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Flashcards on adrenoleukodystrophy
Flashcards on adrenoleukodystrophy
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Recently in class we have watched the movie Lorenzo’s Oil. The movie’s plot revolves around a young man named Lorenzo Micheal Murphy Odone who at the age of five was diagnosed with a terminal illness known as ALD or Adrenoleukodystrophy. The adrenoleukodystrophy protein (ALDP) helps your body break down very long chain fatty acids (VLCFAs). If the protein doesn’t do its job, the fatty acids build up inside your body. This can harm the outer layer of cells, known as myelin, in your: spinal cord, brain, adrenal glands, and testes. People with ALD have mutations in the gene that makes ALDP. Their bodies don’t make enough ALDP. Victims were only expected to live two years after being diagnosed while exeprincing very severe symptoms. Including muscle …show more content…
Finally, entering a vegetative state in their last months. However, before Lorenzo contracted this very severe disease he was a very vibrant and intelligent boy. He speaks three languages, had many friends, and lived in south Africa for 6 months. In contrast during his time after diagnosis Lorenzo entered a nearly vegetative state, but he continued to fight until his Father, Augusto Daniel Odone, discovered the cure for his son’s ailment. Augusto Odone is Lorenzo’s father and a member of the world bank although he did give up on Lorenzo for a while he persevered and beat the odds were stacked against them by time, money, and a lack of research, so that he and his wife, Michaela Teresa Murphy Odone, could cure their son. The final major character of Lorenzo’s oil is Michaela Odone. She pushed the hardest for the cure to ALD. In the movie, she shows much compassion to Lorenzo by refusing to treat like a “vegetable” and still acting as if were capable to move as normal. These are the main characters of the movie. The movie has multiple settings, but all of them are either hospitals, research facilities or the Odone home
...hromosome and the disease/disorder is passed down in an X linked recessive fashion. Symptoms include muscle weakening and wasting, and pain in the lower body. Mostly only the lower body’s muscles are affected causing the child to have to be confined to a wheelchair. The best way to diagnose Duchenne Muscular Dystrophy is by doing a muscle biopsy to test for abnormal dystrophin levels. There is no treatment for the disease/disorder itself, but only for the symptoms of it. The average age of death in males with Duchenne Muscular Dystrophy is the late thirty’s. Most deaths are caused by breathing complications or heart problems like cardiomyopathy. Duchenne Muscular Dystrophy on average affects one in thirty five hundred male births worldwide. Overall, Duchenne Muscular Dystrophy is very hard to live with and affects many boys around the world.
...e progression. In DMD the muscle fibres are continuously damaged when the muscles contract. This causes inflammation which further damages the muscles leading to muscle wasting and the accumulation of scar tissue (‘fibrosis’). Drugs are being researched that could improve the ability of the body to repair damaged muscle, suppress inflammation and inhibit scar tissue formation.
Duchenne's muscular dystrophy, also known as psuedohypertrophic muscular dystrophy, is a typical sex-linked disorder in which the muscles degenerate throughout a person's life. It literally means "faulty nutrition of the muscles." Muscular Dystrophy has no cures, and this particular type of muscular dystrophy affects only males. One in 3,500 baby boys are born with this disorder and survival is rare beyond the early 30s, death is usually caused by a respiratory disease. (ygyh.org)
1. Lorenzo’s parents used the scientific method to solve the situation of lorenzo dying by coming up will solution to his ALD problem and stayed up late every night for years straight just to find a cure for ald and to save their child and all the other kids that suffer from ald and save their lives and many other life that may yet come and suffer from ald
Upton Sinclair’s novel Oil is one of his more socialist attacks on corporate power, labor suppression, government corruption and corporate control of war, universities, and Hollywood. The novel was written during the Harding administration Teapot Dome Scandal set in World War I and 1920s era, in the early California oil fields.
Richard Manning Wrote the essay “The Oil We Eat – Following the Food Chain Back to Iraq” which was published in Harper’s Magazine February 2004 edition. In this essay, Manning discusses the evolution of agriculture and the consequences of it. Furthermore, Manning explores the relationship of fossil fuel, food calories and transfer of energy to illustrate earth’s prospective future. Through the use of charismatically presented factual arguments, visual powerful emotional narratives and the credibility of a few choice names, Manning creates an environment in his essay that allows flaws to escape otherwise unknown to majority reader.
