Organic Chemistry and Its Origins

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Brief History Jöns Jacob Berzelius, a physician by trade, first coined the term "organic chemistry" in 1807 for the study of compounds derived from biological sources. Up through the early 19th century, naturalists and scientists observed critical differences between compounds that were derived from living things and those that were not. Chemists of the period noted that there seemed to be an essential yet inexplicable difference between the properties of the two different types of compounds. The vital force theory (sometimes called "vitalism") was therefore proposed (and widely accepted) as a way to explain these differences. Vitalism proposed that there was a something called a "vital force" which existed within organic material but did not exist in any inorganic materials. {text:bookmark-start} {text:bookmark-end} Friedrich Wöhler is widely regarded as a pioneer in organic chemistry as a result of his synthesizing of the biological compound urea (a component of urine in many animals) utilizing what is now called "the Wöhler synthesis." Wöhler mixed silver or lead cyanate with ammonium nitrate; this was supposed to yield ammonium cyanate as a result of an exchange reaction, according to Berzelius's dualism theory. Wöhler, however, discovered that the end product of this reaction is not ammonium cyanate (NH4OCN), an inorganic salt, but urea ((NH2)2CO), a biological compound. (Furthermore, heating ammonium cyanate turns it into urea.) Faced with this result, Berzelius had to concede that (NH2)2CO and NH4OCN were isomers. Until this discovery in the year 1828, it was widely believed by chemists that organic substances could only be formed under the influence of the "vital force" in the bodies of animals and plants. Wöhler's synthesis dramatically proved that view to be false. Organic chemistry focuses on carbon and following movement of the electrons in carbon chains and rings, and also how electrons are shared with other carbon atoms and heteroatoms. Organic chemistry is primarily concerned with the properties of covalent bonds and non-metallic elements, though ions and metals do play critical roles in some reactions. The applications of organic chemistry are myriad, and include all sorts of plastics, dyes, flavorings, scents, detergents, explosives, fuels and many, many other products. Read the ingredient list for almost any kind of food that you eat — or even your shampoo bottle — and you will see the handiwork of organic chemists listed there. {text:bookmark-start} {text:bookmark-end} Major Advances in the Field of Organic Chemistry Of course no description of a text should be without at least a mention of Antoine Laurent Lavoisier.

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