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Literature review on cervical cancer
Literature review of knowledge regarding cervical cancer
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Cervical cancer is the second foremost occurring cancer in women after breast cancer. Cervical cancer is a sexually transmitted disease caused by the human papillomavirus, or HPV. Infection by HPV typically occurs in the early years of sexual activity according to the World Health Organization (WHO), but it can take up to a full twenty years for it to develop into a full-blown malignant tumor. Scientists believe that for all intents and purposes all cervical cancer cases are caused by infection with a few types of cancer.
Great strides have been made in recent years in the development of a vaccine to treat the cervical cancer. Scientists have cultivated a prophylactic vaccine that would protect against the human papillomavirus. HPV’s role in generating cervical cancer was discovered in 1983. The WHO’s International Agency for Research on Cancer (IARC), located in Lyon, France, has been in the forefront in epidemiological and laboratory studies needed to comprehend the disease. The IARC have chosen different methods, but the origins of most of them are based on genetically engineered Virus Like Particles (VLPs), composed of the outer structural proteins of HPV. These VLPs are not infectious or carcinogenic because they contain no DNA. Some factions are trying to produce the prophylactic vaccine alluded to earlier, while others are developing a therapeutic vaccine for individuals who are already infected. Still others are merging the two techniques. All of approaches have been presented with huge obstacles. Human papillomavirus cannot be replicated in cell culture, nor can it be transmitted to other animals, and human experimentation is limited given the carcinogenic nature of carcinogenic HPV’s that are entirely infectious. All attendees that participated at the WHO conference agreed that because of the diverse dynamic that are potentially at risk of cervical cancer that it is crucial that a prophylactic vaccine be made to targeted at a younger population that has yet to become sexually active.
The WHO also found it important that any vaccine would have to include representative people to guarantee international importance. According to researcher Luisa Lina Villa of the Ludwig Institute for Cancer Research, Sao Paulo, a potential vaccine would decrease the number of cases in developing countries . There is large discrepancy between developed countrie...
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...cancer is 78% in England and Wales 1991-95 (Cancer Survival, National Statistics)
Ø 5-year survival rate for women aged 60-69 with cervical cancer is 54% in England and Wales 1991-95 (Cancer Survival, National Statistics)
Ø 1-year survival rate for women aged 70-79 with cervical cancer is 65% in England and Wales 1991-95 (Cancer Survival, National Statistics)
Ø 5-year survival rate for women aged 70-79 with cervical cancer is 37% in England and Wales 1991-95 (Cancer Survival, National Statistics)
Ø 1-year survival rate for women aged 80-99 with cervical cancer is 49% in England and Wales 1991-95 (Cancer Survival, National Statistics)
Ø 5-year survival rate for women aged 80-99 with cervical cancer is 25% in England and Wales 1991-95 (Cancer Survival, National Statistics
In conclusion, cervical cancer, while a formidable opponent to anybody unfortunate enough to be battling it, can be prevented through both screenings and education to the demographic it affects the most: young women. With science making more and more advances every year in the field of oncology, it can be treated with a variety of procedures, both surgical and non-surgical.
The article’s information is presented with the goal of informing a reader on vaccines. The evidence is statistical and unbiased, showing data on both side effects and disease prevention, providing rates of death and serious illness from both sides. This evidence is sourced from a variety of medical organizations and seems reliable, logical, and easily understood, no language that would inspire an emotional response is used. The validity of studies is not mentioned in the article, but it does encourage readers to investigate further to help make a decision. The article allows a reader to analyze the presented evidence and come to their own
What is the human papillomavirus (HPV)? According to the US government’s National Cancer Institute, human papillomaviruses (HPVs) are a collection of more than one hundred viruses, many types having the ability to grow tumors or polyps that are malignant and others benign. Certain of the viruses are capable of forming genital warts. The HPVs that cause the common warts on hands and feet are different from those that cause growth in the throat or genital area (Human Papillomavirus). Professors Joe Cummins and Dr. Mae-Wan Ho inform us that some types are associated with cancer, and are called “high risk” HPVs. Of the more than one hundred types of HPVs, over thirty can be passed on through sexual contact. Most HPV infections occur without any symptoms and go away without treatment over the course of a few years. However, HPV infection sometimes persists for many years, with or without causing detectable cell abnormalities. Infection from “High risk” types of HPV is the main cause of cervical cancer. Pap smears have also led to earlier detection of these infections. Nearly all women who are sexually active will have HPV inf...
Most people know what vaccines are and have received them during our childhood years; but past that knowledge, most people do not think much about vaccines until we have children of our own. Some parents are more skeptical than others on the topic of vaccinations, but most parents choose this preventative measure in protecting their children from harmful diseases. However, in the case of the Human Papillomavirus (HPV) vaccine, there is quite a controversy as to if it is appropriate to administer the vaccine to pre-teen to teenage children. Genital human papillomavirus (HPV) is the most common sexually-transmitted infection in the United States; an estimated 14 million persons are newly infected every year (Satterwhite,
There are over 100 types of HPV (Human Papilloma Virus). This virus affects the skin and moist membranes that line the body such as the mouth, throat, fingers, nails, cervix, and anus. Between 30 and 40 of the 100 viruses can affect the genital area; for the most part it causes genital warts. Human Papilloma Virus is one of the most common sexually transmitted diseases In the United States, according to various studies it is estimated that at least 50% of sexually active people will get some type of genital Hpv at some time in their lives. People can get Hpv and have the virus for years, even pass it on to their sex partners without even knowing it that is because the virus often does not show any symptoms. It is a sexually transmitted disease that can cause genital warts and cervical cancer”. (“HPV fact sheet” 2012).
