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The intense stimulant lysergic acid diethylamide (LSD) can briefly possess the mind of an individual who ingests it. As a result of its intensity and capability to open the "entryways of recognition," LSD could be violent to the psyche (Baker, 1999). It can seize the user's brain, tenderly uncovering life's dormant truths, or it can turn angry, decreasing the user to a state of complete panic. Obviously, LSD is not to be taken carelessly. This makes dosing an unknowing individual with it, particularly one who isn't familiar with LSD's properties, an especially frightful act. An individual unacquainted with LSD and completely unaware they had been dosed could be brought to the edge of mental breakdown.
In 1951, the Central Intelligence Agency (CIA) discovered that the Swiss drug manufacturer Sandoz Pharmaceuticals had 100 million dosages of LSD, accessible to any individual who wanted to purchase them. At the height of the Cold War, this was seen as a credible threat against the American public. The United States Army purchased the LSD, and shortly thereafter the military analysts and the CIA started Operation MKULTRA (Project MKULTRA, 1977). The experiments were primarily directed at consenting, willing respondents at colleges, CIA labs and independent research offices. However, some of these tests fell outside of the limits of adequate convention: One study tricked heroin addicts to take part as subjects by paying them in heroin, while another considered the impacts of LSD on African American detainees in a jail (Baker, 1999). The military organizations needed to know the degree to which it was conceivable to control human conduct through the utilization of psychoactive medications like LSD, mescaline, in addition to using psych...
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Project MKULTRA, the CIA's program of research into behavior modification. (1977). In U.S. Senate. Washington, DC: U.S. Government.
Freedman, B. (1987). Equipoise and the Ethics of Clinical Research. New England Journal of Medicine, 48, 44-48.
Miller, F. (2003). Therapeutic Misconception in the Ethics of Clinical Trials,. The Hastings Center Report.
Coleman, C. (2005). The ethics and regulation of research with human subjects. 3–50.50 Code of Federal Regulations, 46(102).
Faden, R. (1986). A history and theory of informed consent (pp. 114-159). New York, NY: Oxford University Press.
Hoever, K. (2005). The ethics of research using biobanks: reason to question the importance attributed to informed consent. Archives of Internal Medicine, 165-198.
Milgram, S. (1963). Behavioral Study of Obedience. Journal of Abnormal and Social Psychology, 67(4), 371-378
Sarah Cullen and Margaret Klein, “Respect for Patients, Physicians, and the Truth,” in L. Vaughn, Bioethics: 148-55
Those who were affected by the testing in hospitals, prisons, and mental health institutions were the patients/inmates as well as their families, Henrietta Lacks, the doctors performing the research and procedures, the actual institutions in which research was being held, and the human/health sciences field as a whole. Many ethical principles can be applied to these dilemmas: Reliance on Scientific Knowledge (1.01), Boundaries of Competence (1.02), Integrity (1.04), Professional and Scientific Relationships (1.05), Exploitative Relationships (1.07, a), Responsibility (2.02), Rights and Prerogatives of Clients (2.05), Maintaining Confidentiality (2.06), Maintaining Records (2.07), Disclosures (2.08), Treatment/Intervention Efficacy (2.09), Involving Clients in Planning and Consent (4.02), Promoting an Ethical Culture (7.01), Ethical Violations by Others and Risk of Harm (7.02), Avoiding False or Deceptive Statements (8.01), Conforming with Laws and Regulations (9.01), Characteristics of Responsible Research (9.02), Informed Consent (9.03), and Using Confidential Information for Didactic or Instructive Purposes (9.04), and Debriefing (9.05). These particular dilemmas were not really handled until much later when laws were passed that regulated the way human subjects could be used for research. Patients
LSD-25 or Lysergic Acid Diethylamide was first synthesized and used by pharmaceutical chemist Albert Hoffman. LSD-25 is an illegal drug belonging to the hallucinogen category. The physical effects are eye enlargement, pupil dilation and sweating. However the common psychological effects are euphoria, no recollection of time, visual distortions, and mentally visualizing geometric patterns and shapes, which lasts about 6-9 hours or sometimes longer. Though non-addictive LSD-25 can induce anxiety, paranoia, negative perceptions such as frightening visuals and sounds, feelings of insanity, and produce long-term effects such as flashbacks.
During the process of research, professionals collect data or identifiable private information through intervention or interaction. While this is a vital part of the scientific and medical fields, every precaution must be taken by researchers to protect the participants' rights. Ethics, outlined by the Belmont report; requirements, described by the Department of Health and Human Services (DHHS); and regulations, laid out by the Food and Drug Administration (FDA) are verified by an Institutional Review Board (IRB). This procedure assures that all human rights are safeguarded during the entire research process.
LSD has proved that the mind contains much higher powers and energies, beyond the average 10% of the brain that a typical human uses. These powers and energies, under the right circumstances, can be taken advantage of to benefit humankind spiritually, creatively, therapeutically, and intellectually. LSD has given humans the option to chemically trigger mental energies and powers. Arguments that LSD is potentially a dangerous discovery and mind control should be strictly prohibited by the government hold much validity, although there are benefits and arguments of personal freedom of neurology to consider. Whether LSD reflects negativity as a weapon and mind control drug, or radiates euphoria as a mind-expanding chemical and sacrament, the choice to engage in such an experience should be through personal reasoning.
Article two entitled “Clinical trials: are they ethical?” is written by Eugene Passamani discusses the importance of randomized clinical trials. Passamani rejects the argument that the physician-patient relationship demands that physicians recommend ...
At least one person committed suicide after becoming an unwitting subject of a CIA LSD test, crashing through a highstory plate-glass window in a New York hotel as his Agency guardian watched. (Or perhaps the guardian did more than watch. In June 1994 the victim’s family had his thirty-year-old corpse exhumed to check for signs that he may have been thrown out that window.) Numerous others lost their grip on reality.
Truog, Robert D., Walter Robinson, Adrienne Randolph, and Alan Morris. "Is Informed Consent Always Necessary For Randomized, Controlled Trials?" The New England Journal of Medicine 340, (March 1999): 804-807.
Steinbock, Bonnie, Alex J. London, and John D. Arras. "The Principles Approach." Ethical Issues in Modern Medicine. Contemporary Readings in Bioethics. 8th ed. New York: McGraw-Hill, 2013. 36-37. Print.
20 Feb. 2014. Nardo, Don. A. Biomedical Ethics.
Informed consent is a very serious decision a patient has to make when it comes to their health and consenting to procedures that are believed to cure or treat their current health status. It is important to address the effectiveness of the role a physician play in the informed consent process assuring that the patient has given truly informed consent and what safeguards can be put in place to assure the patient is exercising informed consent. Informed consent is based on the fact that the person consenting is a rational individual that is aware of the action to which he/she is consenting. Allen and McNamara (2011) notes that "On the standard understanding, the important elements of informed consent are the provision of information, the voluntariness of the choice and the competence of the chooser to make the choice— so the potential research participant should be provided with information relevant to the decision to participate, they should be able to choose freely about their participation and they should be competent to decide.
Freedman B. Equipoise and the ethics of clinical research. N Engl J Med. 1987; 317(3): 141-145
Nichols, D. E., & Chemel, B. R. (2011). LSD and the serotonin system's effects on human
McGee, Glenn and Arthur L. Caplan. "Medical Ethics." Microsoft® Encarta® 98 Encyclopedia. © 1993-1997: Microsoft Corporation. CD-ROM.
Milgram, S. (1963). Behavioural study of obedience. Journal of abnormal and social Psychology. 67 (4), p371-8.