the Herpesviridae family, certain bacteriophages, as well as the mimivirus. The linear genome consists of approximately 186 kb pair and, like all orthopoxviruses, is about 200 nm in diameter (Li; Riedel). Virus particles may be enveloped, but the majority will be nonenveloped when released from a lysed cell, ready and capable to affect another. Extracellular enveloped viruses evolve from their precursors intracellular enveloped virus and cell-associated enveloped virus and contain proteins that aid the virus in neutralizing host cell antibodies to enhance virus spread (Smith). Entrance into the host cell may be accomplished by fusion of endocytosis, contingent on the particular strain. Host cell cytoplasm is the site of poxvirus replication, therefore host nuclear enzymes are unavailable to the virus; to overcome this, DNA-dependent RNA polymerase enters the host with the virus (Hughes).
The perspective the author gives to this book is a unique. Smallpox according to most histories does not play the role of a major character, but a minor part. In my opinion smallpox was a major factor during the Revolutionary War, and Feen focuses on several key areas which allows us to see just how bad this epidemic was and the grip it had not only on the soldiers, but the colonist as well.
Since Plagues and Peoples covers several subjects of knowledge, he helps the reader understand key concepts by fully explaining parasitism and its dependence on humans and animals. People in the field of history, which make up a majority of this books audience, would need more insight into epidemiology to grasp its key concepts. It would not be likely for a historian to be knowledgeable in a branch of medical science that deals with the incidence, distribution, and control of disease in populations.
Vaccines have been used to prevent diseases for centuries, and have saved countless lives of children and adults. The smallpox vaccine was invented as early as 1796, and since then the use of vaccines has continued to protect us from countless life threatening diseases such as polio, measles, and pertussis. The Center for Disease Control and Prevention (2010) assures that vaccines are extensively tested by scientist to make sure they are effective and safe, and must receive the approval of the Food and Drug Administration before being used. “Perhaps the greatest success story in public health is the reduction of infectious diseases due to the use of vaccines” (CDC, 2010). Routine immunization has eliminated smallpox from the globe and led to the near removal of wild polio virus. Vaccines have reduced some preventable infectious diseases to an all-time low, and now few people experience the devastating effects of measles, pertussis, and other illnesses.
Smallpox is a highly infectious and fatal disease caused by the Variola virus. It causes extremely painful pustules to sprout across the entire body. Spread from human to human, it has since been eradicated from the world through the efforts of the World Health Organization. However, there is a distinct possibility that it may be reintroduced through bioterrorism. Biological weapons may cause another pandemic to erupt across the world and kill millions of individuals. Through constant vigilance and careful planning, mankind can prevent this scenario.
Native Americans never came in contact with diseases that developed in the Old World because they were separated from Asia, Africa, and Europe when ocean levels rose following the end of the last Ice Age. Diseases like smallpox, measles, pneumonia, influenza, and malaria were unknown to the Native Americans until the Europeans brought these diseases over time to them. This triggered the largest population decline in all recorded history. Fifty percent of the Native American population had died of disease within twenty years. Soon after, Native Americans began to question their religion and doubted the ability of shamen to heal. This was the first step towards the destruction of Native cultures. The Native Americans had never experienced anything like these deadly diseases before and they came to believe that Europeans had the power to kill or give life.
Vaccinations are a particular type of disease preventer with a lot flaws. Vaccines should be non-compulsory. people should have a choice if they want to inject their children with an inactive disease that's up to them. No medicine is perfect most of the time vaccines have had a positive outcome on the majority of the world’s population that have had vaccines. Although the percentage of incidents are low they can still be serious. People say vaccines can lead to autism and other symptoms.
Illness has been a major part of humankind’s lives almost since the beginning of time. Throughout history, illnesses caused fatal epidemics that caused deaths between young and old, and brought fear upon all for the absence of a cure. Having an illness throughout most of history was considered an inevitable death sentence, as the majority of causes of death (Offit). Vaccinations have been experimented in China and Turkey in the 15th century, with methods such as inhaling or rubbing grounded up smallpox scabs against open cuts (Clem). Then in 1700s, the first form of modern vaccination was invented by Edward Jenner with the cowpox virus acting against smallpox, giving immunity against it (Offit).
The history of smallpox goes back for thousands of years. It is thought to have appeared as much as 10,000 years ago and since then, it has claimed the lives of millions of people, many of whom have been famous figures in history. After a vaccine was discovered in 1796, countries throughout the world began the fight to eradicate the disease. This fight was won in 1980 as a result of the international effort headed by the World Health Organization. Today, smallpox is no longer a threat in nature but the virus is still stored in labs, from which a biological weapon could be made.