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Biochemical role of hemoglobin and myoglobin
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Hemoglobin functions as transporter of oxygen molecular. The hemoglobin picks up O2 from the pulmonary system and delevers it to the body cells. oxyhemoglobin is a hemoglobin louded with O2 and deoxyhemoglobin is not louded with O2 . Blood in arteries is brighter red than the blood in veins. Hemoglobin molecule has four units of globin in addition to four units of heme. Estimation of serum Hb is a test that measures the level of free Hb in the liquid part of the blood (the serum). This test is done to diagnose or monitor the severity of a low RBC count caused by the abnormal breakdown of RBCs). Standard blood tests can also be performed on the blood that extracted from the arteries, like determining glucose level, hemoglobins and dys-haemoglobins, and electrolytes. The abnormal result indicate: -Drug-induced immune hemolytic anemia-G6PD deficiency-Hemoglobin C disease-Hereditary spherocytosis-Idiopathic autoimmune hemolytic anemia-Paroxysmal cold hemoglobinuria (PCH)-Paroxysmal nocturnal hemoglobinuria (PNH)-Sickle cell anemia-Thalassemia. An arterial blood gas (ABG) is a bloo...
Glucose is a sugar that plays a big part in a human’s health and well-being. This sugar is a major source of energy for the body’s brain and cells. The Cells that receive energy from glucose help in the building of the body’s muscle and tissue. Although glucose may be important to the body too much of this sugar can cause a chronic condition called Diabetes. Diabetes, also known as Diabetes mellitus, is a chronic condition that is caused by too much sugar in the blood. This condition can affect all age groups. In fact, in 2010 a survey was taken by the National Diabetes Information Clearinghouse, on the number of newly diagnosed diabetes. Out of 1,907,000 people: 24.38% were ages 20-44, 55.17% were ages 45-64, and 20.45% were ages 65 and greater. Diabetes is a very serious condition, and it can be deadly if left untreated. This paper will help better educate the reader on the signs and symptoms, the testing process, and the management of diabetes.
Homeostasis is the biological process that maintains a stable internal environment despite what occurs in the external environment. Chemicals and bodily functions are maintained in a balanced state so the body may function optimally. There are various systems in the human body that require maintenance through the processes of biochemical checks and balances so they may function properly. One of these systems includes the rise and fall of blood glucose and is under the control of the homeostatic regulation process. Homeostasis is essential in blood glucose regulation as high blood glucose levels (hyperglycaemia) and low blood glucose levels (hypoglycaemia) are dangerous and can affect the human body in many ways and can also lead
... to demonstrate that hemoglobin attaches to the VIVO2+ ion at two locations of comparable strengths, named β and γ. This study has also proven that the interaction of red blood cells cannot be ignored when the conveyance or the pharmacological properties of a V compound is taken into consideration. In general, this paper does well in supporting the information available concerning hemoglobin. This article boosts the information available, concerning the diseases, genetics and functions of hemoglobin proteins. The authors achieve this by getting down to the basic level via the examination of the crystallographic structures of hemoglobin. This research has demonstrated novel examples associated with hemoglobin, pertaining to its processes and its purpose of movement. This study has immense implications for the grasp and the management of various diseases of hemoglobin
The diminished rate of synthesis amongst the globin chains was first described from Cooley and Lee. However, the term “Thalassemia: was coined by Whipple and Bradford in 1936 (Bain, 2006). The term “Thalassemia” is derived from the Greek words “Thalassa” (sea) and “Heama” (blood) and refers to disorders associated with defective synthesis of the alpha or beta globin subunits of the hemoglobin molecule. Hemoglobin A (a2B2) is inherited. ...
Red blood cells with normal hemoglobin (HbA) move easily through the bloodstream, delivering oxygen to all of the cells of the body. Normal red blood cells are shaped like doughnuts with the centers partially scooped out and are soft and flexible.
Before WWI, the practice of medicine was far from how it has developed into today. The practice was not advanced, and therefore, had few concrete methods. However, with the beginning of the First World War, there was a great push to improve these methods. Although the war caused much illness and death, it also catalyzed many improvements such as blood transfusions, x-rays, vaccines, and sanitation.
Sickle cell anemia is a disease that reforms the patient’s red blood cells, which makes the red blood cells has an abnormal shape like a sickle. Sickled red blood cells can result to severe anemia; decrease causes numerous painful symptoms in patients. A defective protein called hemoglobin is what cause the abnormal shape of the red blood cells in the sickle cell patients.
Myoglobin consist of single polypeptide chain that made up of 153 amino acid and ahs a size of 18 kDa. Its three-dimensional structure was first determined by X-ray crystallography by John Kendrew in 1957. Myoglobin is a typical globular protein in that it is a highly folded compact structure with most of the hydrophobic amino acid residues buried in the interior and many of the polar residues on the surface. X-ray crystallography revealed that the single polypeptide chain of myoglobin consist of entirely of eight (labelled A-H) alpha-helical. Within a hydrophobic crevice formed by the folding polypeptide chain is the heme prosthetic group. This nonopolypepetide unit is noncovalently bound to myoglobin and is essential for the biological activity of the protein.
