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Ceutzfeldt-jakob disease papers
Ceutzfeldt-jakob disease papers
Ceutzfeldt-jakob disease papers
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Plenty of people love the fact that they can enjoy life normal because their brain functions accordingly. Well not every one has the gift of normality. In this harsh world people are dying of all types of diseases and things that are undetectable or even treatable due to the fact that they have unknown origins. Many of the world’s diseases such as HIV, AIDS, some cases of Multiple Sclerosis and Muscular Dystrophies. Among these fatal and life threatening ailments Creutzfeldt-Jakob disease, other wise known as (CJD), takes precedence.
Creutzfeldt-Jakob disease (CJD) is an unusual, degenerative, consistently terminal brain disorder, typically onset of symptoms occurs at about age 60. This disease has been categorized into three major categories: 1) sporadic CJD, 2) hereditary CJD, 3) acquired CJD.
In sporadic CJD, the disease occurs even though the affected does not have any known risk factors that would cause an occurrence of the disease. This sudden occurring CJD is indisputably the most frequently diagnosed type of Creutzfeldt - Jakob disease. This statistically accounts for at least 85 percent of CJD cases. Due to that there are some fifty to sixty deaths per year due to sporadic CJD in the United States alone. Similar figures are seen in other countries such as Australia, Canada and the United Kingdom.
In hereditary CJD, the infected person has inherited an abnormal gene due a family history of the disease or takes a test in which their results are positive for a genetic mutation that is associated with Creutzfeldt-Jakob disease. About 5 to 10 percent of cases of Creutzfeldt - Jakob disease in the United States are hereditary and the United Kingdom has a population in the region of 58 million and there are only a few instances of deaths due to genetic CJD in a year.
In acquired CJD, the disease is transmitted by exposure to brain or nervous system tissue, usually through certain medical procedures. Acquired CJD is also very rare; so far there has been no solid evidence that CJD is transmittable through casual encounter with a patient with CJD. Since Creutzfeldt - Jakob disease was first discovered in 1920, less than 1 percent of cases have been diagnosed as acquired CJD.
Creutzfeldt - Jakob disease (CJD) belongs to a family of human and animal diseases known as the transmissible spongiform encephalopathies (TSEs). Spongiform refers to the distinctive look of contaminated brains, which become filled with holes until they bear a resemblance to sponges when seen under a microscope.
Tay-Sachs disease is a rare and fatal genetic disorder that destroys neurons in the brain and spinal cord. The disease appears in three forms, Juvenile Onset, Late Onset (known as LOTS), and the most common form, Infantile (also known as Classic). The differences between the three forms of the disease are related to the age at which the symptoms of the disease begin to form. Tay-Sachs results from a deficiency of the enzyme hexosaminidase A, which plays a vital role in removing a fatty substance, called GM2 gangliosides, from neurons.
Percy, A. K. (1999). Inherited neurodegenerative disease: The evolution of our thinking. Journal of Child Neurology, 14(4), 256-62. Retrieved from
It is hard to comprehend how and why people lose their sanity and become mad. I will address how the mind’s struggles caused by individual genes, stress and social-cultural influence affect the lives of Naomi, a 24-year-old college student with schizophrenia and Eric, a 27-year-old classical musician with severe depression. Their thoughts and behavior surprised me as this is my first time exposed to what these mental illnesses are. The relation between the mind and the body and the fact that the emotions affect the functioning of the body and vice versa explains the how and why a person become insane.
In the book it says "They can spend a whole lifetime worrying whether they 're carriers, and then we come along and offer them a test. Recessives and X-linked. Look what they 're doing with fragile-X nowadays. And cystic fibrosis. Just imagine the commercial possibilities if you can design and patent a probe for something like Gaucher 's disease...(69)" Recessive traits is the phenotype is seen only a homozygous recessive genotype for the traits of the interest is present. The booked talked about two of three diseases that are most common in the Ashkenazi Jewish population. The first one is Cystic fibrosis which is an inherited life-threatening disorder that effects the lungs and the digestive system. The other one mention in the book that wasn’t mention in class was Gaucher 's disease. Gaucher 's disease is a build up of fatty substances in your organs, usually in you spleen and liver. Which causes them to become bigger affecting their function. The last one that we learned in class was Tay-Sachs disease, which is a rare inherited disorder that destroys nerve cells in the brain and spinal
· genetics: occasionally the disease has a tendency to run in certain families (inherited or genetic predisposition), but this is not common.
