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The Placebo Effect
The activity I chose to write about was on Dr. Walter A. Brown’s article in Scientific American about placebos and their effect on the patients. His article described what a placebo is and if it is ethical for doctors to prescribe this “treatment'; to their patients.
Dr. Brown, who is a psychologist at Brown University, decided to do a study on the effects of a placebo. A placebo is any treatment or drug with no medicinal value that is given to a patient to relieve symptoms of an ailment. His hypothesis in the article focused on if the placebos had any effect on the patients who took them.
To test his hypothesis, Dr. Brown and his colleagues performed experiments on patients who had depression. To test his idea, he employed what is known as the “double blind technique.'; This type of experimentation involves that neither the doctors nor the patients know if they are receiving the real “stuff'; or simply sugar pills (placebos). Only the experimenters know who gets what. What this supposedly does is that the patient will mentally think that the doctor is giving him/her the real drug and they will soon be feeling better. When in reality, it is themselves, not the medicine, which makes them feel better. These are the findings of Dr. Brown.
In his experiments on the placebos, he found that the placebo can make a person feel better, but it can also have no effect what-so-ever. In his study of the depressed patients, about 50% of the subjects with normal levels of cortisone benefited from the placebo, whereas, only about 35% of the depressed patients benefited from the drug. This led Dr. Brown to realize that there are other factors in treating depression. He found that the persons with short-term depression responded more favorably to the placebo than those with long-term depression.
Other doctors also performed “placebo experiments'; to realize if it really works. One example would be of the experiments led by Edmunds G. Diamond of the University of Kansas Medical Center in the 1950’s. His research involved the surgery to treat angina pectoris. He had a set of 18 patients suffering from this ailment have common surgery to relieve this symptom. In 13 of the patients, the doctors actually performed the operation, however in the other five, all they did was make an incision in the chest and sew it back up.
But one may wonder when DPB is necessary and what the benefits of such practice are. Cullen and Klein state that “this deception-to-benefit-the-patient view has a prima facie (at first glance) appeal,” although some may argue that this line of thinking has not yet been proven with positive results. One illustration to this theory is when a doctor tells a kidney transplant recipient that he is doing good and that the prognosis looks promising with the justification that the patient, although the kidney is not functioning at all, but after hearing the positive feedback from the physician, it may lift his spirit and regain full health. The physicians with this type of ideology presume that “a sick person isn’t made better by gloomy assessments.” This type of DBP is intended to be used in order to benefit the patient, however, there are no proven cases to confirm that this method works, and it’s merely intended as an effort for the physicians to make the patient feel better, furthermore, as stated by Cullen and Klein “In all but rarest cases, deceiving a patient ‘for his own good’ is an unacceptable way for a physician to try to help her patient.” (Cullen & Klein
In Marcia Angell’s article, “The Ethics of Clinical Research in the Third World,” she strongly argues the use of clinical placebo-controlled trials done in developing countries are unethical if an effective treatment already exists. Angell believes studies that compare potential new treatment with a placebo controlled group is ineffective and unnecessary. All research studies should offer the best standard of care and give participants the most beneficial outcome and treatment possible. The main priority of a study is not the goals of the research itself, but the well-being of the participants. Angell uses many sources to defend her argument, such as WHO.
The first part will also draw upon Chapter 3 of, “Fundamentals of Social Research,” and will compare Doctor Money’s research with against ethical agreements and standards that prevail in Social
When and why do you think the subject in the experiment began to "second guess" himself?
Ernst, E., & Resch, K. L. (1995). Concept of true and perceived placebo effects. British Medical
Antidepressant are a form of pharmacotherapy treatment developed to treat the symptoms of major depression. Antidepressants are used for many other types of conditions including anxiety disorders, obsessive compulsive disorder, dysthymia, eating disorders, sleeping disorders, and substance abuse, pain syndromes, gastrointestional disorders. Antidepressants usually require several weeks to notice significant effects. There are no antidepressants or any medication that is completely free of adverse effects. This article explains that the adverse effects of antidepressant can decrease compliance and slow down the rate of recovery. It is important for one to take note of potential side-effects before choosing the best antidepressant to suit their personalized needs. Statistics show that about 28 percent of patients sto...
In his book, Meyers recounts the stories of numerous scientists and researchers who discovered something magnificent when merely looking for something else. This is not to say that all of the scientists did something wrong in their research, but Meyers argues that the beauty of serendipity in medical discoveries is that no matter where the discoveries come from or how they come about, all it takes is someone intelligent and creative enough to understand the true application of the discovery. Meyers writes about four different categories of discoveries in his book. The first category is full of historical medical discoveries mostly focusing on diseases and antibiotics. The second and most relevant category is about the numerous advancements in cancer treatment. The third category focuses on one major organ: the heart which requires major focus in modern American healthcare. The fourth and last category discusses different psychotropic drugs that have been discovered as well as their uses in medicine. One of the most interesting discoveries that Meyers discusses is written within the second
Article two entitled “Clinical trials: are they ethical?” is written by Eugene Passamani discusses the importance of randomized clinical trials. Passamani rejects the argument that the physician-patient relationship demands that physicians recommend ...
The first major study conducted on the matter in the United states found that St John’s wort had negligible benefits on patients with major depression with no statistically significant benefits more then those produced by a placebo (Shelton). However other studies have “proved”, not only that St. John’s Wort is more successful in treatment of patients with depression, but that It is actually similarly or more effective than some tri-cyclic prescription antidepressants (Linde). The apparent contradictions in research findings are confusing and provide little help to a patient or doctor in deciding whether to use St John’s Wort as a treatment for depression.
...reatly increased, and the results in treating disorders such as depression have become more dramatically positive (Gross 1). Unlike technology, chemicals such as those found in antidepressants cannot be easily altered. Complex biological processes often have to take place, and testing must be done on animals with each new chemical manipulation. This takes time and money, where adjusting rTMS methods is fairly simple and inexpensive to the medical industry.
Schmied, L. A., Steinberg, H., & Sykes, E. A. B. (2006). Psychopharmacology's debt to experimental psychology. History of Psychology, 9, 144-157.
Introduction: For my research project I would like to explore the effectiveness of antidepressant drugs. Antidepressant drugs are used are used to treat major depression and other conditions, some of which include anxiety, obsessive compulsive disorder, chronic pain and other disorders. Around the world antidepressants are used to cure these types of mental illnesses. It is argued by both medical professionals and other people whether or not they believe that antidepressants work. According to Mayo Clinic one in ten Americans take an antidepressant. Today, antidepressants have became the most common way around the world to treat major depression
Depression can result from a physical disease, a mental illness, or it can be a recurring reaction of the body. According to the National Institute of Mental Health, major depressive illnesses are often the result of imbalances in neurotransmitters in the brain. It is these critical chemicals that send messages between nerve fibers and control mood (Creamer, 3). Older anti-depressants worked on three different neurotransmitters, serotonin, norepinepherine, and dopamine. However, it has been found that serotonin is the specific chemical in the brain that controls moods. Its job is to carry an impulse from one nerve fiber to the next. Serotonin is released by the nerve into the space between nerve fib...
Throughout centuries medical research has been conducted on animals. “Animals were used in early studies to discover how blood circulates through the body, the effect of anesthesia, and the relationship between bacteria and disease” (AMA 59). Experiments such as these seem to be outdated and actually are by today’s means, scientists now study commonly for three general purposes: (1) biomedical and behavioral research, (2) education, (3) drug and product testing (AMA 60). These three types of experiments allow scientists to gain vast amounts of knowledge about human b...