A patient with sickle cell has inherited the condition from both parents, and it all starts in the hemoglobin. Hemoglobin is “an iron-containing protein in red blood cells that reversibly binds to oxygen” (Reece, Urry, Cain, Wasserman, Minorsky, & Jackson, 2011). Obviously, hemoglobin is an important substance for oxygen to be transported in red blood cells. However, a patient with sickle cell has irregular hemoglobin cause by inherited genes. This “oxygen delivery” system cannot function properly because a gene
Blood typing works by detecting the presence and absence of A and/or B antigens on the surface of the red blood cells. An individual with type A has an A antigen, and a person with type B has a B antigen. People with type AB had both antigens and people with type O does not have the antigens. It is also used to determine Rh factor with anti- D antiserum. ABO blood typing is ascertained by adding a patient’s blood separately to an anti-A and anti-B antiserum and observe any signs of agglutination. Agglutination is happening to provide the reaction of the test. Agglutination with anti-A antiserum indicates the presence of A-antigen and type A blood. It goes for the same for the others, but different factors. Blood typing works because it determines a person’s blood type. It is important for the health care providers to know an individual's blood type on the grounds that a person has a blood transfusion or transplant. This is because not all blood types are compatible with each other. The blood type that is considered a “universal donor” is type O negative because there are no proteins (A and B antigens) on the red blood cells, which means anyone can receive the blood without suffering any rejections. The blood typing that is called the “universal recipient” is type AB blood because the immune system of a person with AB blood will accept blood from all possible donors, whether they have O, A, B, or AB
Red blood cells are carriers of oxygen. A percentage of these cells contain hemoglobin, which has the capacity to combine with iron. It's the iron-hemoglobin molecular structure that helps carry oxygen-rich blood from the lungs to your tissues and in return, delivers carbon dioxide back to the lungs to be expelled. A CBC with Differential that shows low red blood cell levels can indicate anemia. RBCs comprise about 40% of total blood volume; the RBC count is the number of red blood cells per cubic millimeter of blood (Rauen, 2012). Normal red blood cells values vary a...
Diabetes mellitus is a group of metabolic disorders which is characterized by hyperglycemia due to insulin deficiency or resistance or both reasons. (1) According to that diabetes mellitus can be divided as type I and type II. This is common and its incidence is rising, 171 million people had diabetes in 2000 it is expected this condition to be doubled in 2030. It is spread in all the countries and therefore has become a major burden upon healthcare facilities. (2)
Diabetes mellitus refers to a group of diseases that affect how your body uses blood glucose, commonly called blood sugar. Glucose is vital to your health because it's an important source of energy for the cells that make up your muscles and tissues. Glucose comes from two different sources, your liver and food. It's also your brain's main source of fuel. Glucose is made and stored in the liver. When your blood sugar gets low then your liver will use the stored glucose to keep your blood sugar level normal. If you have diabetes it means you have too much glucose in your blood. This is where insulin comes in. Diabetes is a growing epidemic in America's many nutritional diseases. There are a few factors that can cause or increase a person's chance of getting diabetes. Poor nutritional choices are a big factor in the cause of diabetes. The sad part is the increase is happening to the young children and teenagers in America. I will talk about what diabetes is, the increase in diabetes and why it’s so high, the complications that follow the diagnosis, and how it can be treated or reduced with diet and exercise.
Red Blood Cells contain hemoglobin molecules to help bind to oxygen to bring to other tissues. Without this function, cells would not be able to go through the process of cellular respiration and can only survive a short time. Red Blood Cells are also able to carry bicarbonate as a waste product and carry a variety of hormones to communicate between organs.
Blood transfusions have become a common part of medical care with nearly 5 million Americans a year receiving a transfusion. Blood transfusions are used in the treatment of many different conditions, from replacing blood lost in surgeries or injuries to fighting diseases like liver disease, anemia, and bleeding disorders like hemophilia (Nglbi.nih.gov, 2014). Blood collection and transfusion are overseen by many different agencies including the Department of Health and Human Services (HHS), the U.S. Food and Drug Administration (FDA) and the Centers for Disease Control and Prevention (CDC). Through these agencies work in donor screening and surveillance, blood transfusions usually cause no adverse reactions in the recipient and are considered a safe medical procedure. Despite this, blood safety remains an important public health matter both due to the seriousness of some adverse reactions when they do occur and the need for preparedness in reacting to future blood safety issues that can suddenly arise when new bloodborne diseases emerge. It is for these reasons that Healthy People 2020 has made reducing the proportion of averse reactions from the medical use of blood and blood products one of their objectives.