Heart Failure Essay

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It is essential to the human body that the heart pump sufficient nutrient rich blood to the body’s cells, because the body won’t be able to function normally otherwise. When a heart muscle is unable to pump enough blood through to meet the body’s regular demand it is characterized as heart failure. Heart failure can usually be treated through conventional heart therapies and symptom management strategies, however conventional therapies don’t work for all patients with heart failure, this is what is depicted as advanced heart failure or end-stage heart failure. In other words “End stage” heart failure is when the condition becomes so severe that all conventional treatments no longer work, the only treatment that works for end stage heart failure is to have a heart transplantation-surgery to remove a person's diseased heart and replace it with a healthy heart from a deceased donor. However there are two large encompassing problems with this treatment. The first problem is that the patient is subject to shortages in donor organ availability and thus possible further decompensation and potential death while awaiting transplantation. According to the American Heart Association, there are over 500,000 new cases of end-stage heart failure in the United States every year. With only 2200 donor hearts available every year nearly 20-30% of the patients who die while they await a transplant. The second problem with this mode of treatment is that not all patients qualify for heart transplantation. Patients who have another disease in addition to end-stage heart failure do not qualify for heart transplantation. The discrepancy between the clinical need for donor hearts and the total number of hearts available, as well as the lack of treatment o...

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...the best material for this application The future for the total artificial heart with respect to using polyurethanes comes in the form of thermoplastic polyurethane (TPU), also known as polyurethane elastomers that have molecular structures similar to that of human proteins. TPUs have slower protein absorption (protein absorption is the beginning of the blood clotting process) this makes TPUs ideal candidates in the manufacturing of the total artificial heart because it provides more adhesive strength and mimics certain elements within the body. Hence, biomedical polyurethanes can lead the way to eliminate some acute health challenges that the total artificial heart currently faces. By virtue of their range of properties, polyurethanes and their new applications will continue to play an important role in the future of the total artificial heart.

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