Olivopontocerebellar Atrophy Olivopontocerebellar atrophy (OPCA) was first described in 1900 by Dejerine and Thomas. OPCA is a group of dominant inheritance and sporadic neurological disorders characterized by a chronic, progressive, cerebellar ataxia that begins in middle age. The cerebellum and its connections are the primary sites of the disease in chronic progressive disorders that often occur in familial or hereditary patterns. Postmortem studies indicate an atrophy of the cerebellum, pons, and inferior olives. This neuropathological neuronal cell loss permits classification of OPCA as a non-Alzheimer’s neurodegenerative illness. Gross postmortem inspection of the brains of patients with OPCA shows marked shrinkage of the ventral half of the pons, and disappearance of the olivary eminence on the ventral surface of the medulla. These brains also exhibit an atrophy of the cerebellum with degeneration of the middle cerebellar peduncles, and to a lesser extent, of the inferior peduncles. Thus, the cerebellum suffers mainly through atrophy of its afferent fibers. The neocerebellum and the olive undergo the primary degeneration. The purkinje cells of the cerebellar cortex are affected secondarily. Histological examination shows severe degeneration of Purkinje cells, reduction in the number of cells in the molecular and granular layers of the cerebellar cortex, severe loss of the number of cells in the pontine nuclei and olives, and demyelination of the middle cerebellar peduncle. The cerebellar nuclei are well preserved. The tegmentum of the pons, the corticospinal tracts, and the restiform body are also usually unaffected. In clinical cases involving extrapyramidal symptoms, degenerative changes in the striatum, espec... ... middle of paper ... ...s Elevated in Brain of Patients with Dominantly Inherited Olivopontocerebellar Atrophy. Neuroscience Letters (submitted publication). Kish, Stephen J. et al : Brain Amino Acid Abnormalities in Dominantly Inherited Olivopontocerebellar Atrophy. Revised manuscript in preparation for resubmission to J. Neurochemistry. Kish, Stephen J. et. al. Cognitive Deficits in Olivopontocerebellar Atrophy: Implications for the Cholinergic Hypothesis of Alzheimer’s Dementia. Annals of Neurology: 24 (2), 200-206, 1988. Rowland, Lewis P. (ed.): Merritt's Textbook of Neurology, eighth edition. Lea and Febiger. Philadelphia, 1959, pp. 630--631. Snell, Richard S: Clinical Neuroanatomy for Medical Students. Little, Brown, and Company, Boston, 1957, pp. 220--222. Walton, Sir John. Brain's Diseases of the Nervous System. Oxford University Press. New York, 1955, pp. 365.
Currently Dr. Correia is a Neuropsychologist at the Providence Veterans Affairs Medical Center. At Brown University, he is the Neuropsychology Intern Track Coordinator, the Director of the Neuropsychology Grant Writing Seminar and works in the MRI research Facility. He is the Assistant Director at the Neuroimaging Center at Butler Hospital and is also in the Imaging Core Executive Committee there.
Percy, A. K. (1999). Inherited neurodegenerative disease: The evolution of our thinking. Journal of Child Neurology, 14(4), 256-62. Retrieved from
The aim of this essay is a reflective account in which I will describe a newly acquired skill that I have learned and been able to implement within my role as a trainee assistant practitioner. (T.A.P.) for Foundation for Practice. I have chosen to reflect upon neurological observations on patients that will be at risk of neurological deterioration. Before I begin any care or assessments, I should have a good theoretical underpinned knowledge, of the skill that I am about to put into practice, and have a good understanding of anatomy and physiology, in order to make an accurate assessment of a patients neurological status. I will be making a correct and relevant assessment to identify any needs or concerns to establish the patient’s individualized care, and make observations to determine an appropriate clinical judgement.
Neurodegeneration is used mainly for diseases that are characterised by progressive loss of structure and function of neurons. There are many neurodegenerative diseases including amyotrophic lateral sclerosis that...
Chamberlin, Stacey L., and Brigham Narins. The Gale Encyclopedia of Neurological Disorders. Detroit: Thomson Gale, 2005. Print.
3)Parobek, Virginia M."Distinguishing conversion disorder from neurologic impairment".Journal of Neuroscience Nursing. 04/97. Volume 29. Number 2. p. 128.
... artists of Impressionism were Renoir, Morisot, Sisley, Monet, Pissarro and Seurat. Seurat once said that the colors of the Impressionist artists were “mixed by viewer’s eyes rather than artist’s palette” (Usborne 90), meaning that all the colors in the painting were mixed together in the viewers eyes to create what they saw. Also consisting of sudden poses and unusual points of view, the Impressionist period was one of the most famous periods of the arts.
In 1906, Dr. Alois Alzheimer discovered a “peculiar disease”. Dr. Alzheimer was an expert in linking symptoms to microscopic brain changes. Dr. Alzheimer noticed changes in the brain tissue of Auguste D., a patient who had died of an unusual mental disease. Her symptoms ranged from memory loss to unpredictable behavior. Afte...
