Copper In Biochemistry

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Copper is an important element that has a significant role the function of enzymes. Copper acts as a cofactor in many essential enzyme reactions such as those involved in metabolism. Nevertheless, copper is a redox-active transition metal and is linked to generating reactive oxygen species (ROC). Especially under anaerobic conditions when copper is in its oxidative state. So copper can be highly toxic to cells and lead to cell death even in very low concentration. Its antimicrobial properties are evident by its use by white blood cells such as phagosomes as a mechanism for killing engulfed microbes. Staphylococcus aureus contains copper related genes, such as copA, which allow it to tolerance of excess copper, are virulence mechanisms.

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