Genetic Disorders: Heophilia A And Hemophilia B

Hemophilia is an inherited genetic disease that causes abnormal bleeding and the inability to make blood clots properly in the body. People with hemophilia are likely to bleed more following the events of an injury or surgery. There are two major types of hemophilia; Hemophilia A and Hemophilia B. Hemophilia A is the most common type of hemophilia. The disorder mostly affects males and causes increased bleeding. According to healthline.com, hemophilia A is caused by a deficiency in factor VIII and eight out of ten people who are diagnosed with hemophilia have hemophilia A. Hemophilia B is a genetic disorder that is caused by a low amount of blood protein; factor IX. Because of the lack of blood protein, blood cannot clot well to control bleeding. Hemophilia A and hemophilia B are similar but are caused by different substances in genes.

This is because the Queen of England, Queen Victoria was a carrier of the genetic disorder and her children passed the gene on to the royal families of Russia, Germany, and Spain, Hemophilia is located on the X chromosome, making males more likely to be diagnosed with the disorder. “Males inherited an X- chromosome from the mother and a Y- chromosome from their father. Females receive and X- chromosome from each parent. Because the genetic defect that causes hemophilia is located on the X- chromosome, fathers can’t pass the disease to their sons. This also means that if a male gets the X chromosome with the altered gene from his mother, he’ll have hemophilia. A female with one X chromosome that the altered gene has a 50 percent chance of passing hat gene to her children, male or female.”