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Genetics & future medicine
Genetics & future medicine
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Fulcrum Therapeutics • Overview & Details of the business: URL, location, number of employees, date founded. -Founded in 2016, Fulcrum Therapeutics is a privately owned biotechnological industry that specializes in Gene Regulation, Neuromuscular Diseases, Rare Genetic Diseases, and Cardiovascular Diseases treatment research. Fulcrum’s main focus is to define the molecular interactions of the small molecules with the target proteins. It is based in One Kendall Square Building 700 Cambridge, MA 02139 United States and employs 11-50 personnel. Some of its URL are; -www.fulcrumtx.com/ - https://www.linkedin.com/company/fulcrum-therapeutics -https://twitter.com/fulcrumtx • Details of services: what services do they …show more content…
Their motivation is to create a positive change in the patient and their families lives by developing small molecules that modulate the on and of control of mechanism that regulate genes. The two most common disease that their program is focused on are, Facioscapulohumeral muscular dystrophy (FSHD), and Fragile X syndrome (FXS). FSHD for example, is a progressive myopathic disease that affects humans of all ages caused by disrupted genetic and epigenetic regulation of a macrosatellite repeat (Himeda, Jones, & Jones, 2015). It is slowly progressive muscle disorder that affects 1 in every 20,000 individuals. Fulcrum is developing a small molecule that stabilizes the disease process through the restoration of the repressive DUX4 gene regulation as well as advising patient on the kind of step the should take to mitigate the complications from FSHD. At the moment, there are no known treatments that will reverse the weakening of muscle and wasting in FSHD (Fulcrum Therapeutics, 2017). For each of its two lead programs, Fulcrum is gratified to be working closely with patient groups who are partners in our search to better understand the disorders and to develop breakthrough medicines. For every program the company starts, we regard partnership with patient groups as essential to our …show more content…
The collaboration will incorporate the Horizon’s world-leading CRISPR-based screening technology to identify novel targets for regulating gene expression and subsequent manipulation (Horizon, 2016). • Financial: any financial details available? -Third Rock Ventures was the initial financier and founder of the Fulcrum Therapeutics with an out-front establishment amount of 55 million series A funding. In May 10th, 2017 Fulcrum announced that it had secured some additional series A funding from the (Google Venture) GV to facilitate the continued effort in the Fragile X syndrome (FXS). • Future plans: any indications of future plans for the business? -Fulcrum Therapeutics projects to be among the strongest biotech industries in term of technology, partnerships, venture backers and posting a competitive market position as their name as already appeared in the Fierce 15 biotechnology companies. “Fierce 15” are the top15 ranked biotechnology companies championing innovation and creativity by the biotech industry's daily monitor
Fibrodysplasia ossificans progressiva also known as FOP is a one of the rarest, most disabling genetic bone conditions known to medicine. FOP causes muscles, tendons, ligaments, and other connective tissues to turn in to bone. Movement becomes limited in the affected areas of the body. People with FOP typically have malformed toes at birth, meaning the big toe is typically shorter than normal and abnormally turned outward in a position called a valgus deviation. Symptoms of FOP start to show up in early childhood. Most people with FOP develop painful tumor-like swellings also known as fibrous nodules. The fibrous nodules are visible on the neck, shoulders, and back.
When people think of pharmaceutical companies, they instantly associate the word pharmaceutical with medicine. There are scientists solely dedicated to find the remedy to cancer and incurable diseases. These professionals have devoted their educated lives to help the ailing human population recover.
Nucleon is a small biotechnology start-up with a very promising potential product (CRP-1), which is also the first product that Nucleon is planning to go into the clinic market. Nucleon has reached to human clinical trials phase with its product and it has no manufacturing facilities that satisfy the guidelines for these clinical trials and testing. Nucleon is on the verge of making a critical choice of manufacturing strategy, which will affect Nucleon’s survival in the intense competition in the long haul. Nucleon management is aware of the facts that they have a limited budget to start with, the financial environment in biotechnology is rapidly changing and establishing the safety and efficacy of products like CRP-1 is complex, time-consuming and expensive; that’s why they want to evaluate risks and rewards of each manufacturing strategy before making their final decision.
Human beings are naturally defensive and react in certain ways to things such as them feeling that someone is judging them in a way that makes them feel uncomfortable. When it comes to drug users, approaching an addict telling them “You must stop taking drugs!” or “Drugs are going to kill you!” has not and will never work. It is more effective and sensible to approach them by informing them of the dangers of a specific drug to inform them of the potential harms that come along with the abuse of the drug. This is exactly where the policy of Harm Reduction falls into place. “According to the International Harm Reduction Association (2002) harm reduction is described as policies and programs which attempt primarily to reduce the adverse health, social and economic consequences of mood altering substances to individual drug users, their families and communities, without [necessarily] requiring decrease in drug use.(Perez)”
The use of alcohol and substances among adolescents has become a behavior that has been increasing all over the world. Over the years, substance use issues amongst adolescents have been treated with various forms of psychotherapy. More recently, research has shown that mindfulness based interventions aid adolescents with substance abuse problems in their recovery, maintaining sobriety, and to shy away from peer pressure (Burke, 2009). Mindfulness interventions may be beneficial for this population by aiding them to be non-judgmental, express openness, and accept their thoughts and feelings, hence impacting their thoughts, emotions, and behaviors (Robinson, Ladd, and Anderson, 2014). Adolescent substance use and misuse has become a public
When someone hears holistic nursing their mind may immediately jump to a form of hippie nursing with little to none scientific background or accuracy in the quality of care. This belief however is extremely inaccurate as to what holistic nursing really is. Holistic care can be defined as to when the nurse honors the patient’s wishes and takes into consideration the social, physical, emotional, and spiritual aspects of the patient’s life (American Holistic Nurses Association, n.d.). Holistic nursing is growing in popularity amongst patients because of its open communication between nurse and patient, its unique approach to health and healing, as well as the comprehensive care it can provide.
