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Describe autism spectrum disorder
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Gender Causes And Effects Of Autism Spectrum Disorder
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Recommended: Describe autism spectrum disorder
Autism is significantly caused in people by de novo mutation, deletions, duplications, genomic rearrangements, or point mutations in the germ line of one parent that causes loss of function or gain of function to a large number of genes. This can occur in any family with any genetic background and can appear in any offspring, regardless of gender. Offspring’s with mild disorders (asymptomatic carriers) i.e., females may marry and have children who inherit mutations in a dominant way. It is now obvious that the third-born male child is at high risk, i.e., his probability of being affected in comparison to the first two children being affected is nearly 50% with dominant transmission and high penetration. Females are at lower risk (20%) with lower incidence in females and reduced penetration in that gender. Explanation is yet to be given about disruptions on a single chromosome with incomplete penetrance that creates carrier states. [30] Females are resistant and therefore make logical carriers, but discordance between monozygotic twins suggest Autism Spectrum Disorder genotype and exi...
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928 Words | 2 PagesOne of the most characteristic features of Autism Spectrum Disorders (ASD) is its prominent higher prevalence among the male gender in comparison with the female gender. Although rates of ASD are consistent across cultures, these rates vary significantly by gender. It is the male gender that seems to be more affected by ASD with an average male-to-female ratio of 4.2:1, affecting 1 in 70 males and only 1 in 315 females (Fombonne, 2009). Although a well-known fact, the causes for such a great difference among sex ratios still remains unexplained, there are several hypotheses and studies trying to explain the reason for this inequality. In this paper I will outline some of the different attempts to explain the differences between the sex ratios. Among these attempts we can find diverse hypotheses that vary from the role of the sex hormones and genetic vulnerability to the biases of medical professionals during the diagnostic process (Goldman, 2013).
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Autism
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Autism Spectrum Disorder
1196 Words | 3 PagesAs the prevalence of Autism continues to grow rapidly, it is proven fact that Autism is the fastest-growing serious developmental disability in the United States. “On March 27, 2014, this surveillance study identified one in sixty-eight children (one in forty-two boys and one in one-hundred eighty-nine girls) as having Autism Spectrum Disorder (ASD).” (DSM-IV, 2000). Eight-hundred thousand people younger than eighteen years are on record as having Autism Spectrum Disorder in the United States. Most children display abnormalities within the first year of life; although most are diagnosed with Autism between the ages of two and three. Boys are nearly five times more likely than girls to have Autism. However, females with the disorder are more feasible to exhibit serious mental retardation. There are “approximately seventy-five percent of children with Autism are mentally handicapped; meaning their IQ ranges from thirty-five to fifty. According to the Diagnostic and Statistical Manual of Mental Disorders IV (DSM-IV, 2000) research suggests that only a small percentage of individuals with Autistic Disorder go on as adults to live and work independently.” ( DSM-IV, 2000)
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