Myocardial Infarction: Pathophysiology

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Pathophysiology A myocardial infarction occurs when the coronary arteries become blocked. This blockage leads to decreased oxygenated blood flow to the heart muscle. The blockage is typically caused by a buildup of atherosclerotic plaque on the inside lining of the coronary arteries (What). If this plaque ruptures then a myocardial infarction will take place. When the plaque ruptures the immune system begins to respond by sending platelets to fight it. The problem here is that the platelets are sticky and they clot together. When platelets reach the site of the rupture they attach to it and make a blood clot. This decreases the open diameter of the coronary artery and causes less blood to reach the heart muscle. The heart muscle following

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