The setting in a story is not just the place where it happens; rather, it often acts in a symbolic way to help the reader understand further the thoughts and feelings of the characters. In Lorrie Moore’s “People Like That Are The Only People Here” (“PLTATOPH”) the setting acts as a place that traps the characters–or makes them a part of a cycle– and is often symbolic of the characters thoughts and feelings as they go through their journeys within the hospital.
Secondly, It appears as though Carlos has a much more difficult life than Nicole and it is she who is mentally ill. I believe this goes back to the discussion of Nature vs. Nurture, because nature plays a part in her genetics (mother). Furthermore, Nurture is a root of the problem because of the way she is raised by her father and stepmother, and her excessive use of alcohol. Looking at Carlos, he lives a much different type of life that is very planned out and strict.
Muscular Dystrophy is a genetic disorder in which your muscles drastically weaken over time. Muscles are replaced with “connective tissue,” which is more of a fatty tissue than a muscular one. The connective tissue is the tissue that is commonly found in scars, and that same tissue is incapable of movement. Although Muscular Dystrophy affects muscles in general, other types affect certain groups of muscles, and happen at different periods throughout a lifetime. For example one of the most common types, Duchenne Muscular Dystrophy, targets muscles in the upper thigh and pelvis. The disease is displayed throughout early childhood, usually between ages four and seven. This genetic disorder occurs only in boys. People have difficulty sitting up or standing and lose their ability to walk in their early teens. Sadly most people die by the age of twenty. A second common type, Becker’s Muscular Dystrophy affects the same muscles as Duchenne, but first appears in teenage years. Most people with Becker’s only live into their forties (Fallon 1824-1825).
Muscular dystrophy is a complex disease that has been around for many years. Although it was discovered in the 1830s there is constant discoveries about the disorder. (“New knowledge about Muscular dystrophy,” 2014 May 5) There are several research studies being done around the world to help find a cure. Here’s to hoping that a cure will be found and no more lives will be taken by this debilitating disease (“Muscular Dystrophy: Hope through Research,” 16 April 2014)
...t one has it. Many scientists hypothesize that there is an inflammatory response in the brain when there is an extensive B-42 amassing. To slow or stop this, scientists theorize that the use of anti-inflammatory drugs, such as aspirin, could delay the swelling in the brain. Also, as scientists have known that taking a multi-vitamin tablet each day is good for you, there has been recent research demonstrating that the use of antioxidants may protect neurons, not just the immune system and keeping the body healthy by providing vitamins and minerals. These special supplements protect the neurons from the effects of the accruing B-Amyloid that would likely cause the plaque that causes AD.
Amyotrophic lateral sclerosis, or ALS, is a degenerative disease affecting the human nervous system. It is a deadly disease that cripples and kills its victims due to a breakdown in the body’s motor neurons. Motor neurons are nerve cells in the brainstem and spinal cord that control muscle contractions. In ALS, these neurons deteriorate to a point that all movement, including breathing, halts. Muscle weakness first develops in the muscles of body parts distant from the brain, such as the hands, and subsequently spreads through other muscle groups closer to the brain. Such early symptoms as this, however, can hardly be noticed.
finding new ways to drill for oil and also refine it more efficiently to ensure that
The movie Lorenzo’s Oil is based on a true story. Lorenzo was a happy, bright and active young boy living in East Africa as his father was stationed there to work. When his parents, Augusto and Michaela Odone, were relocated back to the United States Lorenzo began to show unusual signs of disruptive behavior and balance issues. After medical exams the boy was diagnosed at the age of 5 with having adrenoleukodystrophy also know as ALD. A rare disease with no known treatment or cure with a life expectancy of becoming fatal with in 2 years.
The world, in which we are living, is being built and developed using much oil ever since the year of 1950. Many of a time, the food we eat, the cars we drive, the electricity we use need oil in order to be delivered, to operate and to be produced. Oil can have negative effects on economy as well, because oil can lead to unpredictable situations such as the decreases of oil prices recently or the peak oil crisis in July 2008. Therefore, I strongly agree that we should not heavily rely on oil as the primary energy resource.