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An Overview Of Sickle Cell Disease
Abstract for sickle cell anemia
An Overview Of Sickle Cell Disease
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Sickle Cell Disease is a condition where there is not enough healthy red blood cells to carry oxygen throughout the body. Another name for sickle cell disease is sickle cell anemia. Sickle cell anemia is inherited as a simple recessive condition. In normal red blood cells, the cells are usually flexible and round. However, in sickle cell disease the red cells become rigid and sticky. They are shaped like sickles or crescent moons. Because these cells are irregular, they can get stuck in small blood vessels. The small blood vessels slow or block blood flow. Without enough red blood cells in circulation a person's body cannot get the adequate amounts of oxygen needed to feel energized. There are many signs and symptoms of sickle cell anemia. The sickle cell disease usually shows up after an infant is approximately four months old. Anemia is one sign of sickle cell disease. Red blood cells usually live for 120 days before they need to be replaced by new ones. However, sickle cells die off after ten to twenty days. Another symptom of sickle cell anemia is episodes of pain. Episodes of pain are one of the major symptoms of sickle cell anemia. The pain develops because sickle-shaped red blood cells block the flow through tiny blood vessels to your abdomen, joints, and chest. These episodes of pain that occur periodically are called crises. Some patients diagnosed with sickle cell anemia only experience pain a few times in a year, whereas; others can experience various amounts of crises a year. Sometimes if the pain is severe patients may be hospitalized. The pain can also occur in the bones as well. To continue, hand-foot syndrome is also another symptom of sickle cell anemia. Usually a patient will have swollen hands and feet. The s... ... middle of paper ... ...ficance by the World Health Organization. To continue, 70 percent of sufferers of sickle cell disease live in Africa. Sickle cell disease is found more commonly in people who are descendants from the Middle Eastern, Indian, Mediterranean, and African heritages. This is because those geographic regions are most prone to malaria. The gene variant for SCD is related to malaria. Therefore, wherever malaria occurs there is sickle cell disease. It is also believed that people who carry the sickle cell trait are less likely to have severe forms of malaria. It is estimated that sickle cell disease will affect 90,000 to 100,000 American. Sickle cell disease affects a large percentage of people in Central America as well as significant numbers in South America such as Brazil, and the Caribbean. Sickle cell disease is the most frequently occurring genetic disease on the earth.
Symptoms of a sickle cell are shortness of breath or fatigue and delayed growth in the development of children. Severe pain can be caused as a symptom when the blood gets stopped up in the vessel and causes the patient 's heart to pump slower, so people begin to feel pain in the body and feel out of breath.
SCD has major social and economic implications for the affected child and the families. Recurrent sickle-cell crises interfere with the patient’s life, especially with regard to education, work and psychosocial development (WHO). Sickle cell anemia, specifically, is a serious disease that can require frequent hospital stays. Repeated hospitalization for intravenous pain medication, antibiotic therapy and blood transfusions is undertaken to treat medical problems as about 1 in every 10 children with sickle cell disease. People with SCD may suffer abdominal pain, breathlessness, delayed growth and puberty, fatigue, fever, ulcers, among others. These patients often die early of overwhelming infection or as a consequence of acute or chronic damage to the body organs. Those with sickle cell disorder often suffer neglect and
Stem cells help us to maintain and heal our bodies, as they are undifferentiated cells, their roles are not yet determined. They have the ability to become anything during early life and growth. Stem cells come from two sources, namely: embryonic stem cells (embryo’s formed during the blastocyst phase of embryological development) and adult stem cells (see figure 3).
Thalassemia is an inherited blood disorder characterized by low amounts of hemoglobin and a low count of erythrocytes in the body. Thalassemia is caused by mutations in the deoxyribonucleic acid of cells, which makes hemoglobin. The mutations are passed from parent to child. The mutations vary depending on the type of Thalassemia inherited. The variation in the mutation occurs from the number of gene mutations, which are inherited, as well as mutation within the hemoglobin molecule. Clinical manifestations are diverse ranging from asymptomatic, to those who are carriers of the thalassemia, which may have mild symptoms, there also people who posses the trait, who may have severe symptoms which lead to death.
