Estrogen Receptor Positive (SER

2123 Words5 Pages

Introduction

Breast Cancer is on the forefront of modern tumor research and scientists are continually seeking new ways to treat and prevent cancer progression. Current treatments using hormone-dependent drugs like Tamoxifen and Raloxifene focus on estrogen receptor inhibition in mammary and endometrial cell lines. The estrogen receptor is heavily targeted in breast cancer treatment because it is easy to inhibit has strong affinity for binding to many molecules mimicking the estrogen hormone - inducing cell proliferation in the breast and endometrium. Estrogen receptor drugs are known as selective-estrogen receptor modulators or SERMS, which are effective in estrogen-receptor positive (ER+) and hormone-estrogen receptor 2 positive (HER2+) …show more content…

It is suspected that F-Ren is desensitized at older ages in women (Veronesi, 1999). During high periods of cell proliferation in the mammary and endometrium in women, i.e menstrual cycle and pregnancy, there is an increased chance of developing a mutation that will produce a cancer cell. When women reach menopause and stop producing as much hormones (like estrogen) that interact with those sites – it may deter F-Ren from inducing apoptosis. F-Ren might, therefore, be stunted or aided by hormones in breast carcinogenesis based on age (Veronesi, …show more content…

Combination therapy with a SERM and retinoid functions more efficiently than either alone in combatting IGF-1 induction of tumor proliferation and secondary tumor progression. Specific inductions by F-Ren on apoptotic activators and increased oxidative stress produced by F-Ren and Tamoxifen, which works against hormone-related cell proliferation, together create a synergistic and effective treatment for breast cancer patients. With successful in vivo and in vitro studies, graduating the complex to clinical trials with relatively low side effects, is a great sign in the future of a possibly new technique in treating a broad range of breast cancer

More about Estrogen Receptor Positive (SER

Open Document