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Warfare was the most significant factor in the development of penicillin
Alexander fleming and antibiotics
Research paper on penicillin
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Penicillin, an antibiotic agent, helps cure many people of infectious diseases. It was one of the first antibiotics discovered and continues to save many lives. Penicillin played a vital role in medicine throughout history and still does today. Many important events led to the discovery, early development, and later development of penicillin, along with the help of scientists Alexander Fleming, Howard Florey, and Andrew J. Moyer.
The discovery of penicillin, in 1928, was purely by accident. It was discovered by bacteriologist Alexander Fleming when he came back from vacation to his lab in London. He had left his lab in a mess and found that mold had grown on some plates he had left out in the open. Fleming noticed one plate in particular that had a ring around the mold. “After some experimentation, he found that the ring was bacteria-free, and that the mold was a rare spore called Penicillium notatum…” (Lane). Fleming grew the mold and discovered that it created a substance that had the property of killing many disease-causing bacteria. He named this substance penicillin and published his findings, noting that it may have value if produced in quantity
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Howard Florey, a scientist at the Oxford University. Florey, along with some of his colleagues, began research on penicillin and its properties in 1939. They brought a small dose of penicillin to the Peoria Lab in the U.S. to begin their work. “Pumping air into deep vats containing corn steep liquor and the addition of other key ingredients was shown to produce faster growth and larger amounts of penicillin than the previous surface-growth method” (Bellis). Florey found an easier way to process penicillin rapidly and in larger amounts, saving time and money. After his discovery, the drug was mass-produced and used on the war front, saving many lives (Connors). Without Florey’s achievement, penicillin would never have become the antibiotic used
Florey and Chain developed a system of growing penicillin: which was complicated initially, and tested its effectiveness on mice. The tests were successful and the two men became convinced that the drug would cure many people who would otherwise die. Florey and Chain were unable to expand on the development of the drug, as mass production was not financially feasible at the time. In June 1941, Florey travelled to America to try and interest drug companies there in developing penicillin. Due to the bombing of Pearl Harbour, the United States became involved in the Second World War.
Adegoke AA, Tom M, Okoh AI, Jacob S (2010) Studies on multiple antibiotic resistant bacterial isolated from surgical site infection. Scient Res. Essays 5:3876-81.
Penicillin, derived from the mold Penicillium, is the first antibiotic to successfully treat bacterial infections on humans. It was accidentally discovered by scientist, Alexander Fleming. While Fleming was growing Staphylococcus, a serious and often deadly infection, in a dish, he noticed the bacteria had stopped growing after a mold found its way
Years later other scientists were also intrigued by the possibilities of penicillin and produced enough penicillin to prove that it was a useable antibiotic. The scientists from Great Britain were developing all of this during World War II, and unfortunately funding for their drug was unavailable due to the war. They decided to bring their concepts to the United States, and once enough was made, it was eventually used, to treat wounded soldiers during World War I.
My disease is Streptococcal pneumonia or pneumonia is caused by the pathogen Streptococcus pneumoniae. Streptococcus pneumoniae is present in human’s normal flora, which normally doesn’t cause any problems or diseases. Sometimes though when the numbers get too low it can cause diseases or upper respiratory tract problems or infections (Todar, 2008-2012). Pneumonia caused by this pathogen has four stages. The first one is where the lungs fill with fluid. The second stage causes neutrophils and red blood cells to come to the area which are attracted by the pathogen. The third stage has the neutrophils stuffed into the alveoli in the lungs causing little bacteria to be left over. The fourth stage of this disease the remaining residue in the lungs are take out by the macrophages. Aside from these steps pneumonia follows, if the disease should persist further, it can get into the blood causing a systemic reaction resulting in the whole body being affected (Ballough). Some signs and symptoms of this disease are, “fever, malaise, cough, pleuritic chest pain, purulent or blood-tinged sputum” (Henry, 2013). Streptococcal pneumonia is spread through person-to-person contact through aerosol droplets affecting the respiratory tract causing it to get into the human body (Henry, 2013).
Penicillin became the first manufactured antibiotic after physician Alexander Fleming published articles regarding this bacteria-disabling mold in 1928. Come 1932, penicillin was commonly used to treat infected war injuries, saving the lives of unnumbered soldiers (Lewis). Since then, penicillin has become a popular treatment for numerous infections ranging from respiratory illness to syphilis. As society realized the benefits of penicillin, physicians began producing antibiotics to fight an infinite number of illnesses.... ... middle of paper ...