R. L. Paul, M. M. (1972). The Species of the Brain Research, 1-19. pp. 113-117. S. A. Clark, T. A.
Impressionism grew out of and followed immediately after the Barbizon school. A distinctive feature of the work of the Impressionists was the application of paint in touches of mostly pure colour rather than blended; their pictures appeared more luminous and colourful even than the work of Delacroix, from whom they had learned the technique. To the modern eye, the accepted paintings of the salon artists of the day seem pale and dull.
The worldwide population is approaching 7 billion and is expected to reach 9 billion by 2050 (Baird). This projected population number is down from a once predicted 16 billion (Baird) and while some are not concerned, others are worried about any increase in population. Population growth is discussed in the articles “Too Many People?” by Vanessa Baird; “Population Control: How Can There Possibly Be Too Many of Us?” by Frank Furedi; and “The Population Bomb Revisited,” by Paul R. Ehrlich and Anne H. Ehrlich. Baird and Furedi concur that a concern for population growth has been around since mathematician Thomas Malthus, in 1798, warned that overpopulation could lead to “the collapse of society” (Furedi). Furedi claims that too much human life is being used as an excuse, by population control supporters, for the world’s current and future problems. Baird tries to discover if “the current panic over population growth is reasonable.” For Ehrlich and Ehrlich the concern over population growth is very real, and they reinforce and support their book “calling attention to the demographic element in the human predicament” (Ehrlich and Ehrlich 63). While taking different approaches to their articles, the authors offer their perspectives on population growth, population control and the environmental impacts of a growing population.
Sullivan, S. J., Hammond-Tooke, G. D., Schneiders, A. G., Gray, A. R., & McCrory, P. (2012). The diagnostic accuracy of selected neurological tests. Journal of Clinical Neuroscience, 19. 423-427. doi:10.1016/j.jocn.2011.09.011
One public figure that uses defense mechanisms to deal with issues is President Barack Obama. Denial is a defense mechanism that is used by the President. An example of this is the current immigration problem in the United States. Immigration was an issue when the President took office and it is still an issue now. He doesn’t acknowledge the problem. He refuses to accept reality that it is an issue. Another situation is Whitney’s denial of having a drug problem. Whitney did drugs for years but denied being addicted to drugs. Despite the fact that Whitney had heart disease and a hole in her septum she continued to abuse drugs and alcohol. Repression can be seen in Chris Brown, who observed domestic violence and was abused by his stepfather. According to Miller (2009), in 2007 Chris Brown revealed he had a history with abuse (Miller, 2009). Displacement can be seen at basketball games with LaBron getting angry at a call made by the referee and instead of saying something to the referee he would take his frustration out on the chairs and lash out at his fellow team mates. Another example of displacement is Kanya West disrespecting Taylor Swift at the MTV Awards. Kanya took his frustration out on Taylor, even though he was angry with MTV. Taylor Swift was just the target that West used to vent his frustrations. Sublimation can be seen in Kobe Bryant, Bryant claims he
The word “challenging behavior” can evoke feelings of frustration, anger, hostility or sense of helplessness in any parent, teacher or caregiver of a young child with behavioral challenges. Education.com (2006 - 2012) defines this term: as behavior that may impede with a child’s ability to learn, develop or play in a manner that is socially acceptable. They further define challenging behavior as behavior that could be potentially harmful to the child or others. This type of behavior in a young child, predisposes that child to social problems and academic failure (Klass, Guskin, and Thomas, 1995; Ritchie and Pohl, 1995). Marion (2011) defines challenging behavior as a stimulus that a child reacts poorly to, that in turn challenges the child’s parents or teachers to guide them in a positive manner. Current research indicates that children who have significant challenging behavior will have problems in school. They have issues with social skills, emotional control and language development. These insufficiencies contribute to the lack of skills to succeed in basic academic tasks such as reading (Coi, 1996). Traits that are often attributed to children who exhibit these traits are hyperactivity, inattentiveness and disruptive. Teachers are twice as likely to overlook them, ask them fewer questions and be low in positive responsiveness (Webster-Stratton & Herbert, 1994; Shonkoff and Phillips, 2000). Children with behavioral challenges face far greater difficulties with social and emotional development. Other children will tease and ridicule them, or reject them entirely. These experiences bruise a child’s self-esteem and confidence, they are left feeling depressed and isolated. Once a child accepts rejection, they fight or ...
An overarching issue that concerns all people due to its far-reaching implications is the subject of overpopulation. In the last two centuries, the global population has dramatically increased from 0.9 billion in 1800 to 7.6 billion in 2017. Some people may say growing population is beneficial since more people generates a bigger market and a bigger economy. On the other hand, the ramifications from dramatically increased population demonstrates the irrefutable negative facts on overpopulation. To understand the effects of overpopulation, it is imperative to explore its negative impacts on the environment, people’s lives, and the economy.