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Thesis on gene therapy
Thesis on gene therapy
Cystic fibrosis community research paper
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Cystic Fibrosis and Gene Therapy
The average life span of a person with Cystic Fibrosis is 25-30 years of age. Although the more traditional treatments of this disease are adequate, is there something else that could be even better? Gene therapy is fast becoming one of the more studied aspects of genetics today. Let's take a look at some details of Cystic Fibrosis and gene therapy.
Technical Aspects
Cystic Fibrosis (CF) is the most common fatal genetic disease in the United States today. CF is an autosomal recessive disease that occurs approximately one out of 3,300 live births (Cystic Fibrosis Foundation, 1998). Autosomal means that the gene for CF is not carried on the sex chromosomes and males and females are both afflicted by this disease. Recessive inheritance is when both parents "carry" the abnormal gene in their DNA but they themselves do not show evidence of the disease. The mother and father have one normal gene and one abnormal gene and don't show signs of disease because the normal gene dominates the abnormal gene. To have CF, a child must inherit two abnormal genes, one from each parent. Remember that chromosomes are made up of DNA or deoxyribonucleic acid. DNA is made up of genes, and genes are made up of building blocks called base pairs. The specific gene responsible for CF was identified in 1989 on human chromosome 7 (Pseudomonas Genome Project, 1998). A mutation, or change in the genetic material, resulting in a substitution or loss of one of the base pairs causes the CF gene to be abnormal (Cystic Fibrosis Foundation, 1995).
CF does not affect all people the same way. The basic problem for all patients however is an abnormality in glands, which produce mucus or sweat. The mucus produced by people...
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...ctsabo.htm">http://www.cff.org/factsabo.htm
Cystic Fibrosis Foundation, "Gene Therapy". Obtained from the WWW 10/31/98: http://www.cff.org/genether.htm
Genentech Incorporated, "Gene Therapy-An Overview". Obtained from the WWW 10/31/98: http://www.gene.com/AE/AB/IWT/Gene_Therapy_Overview.html
McClean, Phillip. "Variation in Chromosome Structure". Obtained from the WWW 10/15/98: http://www.ndsu.nodak.edu/instruct/mcclean/plsc431/chromstruct/chrmo2.htm
Pseudomonas Genome Project, "Cystic Fibrosis". Obtained from the WWW 10/31/98: http://www.pseudomonas.com/cystic_fibrosis.html
Cystic Fibrosis Foundation, "An Introduction to Cystic Fibrosis for Patients and Families" in Respiratory Diseases and Disorders Sourcebook". Health Reference Series, V. 6, 1995. Sect. 5.1, p. 240.
WWWebster Dictionary. Obtained from the WWW 11/2/98: http://www.m-w.com/
...many pros and cons that go along with the novel written by Steve Bogira. Some pros that go along with Bogira’s novel is that he does a good job capturing the history of the courthouse and how it’s been brought up from its early beginnings. Bogira also does a good job with following and going though Judge Locallo’s daily routine and problems that he faces as being a judge in one of America’s busiest felony courtrooms Though Bogira’s novel is a thorough detailed account of what happens in a year in one of America’s most hectic courtrooms, it can be seen as only a representation of the court system in Chicago since courtrooms across the country can differ from state government to state government. Bogira’s novel though, however, does give an accurate description of the problems that can still continue today, plaguing the court system within this country. Corruption is
Cystic Fibrosis (CF) Pathophysiology: Cystic fibrosis is a genetic disease of the secretory glands that affects the respiratory and digestive system. It mainly affects the lungs, pancreas, liver, intestines, sinuses, and reproductive organs. Cystic fibrosis affects the cells that produce sweat, mucus, and digestive fluids. Mucus becomes thick and sticky, causing build-up in the lungs and blocking airways, making it easier for bacteria to develop. This prompts repeated lung infections and can cause severe lung damage after some time.
CF is a chronic condition therefore the patients are either seeking medical attention or receiving (sometime involuntarily) a great deal of medical scrutiny and intervention during their lifetime.
Along with the problems of chronic illnesses themselves, many other problems may come. Treatments and medications are just the beginning of things when it comes to problems with illnesses. With cystic fibrosis, you start out with a high number of medications and treatments to begin with. The older you get and the worse your condition gets, the more you take. (“Psychological impact,” n.d.) Many struggles come along with taking these medications and treatments. When children are first diagnosed with cystic fibrosis, they are typically very young. From the beginning, there are many medications and treatments that needed to be taken and done. Sometimes, trying to get children to take medications and treatments is like pulling teeth. The medications for cystic fibrosis are extremely important. If cystic fibrosis patients miss medica...
Haas, D. F. (1990). The Chronic Bronchitis And EMPHYSEMA. New York,NY: John Wiley and Sons, Inc.