During a short break of solitude from studying, I explored and came across that the environment in which most African Americans reside in has a high occurrence of malaria virus. The malaria virus disease is contagious and when it contaminates someone with sickle cell traits, it cannot survive on the external part of the human body so therefore the individual doesn’t develop the deadly malaria virus. While looking further into our class textbook on Human Genetics 11th Edition by Ricki Lewis, and this issue of sickle-cell among the African Americans, I
Unlike normal red blood cells that last about 4 months in the bloodstream, fragile sickle cells break down after only about 10 to 20 days, which usually causes anemia. Anemia (pronounced: uh-nee-mee-uh) is what happens when the body's number of red blood cells (or amount of hemoglobin) falls below normal. People who are anemic often feel weak and tire more easily.
Sickle cell was first discovered by Dr. Ernest irons that was a hospital intern who look over a patients cell which seem to be different he called them “sickle cell shaped”. Sickle cell is know as a negro inherited diseases which is incorrect not only African Americans have this diseases. Many other races are effect by this diseases and regions all over the world such as India, Mediterranean countries, South American. In this case sickle disease work kind of like vaccination for malaria another diseases, this is the most common inherited disease in American. Anyone who has sickle trait and have a baby with someone who has the trait also can bring a baby into the world the world with SCD.
“The word 'leukemia' is a very frightening word. In many instances, it's a killer and it's something that you have to deal with in a very serious and determined way if you're going to beat it” - Kareem Abdul-Jabbar. Many people, including tons of children, fight leukemia every day trying to beat this vicious cancer. Without knowing how leukemia is exactly caused, it puts a damper on how to avoid it.
Sickle cell disease can be very discomforting and painful for those who suffer with the symptoms that it brings interrupting the lives of patients. Even though sickle cell disease has no cure it can still be managed to where the patient can live a comfortable life.
Sickle cell anemia is a disease that reforms the patient’s red blood cells, which makes the red blood cells has an abnormal shape like a sickle. Sickled red blood cells can result to severe anemia; decrease causes numerous painful symptoms in patients. A defective protein called hemoglobin is what cause the abnormal shape of the red blood cells in the sickle cell patients.
Sickle Cell is a disease that affects many people in the world today. It is the number one genetic disorder in the United States. Sickle Cell is deficient hemoglobin. Hemoglobin is what functions in providing oxygen to the cells in the body. The sickle shape comes from the atypical hemoglobin s molecules. Hemoglobin molecules are composed of two different parts called the alpha and beta. The beta subunit of the hemoglobin molecule has a mutation in gene, on chromosome 11 which produces the change in the red blood cell shape causing them to die and not reproduce accurately. The change in shape causes the red blood cells to get stuck in the blood vessels and block the effectiveness of oxygen transport causing pain and organ damage to the body. This disease does not have a cure and some common treatments are used to help patients live with the disease. Some treatment options are antibiotics (penicillin) to prevent infections, blood transfusions, folic acid that help produces new blood cells. These are just some of the current treatments for Sickle Cell.
Sickle Cell Disease is inherited from parent to offspring. In the last counseling session, I mentioned that the disease is caused by the mutation in chromosome 11. This mutation does not occur randomly. The mutation first occurred thousands of years ago, and ever since then, the select few offsprings of the person that first received the mutation have inherited the mutated gene (controls inherited traits).
The purpose of this essay is to tell how has malaria affected people that have sickle cell and is sickle cell common in places malaria is common, and how it correlates with each other? Malaria and sickle cell allele have a direct correlation on how many countries have malaria versus people with the HbS allele because, HbS allele is affected by the presence and absence of malaria, the effect malaria has on people with the HbS allele, and technological advancements.
Sickle cell anemia is a genetically linked disorder were the red blood cells do not form properly and may cause problems due to their abnormal shape. The symptoms for sickle cell anemia is similar to other types of anemia, which may include lethargy, shortness of breath during light exercise, or dizziness and lightheadedness when active. Additionally, sickle cell sufferers may form dangerous blood clots in their veins. Although blood clots in remain in the circulatory system without causing problems for years, the blood clot may one day block a major artery in the heart or brain, which may lead to permanent organ damage or death. Fortunately, sickle cell can be tested for and does not need to be diagnosed by its symptoms. The best test for
Thalassemia is a blood disorder transferred through families. It occurs when the body makes less hemoglobin than needed or an unusual form of hemoglobin. Hemoglobin is the protein in red blood cells that carry oxygen. The disorder makes an excessive amount of destruction of red blood cells. This eventually leads to anemia.