What does penicillin treat? There are several different kinds of penicillins, and they treat infections caused by bacteria. Each is used to treat different kinds of infections, and one kind of penicillin usually cannot be used to replace another. In addition, bacterial infections in many different parts of the body are treated with penicillins that work by killing the bacteria or preventing their growth. They are sometimes given with other antibacterial medicines.
18). Even though those diseases were not his goal to cure it still made penicillin revolutionary for the time being. Fleming now knew how to make penicillin and started to mass produce it. In the 1930s during the upgrading process of penicillin Fleming himself was cured of severe conjunctivitis. Then in the 1940s the fully developed penicillin was created. The creation of penicillin cured a wide variety of diseases, which led to the world excelling in growth, and penicillin improved the way of medicine at the time. The variety of diseases cured by penicillin made it a must have antibiotic. Penicillin was used to cure multiple diseases including syphilis, gonorrhea, tuberculosis, gangrene, pneumonia, diphtheria, and scarlet fever ( Common Antibiotics ). All the diseases have one thing in common, they all have the ability to spread, some faster than others. When a disease is discovered people tried to make a cure. When penicillin was made diseases that were thought to never have a cure were cured. People began to demand that penicillin be sold in local pharmacies. Penicillin was released to help people with the variety of diseases curable by
In 1928, Alexander Fleming, a Scottish biologist, pharmacologist, and botanist, discovered the first natural antibiotic: Penicillin. All of you reading this have at some point in time made use of his discovery. Penicillin antibiotics were among the first drugs to be effective against many previously serious diseases, such as syphilis and infections caused by staphylococci and streptococci. Antibiotics in general remain one of the cornerstones of modern health care, acting as something we all hope to rely on when we get sick. We could very easily name the 20th century “the age of the antibiotic,” and it would be well deserved, indeed. But time is running out.
Ernest Chain and Howard Florey with the knowledge of Flemings work were able to successfully purify an extract of penicillin for testing. The tested it in 1940 on mice, they concluded that those who were given the penicillin lived whereas the others did not. Later in 1945 all three men received the Nobel Prize for their contr...
Alexander Fleming started the history of antibiotics in the 1920's with his discovery of penicillin.When penicillin was first discovered and used widely, it was touted as a wonder drug, and consequently was used as one.Though not necessarily harmful to the patient penicillin was used for much more infections than it was able to combat.Today the same practice is observed in the medical profession, however at this point it is due more to the detriment of an uneducated public.Studies have been carried out that show the huge over usage of antibiotics.In the seventies Soyka et al, concluded, "60% of physicians surveyed gave antibiotics for the treatment of the common cold."[3], and by common knowledge the common cold is a virus, something that cannot be treated by an antibiotic.Nyquist
His second major discovery, and most probably his most famous, was on September of 1928. After a month away with family, Fleming returned to his lab, where he found that his culture of Staphylococcus aureus had been contaminated with a mold. The colonies of Staphylococcus aureus surrounding the mold, however, had been eliminated. Fleming decided to put the “mold juice” (now called penicillin) through a series of antibacterial tests. While at first Fleming thought penicillin to be a strong lysosome, he later found it to be an antibacterial property.
Discovery and Development of Penicillin. (2014, April 4). Retrieved from American Chemical Society International Historic Chemical Landmarks: https://www.acs.org/content/acs/en/education/whatischemistry/landmarks/flemingpenicillin.html
Incarceration is the act of imprisoning a convicted felon. The negative effects of incarceration seem to overshadow how beneficial it can to those with misdemeanors. The power of the church draws the more religious inmates in and gives them a new insight to life and to their religion. Many of the incarcerated did not plan that they would be in jail or prison; many had reasons whether it was childhood or drugs and alcohol, there are now groups that the inmates may attend in order to gain support, positive feedback, and help from others in similar situations. Education programs are also available to any who wish to continue (young adults) or go back to school in order to acquire a GED. From finding faith in a religion, to having a group support system, to getting your GED incarceration can have positive effects on prisoners, despite the negative publicity of prisons.
The discovery of antibiotics is attributed to Alexander Fleming who discovered the first antibiotic to be commercially used (Penicillin) in approximately 1928. An antibiotic, also known as an antimicrobial, is a medication that is taken in order to either destroy or slow the growth rate of bacteria. Antibiotics are integral to the success of many medical practises, such as; surgical procedures, organ transplants, the treatment of cancer and the treatment of the critically ill. (Ramanan Laxminarayan, 2013)