As you can see there are a few common mispellings of Crohn 's Disease. The definition of Crohn 's Disease is a chronic inflammatory disease of the intestines, especially the colon and ileum (the 3rd portion of the small intestine, between the jejunum and the cecum), associated with ulcers and fistulae (an abnormal or surgically made passage between a hollow or tubular organ and the body surface, or between two hollow or tubular organs). In layman terms the definition of Crohn 's Disease is best explained as The body 's immune system tries to cure the digestive tract, but the digestive tract does not really need curing because it is not sick. The tissue of the digestive tract then becomes inflamed. The inflammation starts to eat away at the lining o...
The origin of CWD has yet to be determined (Sigurdson & Aguzzi, 2007). The infection was first noted in 1967 at a captive mule deer research facility. In 1978 pathologists recognized the TSE type brain lesions, also that CWD presented as a prion disease by the neuronal perikaryonic vacuoles, the accumulation of aggregated prion protein and prion infectivity in the brain. In the late 1970s and early 1980s the infection w...
Cystic fibrosis is one of the most common lethal mutations in humans. The autosomal recessive allele is carried by 1/20 Caucasians, 1/400 couples will have children with the disease, and ¼ children will be afflicted. If untreated, 95% of affected ch ildren will die before age five (Bell, 1996).
Autopsies of affected cattle reveal holes in the brain tissue that give it a spongy, or spongiform, texture. Similar spongiform diseases have been recognized in humans (for example, Creutzfeldt-Jakob disease or CJD) for over a century and in sheep (scrapie) for over 200 years. The cause of BSE is unproven, although there is strong evidence that prions, which may be infective proteins, are the agent. Other hypotheses suggest that prions work with an as yet undetected virus to cause the infection.
Chronic Wasting Disease is a highly transmissible, deadly neurodegenerative disease that affects cervids in North America (Belay et al., 2004; Saunders et al., 2012). There are only four types of cervid that are known to get this disease which include elk, mule deer, white-tailed deer, and moose (Chronic Wasting Disease Alliance). It has been classified has a transmissible spongiform encephalopathy (TSE), otherwise known as a prion disease (Belay et al., 2004). A prion is an irregular, pathogenic agent that causes abnormal folding of specific proteins called prion proteins. These proteins are mostly located in the brain (Chronic Wasting Disease Alliance). The abnormal folding of this protein causes neurodegenerative diseases in a variety of species including humans, sheep, cattle, and deer (Abrams et al., 2011).
Cri-du-chat is a rare genetic disorder discovered by Jerome Lejeune in 1963. It is caused by the deletion of genetic material on chromosome five, an autosomal chromosome. The deletion occur on the "p" arm of the chromosome. Scientists do not know the reason why this chromosome deletion occurs.
This disease is caused by a defective gene and was discovered in the 1930's. Scientists are
Prion Disease is an illness that many have not heard about. This is sad because many have died and are dying from this disease that doesn’t yet have a cure. “Prion Disease is a group of conditions that affect the nervous system in humans and animals… these conditions impair brain functions, causing changes in memory, personality, and behavior; a decline in intellectual function (dementia); and abnormal movements particularly difficulty with coordinating movements (ataxia)” (Genetics Home Reference). This is basically the definition of what Prion Disease is and without going into depth it explains how it affects the person that is affected. “In t...
Since the gene for HD is dominant, there is a 50% chance of a sufferer's
caused when the molecules in the synapses of an autistic person don’t function properly. Some of