Peripheral blood samples were collected from 150 individuals for use in this study. 77 of the 150 samples were collected from individuals with histologically confirmed cervical carcinoma. 25 of the 77 samples were collected from individuals with stage I cervical carcinoma. 23 of the 77 samples were collected from individuals with stage II cervical carcinoma. 18 of the 77 samples were collected from individuals with stage III cervical carcinoma. 11 of the 77 samples were collected from individuals with stage IV cervical carcinoma. 73 of the 150 samples were collected from healthy individuals with no cervical carcinoma. Ten cervical carcinoma sera samples and eight normal sera samples were used to biopan; the remaining 67 cervical carcinoma samples and 65 normal samples were used to evaluate predictive value by receiver operating characteristics (ROC) curves. Total RNA was extracted from the sample cells using the acid guanidinium thiocyanate-phenol-chloroform method using Trizol as the reagent. Random hexamers were used in cDNA synthesis. BMI-1 was amplified by polymerase chain reactions (PCR). The PCR products were analyzed using agarose gel electrophoresis to confirm appropriate size and sequencing. Cells were washed and
...Although these were initially set to prevent infectious diseases it has been found that there is also prevention of autoimmune diseases, birth control and also cancer therapy. While vaccines provide a proficient means of preventing diseases and improving public health it doesn’t mean all are essential to a healthy life, some do more damage if a sufficient immune system is not present. How the vaccine is formulated and distributed is important to study and follow up on to be certain it is in the best interest of your body to receive the vaccine. Vaccinations will remain present, but it is our choice as individuals to know what they are composed of and how they are administered. Immunizations should be valued and taken seriously, this advancement in technology came at a high speed, which means flaws, and errors will exist, whether we notice them now or in the future.
The Human Papillomavirus (HPV) is the most common sexually transmitted disease in the United States (Cook 210). There are over 100 types of HPV viruses and 30 or more of these viruses that can be sexually transmitted. (Vamos, McDermott, Daley 303). There are approximately 20 million people in the United States that are infected with HPV, and there are about 6.2 million new HPV cases each year (Vamos, McDermott, and Daley 303). Even though most HPV cases are non-cancerous, two of the HPV strains are known to cause 70 percent of cervical cancer, and the other two strains cause 90 percent of genital warts cases (Javitt, Berkowitz, and Gostin 384). Mendenhall, Elisa, and O'Mara stated, "Because of the cancer link, the strains that are the greatest medical concerns are those that are sexually transmitted"(49). It is estimated that it costs the United States about five billion dollars each year to diagnose and treat HPV related diseases (Cook 211).
Cervical cancer is formed in the tissues of the cervix, an organ that connects the uterus and the vagina. Virtually all cervical cancers are caused by Human papillomavirus (HPV) infections (Schiffman et. al., 2007). HPV is the most common sexually transmitted infection in the United States. According to the CDC, 75% of sexually active people aged 15-49 have the infection at some point in their lives. (CDC). Because HPV infection is usually asymptomatic, infected people do not know exactly when they get the infection. In most cases, the body is able to fight off the virus before any symptom. However, health problems such as genital warts and cancer may result with persistent exposure to HPV.
Fewer than ten percent of most cancers are thought to be due to strong hereditary factors. Many physicians believe that prevention is the best way to effectively tackle cancer. One of those factors in prevention is the individual knowing their family history so that they can develop an awareness of their families' cancer lineage. Other factors are a balanced diet, not smoking, moderate alcohol consumption and exercise. Strong hereditary factors that increase cancer risk are more likely to be found in families that have:
Vaccinations have significantly reduced the disease rate throughout the world. Usually, vaccines prove to be between 90 and 99 percent effective. This reduces disease and mortality rate by thousands every year (Jolley and Douglas 1). On average, vaccines save the lives of 33,000 innocent children every year (“Vaccines” 1). In addition, if a vaccinated child did contract the vaccine’s targeted illness, that child would, in general, have more mild symptoms than an unvaccinated child that contracts the same illness. These vaccinated children will have less serious complications if they do contract the disease; they will be much more treatable, and have a lower risk of death (Jolley and Douglas 2). The risks of not vaccinating greatly outweigh the small risks of vaccination. Diseases like measles and mumps can cause permanent disability. While there i...
Almost 263,020 oral cavity cancers, and 127,654 oral cancer deaths occur worldwide each year1. On January 1, 2010, in the US there were approximately 275,193 women and men alive who had a history of cancer of the oral cavity and pharynx (181,084 men and 94,109 women)2. The 5-year survival rate of patients with oral cancer remains almost unchanged despite various treatment improvements in the last three decades3. Individuals at high risk of developing oral cancer (OC) are mainly older, males, heavy users of alcohol and tobacco, and have a poor diet and low socioeconomic status4, 5. Recent studies have implicated HPV infection as an independent risk factor for oro-pharyngeal cancers6, 7. For oral squamous cell carcinoma (OSCC), the role of HPV remains controversial8.
Uterine cancer is an important women health problem developing rapidly, killing over 200,000 women each year. No one has discovered the actual cause, but there is a leading factor that has great suspicions to what is causing this cancer to grow rapidly.
The CDC works closely with public health agencies and private partners in order to improve and sustain immunization coverage and to monitor the safety of vaccines so that public ...
As for the developed countries, they can collect samples from the patients so that the drug companies can produce new vaccines for new diseases. When trying to cure diseases, developed countries and poor countries would have mutual benefits by cooperating.... ... middle of paper ... ...