Many new players entered the market copying the same techniques for growth as Teva to capture a significant market share by offering low prices due to their low cost strategies. The entry of these players made the industry intense with tough competition, low profit margins and collapsed prices. The segment of drug industry where Teva had to come up with innovative drugs demands to invest high capital on R&D that was in billions for a single drug could potentially lower the growth and revenues for Teva and could push the company into serious trouble. Analysis To build some effective and real world alternatives and recommendations to Teva Pharmaceuticals, we will conduct the following analysis to understand the external and internal situation of the company. Internal and External Analysis SWOT Analysis (Exhibit 1) Strengths:
Today, many Americans face the struggle of the daily hustle and bustle, and at times can experience this pressure to rush even in their medical appointments. Conversely, the introduction of “patient-centered care” has been pushed immensely, to ensure that patients and families feel they get the medical attention they are seeking and paying for. Unlike years past, patient centered care places the focus on the patient, as opposed to the physician.1 The Institute of Medicine (IOM) separates patient centered care into eight dimensions, including respect, emotional support, coordination of care, involvement of the family, physical comfort, continuity and transition and access to care.2
“Integration is a method of utilising more than one theory in the belief that by combining or integrating these theories the chance of a successful outcome for the client is increased.”
We first began our analysis of Novartis by evaluating the company’s strategic direction. Novartis’ mission statement is to care and to cure. They are a company that wants to discover, develop, and successfully market innovative products to prevent and cure disease, to ease suffering, and to enhance the quality of life. Novartis also hopes to provide a shareholder return that reflects outstanding performance and to adequately reward those who invest their money, their time, and their ideas in their company. Like most companies in the industry, Novartis’ vision is to become the best pharmaceutical company through the achievement of sustainable and profitable growth. Novartis has a performance oriented culture and top down leadership style. By having a performance oriented culture the business pushes creativity and free thinking while focusing ...
There are many different techniques and approaches to group counseling. The approach that I found to be the most interesting is the existential approach. “The existential perspective holds that we define ourselves by our choices” (Corey & Corey, 2014, p.114). This approach can be successful in therapy because it allows one to oversee one’s future. In this paper, I’m going to generally discuss the existential approach to therapy and where it can be used.
Health psychology is a relatively new concept rapidly growing and could be defined as the biological and psychological influences affect ones behaviour also bringing in social influences of health and illness (MacDonald, 2013). Biological determinants consider genetic and biological factors of an illness whereas psychological determinants focus on the psychological factors such as why people behave the way they do when dealing with issues such as anxiety and stress. Models such as the Health Belief Model and Locus of Control were developed in attempt to try and explain psychological issues around a chronic illness such as breast cancer (Ogden, 2012). Sociological factors can cause an enormous amount of pressure for one to behave in a certain way for example gender roles in society and religious considerations when dealing with health beliefs. Health Beliefs can be defined as one’s own perception to their own personal health and illness and health behaviours (Ogden, 2012). There are also theories and models used to explain pain and coping with diagnosis such as Moos and Schaefer (1984) Crisis theory and Shontz (1975) cycle of grief people go through when being diagnosed with a serious illness.
Do you want to know more about how to achieve holistic health and development? This article will surely help you since it is mainly designed to give some tips and ways to readers on how they can have a healthy lifestyle and achieve holistic development.
Personal health is extremely important to everyone around the world. But it is especially important to citizens of the United States of America. Being one of the leading countries in Health technology and also in food and beverage leaves most people choosing between living a healthy lifestyle and indulging in the varieties of food we offer. Across the country, many people are living with pre-existing conditions, living in food deserts, living below the poverty line and a long list of other factors that either hinders them from eating healthy or force them to eat healthily. When trying to live a healthy lifestyle in this country not only does the promotion of prevention matter, but also the promotion of Career and job opportunities matter just as much. In the United States, Money equals Power and money also equal the opportunity to create and live a healthier lifestyle.
Health is considered a complete wellness of a body including physical, mental and social well-being and Holistic Health is considered a wellness of a whole body including mind, body and spirit. According to American Holistic Medicine Association “Holistic medicine is the art and science of healing that addresses the whole person – body, mind and spirit” (Wollumbin, page 3). Holistic Health is an alternate way to treat, prevent, and wellness of an illness and achieves the best possible level of health. It focuses on the whole body rather than just symptoms or diseases. It is an approach to heal the physical, psychological, environmental, spiritual, nutritional health of one’s being. For each individual, the definition of holistic health is different and in simple words it is an alternate way of treatment where physical, mental, emotional and spiritual works equally together to attain a health. In western medicine, standard treatment is given with drugs or surgery according to symptoms or diseases or injuries where a doctor or a physician determines the ways of treatment and the patient has to follow the recommendations. Whereas, holistic health is a complete opposite way to treat the illness where patients cooperate in their illnesses, take the responsibility of their treatments, make their own decision for own level of well-being and thoroughly participate in their health care plan.