The cause of acute, persistent, or relapsing clinical infections is often due to multidrug resistance and/or antibiotic tolerance. Pseudomonas aeruginosa is a widespread, opportunistic, gram-negative, bacterial pathogen that readily develops multidrug resistance and is responsible for causing acute and persistent infections (Starkey et al, 2014). P. aeruginosa thrives in moist environments, primarily as waterborne and soil-borne organisms (Chen, 2015). It is found on medical equipment including catheters, which can cause cross-infections in hospitals and lead to nosocomial infections. If P. aeruginosa is found in the lungs, the urinary tract, or the kidneys, the results can be fatal (Chen, 2015). In addition to causing life-threatening diseases, …show more content…
Quorum sensing is a cell-to-cell density dependent communication system mediated via the production of and regulation by low molecular weight signaling molecules (Starkey et al, 2014). Quorum sensing is crucial for the development of biofilms, which aid in the maintenance and antibiotic tolerance of acute and persistent human infections. P. aeruginosa has three distinct quorum sensing systems mediated by cell-to-cell signals including the las, rhl, and mvfR system (Starkey et al 2014). In this study they targeted the bacterial communication system mvfR, which is essential to the full virulence of P. aeruginosa. MvfR binds to and activates the pqs operon, which encodes for the synthesis of PQS, HHQ and 2-AA. Both PQS and HHQ bind to and activate mvfR, which leads to the production of mvfR virulence factors that promote acute and persistent infections. By identifying quorum sensing inhibitors, they were able to inhibit the mvfR virulence regulon, which disrupted cell-to-cell communication and limited P. aeruginosa infections and lethality in mice. These inhibitors are the first identified compounds that restrict the formation of antibiotic-tolerant persister cells and restrict persistent infections in mice (Starkey et al,
Adam Smith’s moral theory explains that there is an “impartial spectator” inside each of us that aids in determining what is morally and universally good, using our personal experiences and human commonalities. In order to judge our own actions, we judge and observe the actions of others, at the same time observing their judgments of us. Our impartial spectator efficiently allows us to take on two perceptions at once: one is our own, determined by self-interest, and the other is an imaginary observer. This paper will analyze the impartiality of the impartial spectator, by analyzing how humans are motivated by self-interest.
In the documentary, Hunting the Nightmare Bacteria, reporter David Hoffman investigates this new untreatable infection along two individuals and a bacterial virus within a hospital. The first individual Hoffman investigates is Addie Rerecich of Arizona, she was treated for a staph infection with antibiotics, but other complications arise. Addie had a lung transplant, she was given several different antibiotics, but her body became pan-bacteria, non-resistance to the bacteria. Addie’s life was on the edge, she had to be on life support, and finally she received new lungs. The transplant helped Addie but it would take years before could go back to normal before the infection. The second individual is David Ricci; he had his leg amputated in India after a train accident. The antibiotic treatment he received became toxic to his body increasing problems. While in India, he underwent surgery almost every day because of infections he was developing. Back in Seattle, doctors found the NDM-1 resistance gene in his body; NDM-1 gene is resistance to almost all antib...
However, increasing antibiotic resistance patterns among intensive care unit pathogens, cultivated by empiric-broad spectrum antibiotic regimens, characterizes the variable concerns. Recent literature point that antibiotic use before the development of VAP is associated with increased risk for potentially resistant gran-negative infections and Methcillin-resistant Staphylococcus auereus (MRSA)
Bacterial resistance to antibiotics has presented many problems in our society, including an increased chance of fatality due to infections that could have otherwise been treated with success. Antibiotics are used to treat bacterial infections, but overexposure to these drugs give the bacteria more opportunities to mutate, forming resistant strains. Through natural selection, those few mutated bacteria are able to survive treatments of antibiotics and then pass on their genes to other bacterial cells through lateral gene transfer (Zhaxybayeva, 2011). Once resistance builds in one patient, it is possible for the strain to be transmitted to others through improper hygiene and failure to isolate patients in hospitals.
Pseudomonas aeruginosa (P. aeruginosa) is a gram-negative, rod-shaped aerobic bacterium. It is a primary cause of hospital-acquired infections. P. aeruginosa is primarily a nosocomial pathogen. It also acts as an opportunistic pathogen, which can only infect a host that is immunocompromised, due to an underlying disease or medication. Although, P. aeruginosa can cause damage to virtually any tissue in the body, it almost never affects the tissues of healthy individuals. It is a problematic pathogen in hospitals; infecting individuals with cancer, burn wound, catheters and cystic fibrosis. P. aeruginosa is most recognized for its resistance to a wide range of antibiotics. In its planktonic form, P. aeruginosa has been found to have many virulence factors. However, P. aeruginosa within biofilms have been found to have a resistance to antibiotics 1,000 times greater than that of its planktonic counterparts [4]. Infections that are caused by bacterial biofilms are very persistent and very difficult to treat.
