Myasthenia Gravis Research Paper

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Myasthenia Gravis:
Reducing Speech Weakness in Early Treatment

Myasthenia Gravis (MG) is an autoimmune disorder affected the neuromuscular junction and the process of neuromuscular transmission. MG is a disease that reflects an autoimmune response against acetylcholine (ACh) receptors at the postsynaptic membrane at the motor endplate (Duffy, 99). Because there are a reduced number of operative receptors, the muscle responsiveness to the Ach that sparks muscle contraction is reduced. The repercussion for this is diminishing muscle contractions with repetition of use. With rest and time for nerves to reload the Ach supply, strength of the muscles may improve.
Neurology of Myasthenia Gravis
Normal Neuromuscular Transmission In the process …show more content…

The AChR antibody works to block acetylcholine transmission. These antibodies reduce the number of ACh receptors as well as the amplitude of the End Plate Potential (EPP). The reduced EPP results from the loss of ACh receptors at the postsynaptic membrane (Newsom-Davis & Vincent, 5). The threshold for activation of the muscle action potential cannot be reached and the reduction in amplitude of the EPP leads to weakness from exertion (Thanvi & Lo, …show more content…

Immunosuppressant drug therapy works to suppress the body’s immune system. Immunosuppressant drugs are commonly called steroids, and those used in treatment for Myasthenia Gravis are more specifically known as corticosteroids. Our immune system produces antibodies to fight unwanted bacteria and viruses. Immunosuppressant drugs work to stabilize the overactive immune system, specifically, the ACh receptor antibodies.
Prednisone
Prednisone is a synthetic hormone that is similar to the natural hormone cortisone manufactured by your own body. In Myasthenia Gravis, the ACh receptor antibodies become overactive and attack the body’s tissues. Prednisone works to suppress the production of antibodies and stabilize the overactive immune system. Prednisone works against inflammation to reduce heat, redness, swelling, and pain. In the beginning of Prednisone immunosuppressant therapy, there is a possibility that it may cause seriously increased weakness for a short period of time. It is recommended that if you experience this weakness, one should be hospitalized (Myasthenia Gravis Foundation of America Inc.,

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