Epilepsy Essay

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Epilepsy is a disorder of the brain characterized by an enduring predisposition to generate epileptic seizures,1 and by the neurobiological, cognitive, psychological and social consequences of this condition. An epileptic seizure is a brief disturbance of consciousness, behavior, emotion, motor function, or sensation that is due to abnormal electrical discharge in the brain.2 In partial-onset epilepsy, these bursts of electrical activity are initially focused in specific areas of the brain, but may become more generalized, with symptoms varying according to the affected areas. Epilepsy is the most common serious neurological condition in the UK.3 The World Health Organization (WHO) estimated its prevalence to be affecting approximately 5-8 per 1000 people.4 Anti-epileptic drugs (AEDs) are the major therapeutic option. Over a dozens of AEDs are introduced in the last 2 decades (Table 1.1). Between 1990 and 2011, 15 new antiepileptic drugs (AEDs) were approved by the US Food and Drug Administration (FDA) and/or by the European Medicines Agency (EMA). These drugs are Eslicarbazepine ace...

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