In the Shadow of Illness, the book describes different experiences of families who have or had children with cystic fibrosis (CF). CF is an inherited disease that is passed on from the mother or father who is a carrier, but doesn’t have the condition. Doctors have figured that in this scenario, the parents are likely to have a child with CF. Individuals with CF have to take Cotazymes to help the pancreas digest food. If the person does not take these enzymes, the food goes straight through them as diarrhea. Also, the person’s lungs are affected by a thick mucus that must be removed or thinned before it clogs. Doctors recommend the patient to perform daily breathing exercises that prevent the mucus from thickening; for example, swimming
Modern molecular genetics has given hopes and heartaches to thousands of people around the world. These people are looking towards gene therapy for an answer to their questions. To some people such as NIH director Harold Varmus the answer is a better understanding of basic genetic research and to others the answer is a cure, a hope, that their lethal disease will someday be cured. This essay touches on the background of gene therapy for Cystic Fibrosis (CF), current social and ethical issues facing gene therapy for CF, and some thoughts on the importance of this controversial subject.
In A Doll’s House, Ibsen portrays his lead character, Nora, who is a housewife in the Helmer’s family. She has undergone a transformation throughout the play that she reacts differently to her husband. Her husband, Torvald, is an example of men who are only interested in their appearance and the amount of control they have over a person. In particular, he has a very clear and narrow definition of a woman's role. At the beginning of the story, as from the title of the play, Nora symbolizes the “doll” in the house, which means that she has been treated as treats Nora like a child or doll. For example, husband called Nora ‘bird’ and it implies that husband treats her like his pet and she is his doll as the title is a doll house. In other words, her husband wanted her to be a ‘lark' or ‘songbird' so he can enjoy h...
Chronic obstructive pulmonary disease (COPD) is preventable disease that has a detrimental effects on both the airway and lung parenchyma (Nazir & Erbland, 2009). COPD categorises emphysema and chronic bronchitis, both of which are characterised by a reduced maximum expiratory flow and slow but forced emptying of the lungs (Jeffery 1998). The disease has the one of the highest number of fatalities in the developed world due to the ever increasing amount of tobacco smokers and is associated with significant morbidity and mortality (Marx, Hockberger & Walls, 2014). Signs and symptoms that indicate the presence of the disease include a productive cough, wheezing, dyspnoea and predisposing risk factors (Edelman et al., 1992). The diagnosis of COPD is predominantly based on the results of a lung function assessment (Larsson, 2007). Chronic bronchitis is differentiated from emphysema by it's presentation of a productive cough present for a minimum of three months in two consecutive years that cannot be attributed to other pulmonary or cardiac causes (Marx, Hockberger & Walls, 2014) (Viegi et al., 2007). Whereas emphysema is defined pathologically as as the irreversible destruction without obvious fibrosis of the lung alveoli (Marx, Hockberger & Walls, 2014) (Veigi et al., 2007).It is common for emphysema and chronic bronchitis to be diagnosed concurrently owing to the similarities between the diseases (Marx, Hockberger & Walls, 2014).
The clinical manifestation one may see in patients with chronic bronchitis are chronic cough, weight loss, excessive sputum, and dyspnea. Chronic cough is from the body trying to expel the excessive mucus build up to return breathing back to normal. Dyspnea is from the thickening of the bronchial walls causing constriction, thereby altering the breathing pattern. This causes the body to use other surrounding muscles to help with breathing which can be exhausting. These patients ca...
Parker, Steve. "Chronic Pulmonary Diseases." The Human Body Book. New ed. New York: DK Pub., 2007.
Antibiotic resistance is bacteria’s loss of susceptibility to the bactericidal or growth-inhibiting properties of an antibiotics. When a resistant strain of bacteria is the dominant strain in an infection, the infection may be untreatable and deadly he primary mechanisms of bacterial gene transfer are transduction and conjugation. Transduction occurs when a bacterial virus, called a bacteriophage, detaches from one bacterial cell, carrying with it some of that bacterium’s genome, and then infects another cell. When the bacteriophage inserts its genetic content into the genome of the next bacterium, the previous bacterium’s DNA also is incorporated into the genome. Conjugation occurs when two bacteria come into physical contact with each other and a plasmid, sometimes carry...
Inception was one of the films that make you question what is reality compared to a dream. Christopher Nolan does an amazing job on having the viewers really think about what is going on throughout the whole movie. Nolan uses different angle shots, crazy rotations, and a great story to have this amazing film hit theaters. This film was not only to have viewers question “what is reality,” but it also is a rollercoaster ride throughout the whole entire film.
Lawson, Fred H. "Syria." Politics & society in the contemporary Middle East. Boulder, Colo.: Lynne Rienner Publishers, 2010. 411 - 434. Print.
Hence, as a nation, we need to enhance our current law enforcement laws pertaining to our endangered species. As a major marine export in the Bahamas, conch bring millions of dollars to the Bahamian economy annually, therefore we should re-evaluate the total amount of conch that we export from The Bahamas. We cannot afford to lose our Bahamian delicacy. As the King of Rake ‘n’ Scrapesays, “We is a conchy nation, we need to pass conchservation, can’t afford to eat them all, especially when they too small. Yes we love our conch indeed, but we gat to let them breed. Cause we is a conch nation we need to pass conchservation.”(Bodie, 2013) Conservation: Let’s preserve our Bahamian Delicacy.