It is undeniable that the recent discovery of antibiotics and disinfectants in the past century is leading to the creation of increasingly dangerous antibiotic-resistant bacteria. Super bugs like Methicillin-resistant Staphylococcus have begun breaking out in hospital areas, killing more and more patients due to the lack of people following through with simple safety measures. In order to stop the creation and spread of antibiotic-resistant super bugs, proper precautions must be taken such as avoiding antibacterial cleaners, following through with instructions when taking prescriptions and maintaining adequate hand hygiene. Through adhering to basic safety rules, the creation and spread of super bugs can be minimized and all together discontinued from occurring at such a rapid rate.
The Pros and Cons of Tracking Devices. What is this world coming to? When most of us think of tracking devices, they think of primarily negative issues. But that has all changed now.
There are eight categories of verbal communication that are classified under the system of Group Development Observation System (Griffith & Dunham, 2015). The Group Development Observation System was developed to categorize verbal interactions within a group (Griffith & Dunham, 2015). The eight categories that can be used for classification are dependency statements, counterdependency statements, fight statements, flight statements, pairing statements, counterpairing statements, work statements, and unscorable statements (Griffith & Dunham, 2015). Dependency statements identify the dominant group mood (Griffith & Dunham, 2015). They also solicit direction (Griffith & Dunham, 2015). Counterdependency statements identify independence amongst
Streptococcus pneumoniae is a Gram-positive and fast-growing bacteria which inhabit upper respiratory tract in humans. Moreover, it is an aerotolerant anaerobe and usually causes respiratory diseases including pneumonia, otitis media, meningitis, peritonitis, paranasal sinusitis, septic arthritis, and osteomyelitis (Todar, 2003). According to Tettelin et al., more than 3 million of children die from meningitis or pneumonia worldwide (2001). S.pneumoniae has an enzyme known as autolysin that is responsible for disintegration and disruption of epithelial cells. Furthermore, S.pneumoniae has many essential virulence factors like capsule which is made up of polysaccharides that avoids complement C3b opsonization of cells by phagocytes. Many vaccines contain different capsular antigens which were isolated from various strains (Todar, 2003). There are plenty of S.pneumoniae strains that developed resistance to most popular antibiotics like macrolides, fluoroquinolones, and penicillin since 1990 (Tettelin et al., 2001). Antibiotic resistance was developed by the gene mutation and selection processes that, as a consequence, lead to the formation of penicillin-binding proteins, etc. (Todar, 2003).
In Their Eyes Were Watching God, Hurston uses the mule as a symbol representing the mistreatment of black women in this time period. Mules are typically thought of as stubborn, inexpensive animals used primarily for work which is parallel to how society viewed black women during this time. When Janie is opposing Nanny’s suggestion to marry Logan Killicks, Nanny tells her the black woman is the mule of the world (Hurston 14). Nanny’s comparison implies that a colored woman is the lowest creature around, and Janie should submit to Logan’s guidelines. Just as a mule would, Janie remains stubborn and independent through this “arranged” marriage and works hard to reduce the restraints set by her husband. When Logan goes to
The Evolution of Antibiotic Resistant Bacteria. Since antibiotics, such as penicillin, became widely available in the 1940s, they have been called miracle drugs. They have been able to eliminate bacteria without significantly harming the other cells of the host. Now with each passing year, bacteria that are immune to antibiotics have become more and more common.
Bacteria are found nearly everywhere within the body and most types are harmless or even helpful to bodily function (Novitt-Moreno). While it is important to have these bacteria in the body, pathogenic invaders can cause serious illnesses. Pathogenic bacteria work by either actually attacking a part of the victim’s body or releasing toxic waste products into the body. Bacteria are single-celled and contain all of the cellular mechanisms needed to live, grow, and reproduce (Novitt-Moreno). That means, when treating a bacterial infection, it is critical to have a highly specific antibiotic that can destroy the unwanted
Hospital acquired infections are spread by numerous routes including contact, intravenous routes, air, water, oral routes, and through surgery. The most common types of infections in hospitals include urinary tract infections (32%), surgical site infections (22%), pneumonia (15%), and bloodstream infections (14%). ( book). The most common microorganisms associated with the types of infections are Esherichila coli, Enterococcus species, Staphylococcus auerus, Coagulase-negative staphylococci, or Pseudomonas aeruginosa.(secondary) Urinary tract infections occur when one or more of microorganisms enter the urinary system and affect the bladder and/or the kidneys. These infections are often associated improper catheterization technique. Surgical site infections occur after surgery in the part of the body where the surgery took place. These infections may involve the top of the skin, the tissue under the skin, organs, or blood vessels. Surgical site infections sometimes take days or months after surgery to develop. The infections can be cause by improper hand washing, dressing change technique, or improper surgery procedure. Pneumonia can also become a hospital acquired infection. Ventilator-associated pneumonia is a type of lung in...
Based on the small group that I joined in communication class, I will talk about what is working well and what is getting in the way in our group. Then I will discuss about what I can do to improve the group and the things about group project if there is a chance for a start over again. At last, I am also going to talk about what I think that I learned is an important lesson in this semester.
Exposure to antimicrobials fundamentally alters microbial ecosystems of humans, animals and the environment, which may lead to the development of antimicrobial resistance.